Abstract:
:The innate immune system is comprised of a sophisticated network of recognition and effector molecules that act together to protect the host in the first minutes or hours of exposure to an infectious challenge. The mannose-binding lectin (MBL) is an evolutionary conserved circulating host defense protein that acts as a broad-spectrum recognition molecule against a wide variety of infectious agents. Target binding triggers the MBL pathway of complement activation. MBL can be considered conceptually as an 'ante-antibody' because it has a role in mammals during the lag period that is required to develop an antibody response against infectious agents. Additionally, there are MBL-like homologues in animals that lack adaptive immunity that activate a primitive complement system, and under these circumstances these MBL-like molecules play an analogous role to antibodies in higher animals. These molecules might be considered to be functional antecedents of antibodies. Recent work also indicates that MBL recognizes altered self-antigens, and as such MBL has a role that extends beyond a traditional role in first line host defense as it appears to play a role as a modulator of inflammation.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Takahashi K,Ip WE,Michelow IC,Ezekowitz RAdoi
10.1016/j.coi.2005.11.014subject
Has Abstractpub_date
2006-02-01 00:00:00pages
16-23issue
1eissn
0952-7915issn
1879-0372pii
S0952-7915(05)00207-4journal_volume
18pub_type
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