Epigenetic regulation of antigen receptor gene rearrangement.

abstract：:The intestinal mucosa is continuously exposed to harmless exogenous antigens derived from food proteins and microbiota. Continuous surveillance by suppressive regulatory T cells prevents inflammatory responses to these antigens thereby maintaining intestinal homeostasis. The nature of the antigenic pressure varies at ...

journal_title：Current opinion in immunology

authors： Veenbergen S,Samsom JN

更新日期：2012-06-01 00:00:00

abstract：:While mutations in human FOXP3 predispose individuals to autoimmune conditions, it is unclear how the mutant protein fails to function as a transcriptional regulator. There is also limited detail of how FOXP3 itself interacts with the transcriptional machinery and which components of the FOXP3 ensembles exert phenotyp...

journal_title：Current opinion in immunology

authors： Li B,Saouaf SJ,Samanta A,Shen Y,Hancock WW,Greene MI

更新日期：2007-10-01 00:00:00

abstract：:Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is respon...

journal_title：Current opinion in immunology

authors： Boss JM

更新日期：1997-02-01 00:00:00

abstract：:MHC class II molecules (MHC-II) present antigenic fragments acquired in the endocytic route to the immune system for recognition and activation of CD4+ T cells. This ignites a series of immune responses. MHC-II strongly correlates to most autoimmune diseases. Understanding the biology of MHC-II is therefore expected t...

journal_title：Current opinion in immunology

authors： van den Hoorn T,Paul P,Jongsma ML,Neefjes J

更新日期：2011-02-01 00:00:00

abstract：:Food allergy is now known to encompass a number of distinct clinical entities that follow the ingestion of specific food or food additives. Research continues to shed light on immediate reactions to foods and food protein-induced enterocolitis of newborns and infants. Adverse reactions to food additives remain an area...

journal_title：Current opinion in immunology

authors： Metcalfe DD

更新日期：1991-12-01 00:00:00

abstract：:The development of novel vaccine candidates against infections with Mycobacterium tuberculosis has highlighted our limited understanding of immune mechanisms required to kill M. tuberculosis. The induction of a Th1 immunity is vital, but new studies are required to identify other mechanisms that may be necessary. Nove...

journal_title：Current opinion in immunology

authors： Izzo AA

更新日期：2017-08-01 00:00:00

abstract：:We are in a 'golden age' of mouse genetics. Genetic engineering and micromanipulation techniques now allow not only the overexpression or misexpression of transgenes randomly inserted into the mouse genome, but also the directed homologous replacement of normal genes with transgenes coding for null or mutant alleles (...

journal_title：Current opinion in immunology

authors： Seldin DC

更新日期：1995-10-01 00:00:00

abstract：:Significant insight has been gained into constraints on the sensitivity and specificity of staining with class I tetramers. The function of the populations that are defined varies with the clinical situation. Insight has also been gained into the determinants of the CD8(+) T cell response during primary and chronic HI...

journal_title：Current opinion in immunology

authors： Kelleher AD,Rowland-Jones SL

更新日期：2000-08-01 00:00:00

abstract：:Initially, direct oncolysis was thought to be the sole mechanism through which oncolytic viruses (OVs) exert their anti-tumor effect, and the immune system was perceived as the major obstacle in oncolytic virotherapy. Over the last decade, there has been a lot of debate on whether the immune system is a friend or foe ...

journal_title：Current opinion in immunology

authors： Chaurasiya S,Chen NG,Fong Y

更新日期：2018-04-01 00:00:00

abstract：:Murine gamma-herpesvirus 68 (gammaHV68) infection is a new model for understanding how immunity and chronic gamma-herpesvirus infection inter-relate. gammaHV68 is closely related to the human Epstein-Barr virus and Kaposi's sarcoma herpesvirus and is associated with tumors, vasculitis of the great elastic arteries and...

