Abstract:
:Peptides presented by MHC class I molecules are typically produced through antigen degradation by the proteasome followed by trimming by exopeptidases. According to recent results, these include both aminopeptidases and carboxypeptidases in the cytosol and the endoplasmic reticulum. While cytosolic peptidases have a net neutral or destructive effect on MHC ligands, endoplasmic reticulum aminopeptidases are required for efficient class I loading and have a strong effect on the repertoire of peptide/MHC complexes. Cells lacking these enzymes can be eliminated both by NK cells and by CD8+ T cells recognizing complexes formed between an MHC class Ib molecule and a conserved peptide. Cross-presented peptides derived from internalized antigens can be processed by insulin-regulated aminopeptidase, the only endosomal trimming peptidase.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Weimershaus M,Evnouchidou I,Saveanu L,van Endert Pdoi
10.1016/j.coi.2012.10.001subject
Has Abstractpub_date
2013-02-01 00:00:00pages
90-6issue
1eissn
0952-7915issn
1879-0372pii
S0952-7915(12)00156-2journal_volume
25pub_type
杂志文章,评审abstract::Suppressor T cells down-regulate the activity of other cells in the immune system, and, albeit controversial, are believed to play a role in immunological tolerance and immunoregulation. Significant progress has been made in characterizing suppressor T cells and their receptors, and in elucidating mechanisms of immuno...
journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2004.09.002
更新日期:2004-12-01 00:00:00
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:1995-06-01 00:00:00
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2018.05.014
更新日期:2018-10-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2013.10.015
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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abstract::Immune system function declines with age. Here we review and compare age-associated changes in murine and human B cell pools and humoral immune responses. We summarize changes in B cell generation and homeostasis, as well as notable changes at the subcellular level; then discuss how these changes help to explain alter...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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