Abstract:
:It has recently become clear that several factors must coincide for the initiation of autoimmunity. At minimum, these involve a genetic predisposition, naive lymphocytes that can react with autoantigens and a precipitating event that leads to T and/or B cell activation. Inter-individual variations in these factors probably explain the significant complexity associated with autoimmune diseases; however, quantitative issues are also important because clinical disease will manifest only if a sufficient amount of cellular material has been destroyed. Therefore, the presence of autoreactive lymphocytes does not always signify disease; rather, the kinetics of their generation, their resulting numbers and the regulation of their activation and effector functions (destructive versus regulatory) will determine the ultimate outcome and make the difference between subclinical autoimmunity and disease.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Christen U,von Herrath MGdoi
10.1016/j.coi.2004.09.002subject
Has Abstractpub_date
2004-12-01 00:00:00pages
759-67issue
6eissn
0952-7915issn
1879-0372pii
S0952-7915(04)00146-3journal_volume
16pub_type
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