journal_title：Current opinion in immunology

authors： Virgin HW,Speck SH

更新日期：1999-08-01 00:00:00

abstract：:Many humanized antibodies and fusion proteins targeting T-cell co-stimulatory molecules are now in late-stage clinical development (phase II, phase III) or have recently completed phase III clinical trials. Both Amevive, an LFA-3-Ig fusion protein targeting CD2, and Xanelim, a humanized anti-CD11a antibody, have shown...

journal_title：Current opinion in immunology

authors： Aruffo A,Hollenbaugh D

更新日期：2001-12-01 00:00:00

abstract：:Analysis of the T-cell receptor has revealed the molecular basis of antigen recognition by T cells specific for viral antigens. Studies using T-cell receptor transgenic mice have provided evidence for clonal deletion of virus-specific T cells in persistently infected hosts and for selection of T-cell-resistant virus v...

journal_title：Current opinion in immunology

authors： Yanagi Y

更新日期：1991-08-01 00:00:00

abstract：:Recent research has made great strides in uncovering the mechanisms by which the T helper 1 (Th1) cell gene expression program is established. In particular, studies examining the transcription factors T-bet, STAT1, and STAT4 have elucidated their roles in regulating Th1 signature genes, including Ifng, and have start...

journal_title：Current opinion in immunology

authors： Oestreich KJ,Weinmann AS

更新日期：2012-04-01 00:00:00

abstract：:Although autoantigen-induced negative selection plays an important role in shaping the mature B-cell repertoire, studies in recent years have suggested that differentiation into any of the three mature B-cell subsets (marginal zone B cells, follicular B cells and B-1 B cells) is not a passive product of autoreactive B...

journal_title：Current opinion in immunology

authors： Wang H,Clarke SH

更新日期：2004-04-01 00:00:00

abstract：:T cells are spared from programmed cell death in the thymus after an appropriate interaction between the T-cell receptor and a self peptide/MHC complex; this step is referred to as positive selection. Recent work has focused on precise identification of the positively selecting ligand, and the cell that presents it. F...

journal_title：Current opinion in immunology

authors： Hogquist KA,Jameson SC,Bevan MJ

更新日期：1994-04-01 00:00:00

abstract：:The field of Type 1 diabetes research has been quick to embrace the era of translational medicine in the recent epoch. Building upon some 30 years of intense immunological research, the past decade has been marked by a series of clinical trials designed to evaluate the potential beneficial effects of a range of immune...

journal_title：Current opinion in immunology

authors： Roep BO,Peakman M

更新日期：2011-12-01 00:00:00

abstract：:Thymocytes co-expressing the CD4 and CD8 co-receptors differentiate into mature T cells that express either CD4 or CD8 and have helper or cytotoxic functions, respectively. Recent studies indicate that commitment to the CD4+ or CD8+ lineages occurs stochastically, but retention of the appropriate co-receptor is requir...

journal_title：Current opinion in immunology

authors： Davis CB,Littman DR

更新日期：1994-04-01 00:00:00

abstract：:Intimate interactions between multipotential hemopoietic stem cells and their microenvironment work towards redefining the identity and the differentiative fate of these primitive cells. Molecular cues delivered by the microenvironment frequently act in an instructive fashion by initiating intracellular signaling path...

journal_title：Current opinion in immunology

authors： Georgopoulos K

更新日期：1997-04-01 00:00:00

abstract：:Tumor vaccinology is as old as immunological thought and as young as our rapidly evolving understanding of antigen processing and presentation. The recent availability of carbohydrate and peptide tumor antigens suitable for vaccine construction, conjugate and recombinant vector technologies capable of augmenting helpe...

journal_title：Current opinion in immunology

authors： Livingston PO

更新日期：1992-10-01 00:00:00

abstract：:The hygiene hypothesis was initially formulated to explain the steep increase in the prevalence of allergies in Western societies observed over the past few decades. It proposes that the microbial environment interfaces with the innate immune system and modulates its ability to impart instructions to adaptive immune r...

