Abstract:
:Engagement of the TCR/CD3 complex triggers a cascade of events that result in T lymphocyte activation and promote positive and negative selection of thymocytes, T lymphocyte migration and effector functions, development and activation of regulatory T cells. Gene mutations that abrogate early TCR signaling are associated with profound abnormalities of T lymphocyte development and function both in humans and in mice, causing susceptibility to severe infections since early in life. In recent years, a growing number of genetic defects have been discovered that reduce, but do not completely abrogate proximal TCR signaling. These defects result in complex phenotypic manifestations that are not limited to immunodeficiency, but also include immune dysregulation. The identification of these conditions may also prompt development of novel therapeutic strategies for autoimmune disorders.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Notarangelo LDdoi
10.1016/j.coi.2014.10.003subject
Has Abstractpub_date
2014-12-01 00:00:00pages
97-101eissn
0952-7915issn
1879-0372pii
S0952-7915(14)00127-7journal_volume
31pub_type
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
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abstract::Enteric microbial pathogens interact with the gut epithelium to establish infection. Recently, it has become clear that many microorganisms that colonize or traverse the intestinal mucosa do so via the specialized M cells. Recent work has shown that Shigella flexneri and Salmonella typhimurium specifically target M ce...
journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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abstract::The challenge for any vaccine design is to elicit protective humoral and/or cytotoxic immunity against life threatening pathogens while remaining innocuous. Neonatal vaccinology faces additional challenges linked to intrinsic peculiarities of the innate and adaptive neonatal immune system. These include anti-inflammat...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
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abstract::Recent findings indicate that activated T lymphocytes, showing restricted T-cell receptor repertoire and a Th1-like profile of cytokine production, are responsible for macrophage activation and release of inflammatory cytokines, toxic oxygen metabolites and nitric oxide, which initiate and maintain the transmural inte...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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abstract::Although autoantigen-induced negative selection plays an important role in shaping the mature B-cell repertoire, studies in recent years have suggested that differentiation into any of the three mature B-cell subsets (marginal zone B cells, follicular B cells and B-1 B cells) is not a passive product of autoreactive B...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2004.01.006
更新日期:2004-04-01 00:00:00
abstract::The extraordinary sensitivity and specificity of T cells for their cognate antigen make them a highly attractive cancer therapeutic. However, the rarity of tumor-reactive T cells in cancer patients, the difficulty isolating them in sufficient numbers for adoptive immunotherapy, and the unpredictable persistence of tra...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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abstract::Peptides presented by MHC class I molecules are typically produced through antigen degradation by the proteasome followed by trimming by exopeptidases. According to recent results, these include both aminopeptidases and carboxypeptidases in the cytosol and the endoplasmic reticulum. While cytosolic peptidases have a n...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
abstract::During the past couple of years there has been significant progress in our understanding of the development of different lineages of T cells within the thymus. Pathways, subpopulations and cellular dynamics are all becoming clearer. Signal transduction through primary and accessory receptors is also beginning to be un...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:1991-04-01 00:00:00
abstract::Invariant natural killer T cells (iNKT cells) express a restricted T cell antigen receptor (TCR) repertoire and they respond rapidly to glycolipid antigens presented by CD1d. These glycolipid antigens have hexose sugars in alpha-linkage to two types of lipids that can bind to CD1d. Recent work has shown that the respo...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2009.07.002
更新日期:2009-08-01 00:00:00