Abstract：
:Allergen immunotherapy leads to tolerance through multiple mechanisms that include tolerogenic dendritic cells and T and B regulatory cells. These induced cellular populations produce mediators to skew the immune response to a tolerogenic milieu that, among others, results in IgG4 blocking antibodies formation and lowered FcE receptors. All lead in decreased effector responses from mast cells, eosinophils, and basophils thus limiting the allergic inflammation. Clinically, this results in better allergic rhinitis control and, of importance, asthma prevention. Newer approaches include modified allergens, second generation adjuvants/carriers and routes of administration, all aiming to increased efficacy with parallel no compromise of safety.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Mitsias DI,Xepapadaki P,Makris M,Papadopoulos NGdoi
10.1016/j.coi.2020.02.005subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1-8eissn
0952-7915issn
1879-0372pii
S0952-7915(20)30021-2journal_volume
66pub_type
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journal_title：Current opinion in immunology
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