Abstract：
:The rise in IgE-mediated food allergy in recent times is the likely result of gene-environment interactions mediated via epigenetic pathways. As epigenetic modifications, including DNA methylation, are at the interface between the environment and the genome, they may be ideal biomarkers of modifiable disease pathways. High-throughput methylation profiling of immune cell subtypes or whole blood from patients allows the identification of disease specific epigenetic variants. If faithfully tracking with disease parameters, these 'signatures' may have clinical applications as biomarkers of disease or therapeutic response. Development of such tools will depend on a number of factors, including determining the most appropriate experimental approach, analysis methodology, patient groups, and informative target cells/tissues. Here we discuss these potential applications and their implications for food allergy practise.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Martino DJ,Saffery R,Allen KJ,Prescott SLdoi
10.1016/j.coi.2016.05.005subject
Has Abstractpub_date
2016-10-01 00:00:00pages
9-15eissn
0952-7915issn
1879-0372pii
S0952-7915(16)30045-0journal_volume
42pub_type
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