Abstract:
:A little more than a decade after the explosion of research into recombinant live-attenuated or replication-deficient viruses as vaccine platforms, many viral vector-based vaccines have been licensed for animals. Progress has been slower for humans but 2011 will see the licensure of the first viral-vectored vaccine for humans, against Japanese Encephalitis. In addition a vaccine with a viral-vectored component showed efficacy against HIV infection in humans. Viral-based vaccines have an excellent safety profile but must deal with the potential problem of pre-existing anti-vector immunity. Recent successes reflect diverse improvements such as development of new adenovirus serotypes and better prime-boost approaches, suggesting that many viral vectors are approaching their final years as vaccine 'candidates' rather than vaccines.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Rollier CS,Reyes-Sandoval A,Cottingham MG,Ewer K,Hill AVdoi
10.1016/j.coi.2011.03.006subject
Has Abstractpub_date
2011-06-01 00:00:00pages
377-82issue
3eissn
0952-7915issn
1879-0372pii
S0952-7915(11)00031-8journal_volume
23pub_type
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