journal_title：Current opinion in immunology

authors： Vercelli D

更新日期：2006-12-01 00:00:00

abstract：:The development and maintenance of regulatory T (T-reg) cells is crucial for determining the level of reactivity in the immune system. Until recently, however, surprisingly little was known about the factors involved in the development of these cells in the thymus or the mechanisms that maintain them in the periphery....

journal_title：Current opinion in immunology

authors： Liston A,Rudensky AY

更新日期：2007-04-01 00:00:00

abstract：:Recent evidence indicates that genes required for antigen processing are present in the class II region of the MHC. Two new classes of MHC genes that may encode much of the machinery required in the class I (endogenous) antigen-processing pathway have been discovered. There is evidence that genes required in the class...

journal_title：Current opinion in immunology

authors： Monaco JJ

更新日期：1992-02-01 00:00:00

abstract：:Many recent studies suggest an involvement of gamma delta T cells in the immune response to infectious pathogens including viruses, bacteria and eukaryotic parasites. However, it remains unclear whether the responses of gamma delta T cells are specifically directed against antigens derived from these pathogens or agai...

journal_title：Current opinion in immunology

authors： Born WK,Harshan K,Modlin RL,O'Brien RL

更新日期：1991-08-01 00:00:00

abstract：:Innate immunity, our inborn immediate defence mechanism, was thought for a long time to be non-specific and, consequently, research into innate mechanisms often took second place to research into adaptive immunity. In recent decades, however, the spotlight has shone on groundbreaking advances into mechanisms of innate...

journal_title：Current opinion in immunology

authors： Coutinho A,Poltorack A

更新日期：2003-12-01 00:00:00

abstract：:The development of genetic epidemiology methods using recent human genetic mapping information, together with the growing availability of candidate genes, has led to major advances in the identification of host genes involved in human infectious diseases. Within the past year, highlights include the mapping of a locus...

journal_title：Current opinion in immunology

authors： Abel L,Dessein AJ

更新日期：1997-08-01 00:00:00

abstract：:Various new aspects of antigen processing have been uncovered through the study of tumor antigens. One of these is the production of antigenic peptides by splicing of two distinct peptide fragments. In one of the two cases reported, the proteasome was found to be responsible for splicing. The presentation of another p...

journal_title：Current opinion in immunology

authors： van der Bruggen P,Van den Eynde BJ

更新日期：2006-02-01 00:00:00

abstract：:Neurodegenerative diseases, such as Parkinson's and Alzheimer's, affect millions of people and pose major personal and socioeconomic burdens. The causes of neurodegeneration are mostly unknown, although current efforts have described an autoimmune aspect to these diseases. Here we discuss recent findings that shed lig...

journal_title：Current opinion in immunology

authors： Lindestam Arlehamn CS,Garretti F,Sulzer D,Sette A

更新日期：2019-08-01 00:00:00

abstract：:Invariant natural killer T cells (iNKT cells) express a restricted T cell antigen receptor (TCR) repertoire and they respond rapidly to glycolipid antigens presented by CD1d. These glycolipid antigens have hexose sugars in alpha-linkage to two types of lipids that can bind to CD1d. Recent work has shown that the respo...

journal_title：Current opinion in immunology

authors： Kronenberg M,Kinjo Y

更新日期：2009-08-01 00:00:00

abstract：:The germinal center (GC) is an important anatomical site for the development of high affinity antibodies during T-cell dependent B cell responses. Although the importance of the GC response to humoral immunity is well known, much remains to be elucidated about GC induction, maintenance and regulation. Recent studies e...

journal_title：Current opinion in immunology

authors： Cozine CL,Wolniak KL,Waldschmidt TJ

更新日期：2005-06-01 00:00:00

abstract：:The invariant chain (Ii) has been shown to play a critical role in the assembly, intracellular transport and function of MHC class II molecules. Recent studies suggest that these distinct activities can in many cases be attributed to distinct isoforms of Ii or to specific regions within it. Thus, regulation of Ii synt...

journal_title：Current opinion in immunology

authors： Sant AJ,Miller J

更新日期：1994-02-01 00:00:00