Abstract：
:Antibody deficiencies are the most prevalent forms of primary immunodeficiencies (PIDs). Several disease-causing mutations have been identified to date, but still, the genetic background of most patients remains elusive. During the last 2 years, next generation sequencing has revealed the genetic basis for a number of these disorders. Having as a reference the latest International Union of Immunological Societies classification on PIDs, we present 9 novel genetic defects/mechanisms that are associated with antibody deficiency, affecting either early or late B-cell development. The role of dysregulated autophagy in antibody deficiency is highlighted. The latest advance in this field provides new insights to our understanding of the regulation of antibody production in human B cells.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Liadaki K,Sun J,Hammarström L,Pan-Hammarström Qdoi
10.1016/j.coi.2013.06.003subject
Has Abstractpub_date
2013-10-01 00:00:00pages
629-38issue
5eissn
0952-7915issn
1879-0372pii
S0952-7915(13)00104-0journal_volume
25pub_type
杂志文章,评审abstract：:The Notch family of evolutionarily conserved proteins regulates a broad spectrum of cell-fate decisions and differentiation processes during fetal and post-natal development. The best characterized role of Notch signaling during mammalian hematopoiesis and lymphopoiesis is the essential function of the Notch1 receptor...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2010.12.008
更新日期：2011-04-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(91)90003-j
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(03)00002-5
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2013.10.015
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2006.06.002
更新日期：2006-10-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2004.09.002
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2007.01.002
更新日期：2007-04-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(93)90061-v
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：2018-08-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：2018-08-01 00:00:00
abstract：:Significant advances in research on the immunopathogenesis of leishmaniasis include the discovery of novel putative evasion and survival strategies of Leishmania parasites, a more detailed understanding of the function and regulation of interleukin-12, definition of molecules involved in cognate interaction between ma...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(96)80040-9
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