Abstract:
:The intestinal mucosa is continuously exposed to harmless exogenous antigens derived from food proteins and microbiota. Continuous surveillance by suppressive regulatory T cells prevents inflammatory responses to these antigens thereby maintaining intestinal homeostasis. The nature of the antigenic pressure varies at different locations of the intestinal tract. In agreement with this strong microenvironmental control, small intestinal and colonic regulatory T cell homeostasis varies considerably. In this review, we summarize the substantial advances that have been made in dissecting the phenotype and function of intestinal regulatory T cells, discuss how microbiota can modulate the intestinal regulatory T cell pool and review the crucial role of the immunoregulatory cytokine interleukin-10 (IL-10) in shaping and maintenance of mucosal tolerance.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Veenbergen S,Samsom JNdoi
10.1016/j.coi.2012.03.004subject
Has Abstractpub_date
2012-06-01 00:00:00pages
269-76issue
3eissn
0952-7915issn
1879-0372pii
S0952-7915(12)00048-9journal_volume
24pub_type
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:2014-02-01 00:00:00
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journal_title:Current opinion in immunology
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pub_type: 杂志文章,评审
doi:10.1016/0952-7915(93)90112-6
更新日期:1993-12-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2004.03.014
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(98)80162-3
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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abstract::Antimicrobials represent a broad class of chemicals with the intended purpose of eliminating or controlling the growth of harmful microorganisms. Exposure can occur occupationally or through the use or consumption of consumer products. The use of antimicrobial agents has been associated with an increased incidence of ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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