Abstract:
:Typical immune responses lead to the prominent clonal expansion of antigen-specific T cells followed by their differentiation into effector cells. Most effector cells die at the end of the immune response but some of the responding cells survive and form long-lived memory cells. The factors controlling the formation and survival of memory T cells are discussed. Recent evidence suggests that T memory cells arise from a subset of effector cells. The longevity of T memory cells may require continuous contact with cytokines, notably IL-15 for CD8(+) cells.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Sprent J,Surh CDdoi
10.1016/s0952-7915(00)00211-9subject
Has Abstractpub_date
2001-04-01 00:00:00pages
248-54issue
2eissn
0952-7915issn
1879-0372pii
S0952-7915(00)00211-9journal_volume
13pub_type
杂志文章,评审abstract::We are in a 'golden age' of mouse genetics. Genetic engineering and micromanipulation techniques now allow not only the overexpression or misexpression of transgenes randomly inserted into the mouse genome, but also the directed homologous replacement of normal genes with transgenes coding for null or mutant alleles (...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(95)80075-1
更新日期:1995-10-01 00:00:00
abstract::Our understanding of NKT cells has been rapidly advancing over recent years, with many research groups studying how these cells behave and how they can be manipulated to prevent disease. Although good progress has been made, a difficulty is the lack of a clear consensus about how to assay, or even identify, NKT cells....
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2005.05.012
更新日期:2005-08-01 00:00:00
abstract::The classification of T helper (T(H)) cells in subsets has progressively expanded and more effector subsets, besides T(H)1 and T(H)2, have been documented. These include follicular helper T cells (T(FH)), and the more recent T(H)17, 'T(H)9', and 'T(H)22'. In addition, T(H) are no longer thought of as terminally commit...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2009.07.009
更新日期:2009-12-01 00:00:00
abstract::Chronic non-communicable diseases (NCDs) are increasingly recognized as the major cause of morbidity and mortality worldwide. Effective, affordable and broadly accessible medicines for their treatment are much sought after. Therapeutic B-cell vaccines aim at inducing neutralizing auto-reactive antibodies against impor...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2010.02.009
更新日期:2010-06-01 00:00:00
abstract::Recent studies of the regulation of antigen receptor rearrangement have revealed several completely new levels of control. Not only do antigen receptor loci undergo changes in histone modifications as they become accessible for recombination, but also the number of different histone modifications and the variation at ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2010.12.008
更新日期:2011-04-01 00:00:00
abstract::The production of pathogenic autoantibodies in organ-specific autoimmune diseases is largely T cell dependent. For many of these diseases, the precise specificities and cytokine profiles of the T cells that respond to the corresponding autoantigens have now been identified. This knowledge has been exploited to treat s...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(00)00160-6
更新日期:2000-12-01 00:00:00
abstract::Three known lineages of antigen-presenting molecules restrict T-cell responses to microbial antigens: MHC class I and MHC encoded class I like molecules present peptides derived from the proteolysis of intracellular pathogens, MHC class ii molecules present peptides derived from the proteolysis of extracellular pathog...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:1996-02-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2019.11.001
更新日期:2020-04-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:1994-02-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2016.09.005
更新日期:2016-12-01 00:00:00
abstract::Zika virus (ZIKV) is the most recent mosquito-transmitted virus to cause a global health crisis following its entrance into a naïve population in the Western Hemisphere. Once the ZIKV outbreak began investigators rapidly established small and large animal models of pathogenesis, developed a number candidate vaccines u...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2018.04.024
更新日期:2018-08-01 00:00:00
abstract::V(D)J recombination in B and T cells is required for the generation of receptors with a broad spectrum of specificity to foreign antigen. A total number of three immunoglobulin (Ig) and four T cell receptor (Tcr) loci can be targeted by the recombinase enzyme (RAG1/2) in a defined series of recombination events, which...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2012.01.003
更新日期:2012-04-01 00:00:00
abstract::Atherosclerosis is a chronic inflammatory disease that causes most heart attacks and strokes, making it the biggest killer in the world. Although cholesterol-lowering drugs have dramatically reduced these major adverse cardiovascular events, there remains a high residual risk called inflammatory risk. Atherosclerosis ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2019.02.008
更新日期:2019-08-01 00:00:00
abstract::The hallmark of the innate immune response of higher insects is the rapid and transient synthesis of a battery of broad spectrum antimicrobial peptides by the fat body. The control of the genes encoding these peptides involves cis-regulatory promoter elements homologous to sequences functional in mammalian acute-phase...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(96)80098-7
更新日期:1996-02-01 00:00:00
abstract::Regulatory T (Treg) cells suppress effector T (Teff) cells and prevent immune-mediated rejection of cancer. Much less appreciated are mechanisms by which Teff cells antagonize Treg cells. Herein, we consider how complex reciprocal interactions between Teff and Treg cells shape their population dynamics within tumors. ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2015.02.003
更新日期:2015-04-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2020.08.003
更新日期:2020-10-07 00:00:00
abstract::The adhesive phenotypes expressed by Plasmodium-falciparum-infected erythrocytes were previously thought simply to permit sequestration of parasites in the peripheral circulation. Recent work has illuminated how falciparum-infected erythrocytes may modulate the function of monocytes, macrophages and myeloid dendritic ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(02)00368-0
更新日期:2002-08-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2014.02.003
更新日期:2014-06-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:2003-10-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(98)80218-5
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:1994-12-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2013.07.006
更新日期:2013-08-01 00:00:00
abstract::Most viral vaccines provide protection from infection through the generation of neutralizing antibodies (nAbs). The repertoire of B cells responding to immunization is the starting material from which nAbs eventually arise. Immunization strategies are increasingly targeting precise B cell specificities to mimic nAbs g...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2018.08.002
更新日期:2018-08-01 00:00:00
abstract::The adoptive transfer of donor-type CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) protects from graft-versus-host disease in murine bone marrow transplantation models. Results from first clinical trials exploring such strategies have recently been presented and seem to confirm the efficacy of Treg for the prevention...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2011.06.006
更新日期:2011-10-01 00:00:00
abstract::Immunological memory can be regulated during either its development or its maintenance phases. Controversy and confusion surround both methods of regulation, especially in the field of T-cell memory. Recent work has helped in improving our definition of 'a memory cell', but this has been complicated by another major p...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:1994-06-01 00:00:00
abstract::Innate and adaptive immune responses target pathogenic fungi and provide defense against fungal infections. Recent studies demonstrate that specific host receptors recognize ligands that are unique to fungi and activate signaling cascades that lead to phagocytosis of fungi, generation of pro-inflammatory mediators, fo...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2006.05.003
更新日期:2006-08-01 00:00:00
abstract::Tumor vaccinology is as old as immunological thought and as young as our rapidly evolving understanding of antigen processing and presentation. The recent availability of carbohydrate and peptide tumor antigens suitable for vaccine construction, conjugate and recombinant vector technologies capable of augmenting helpe...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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abstract::Cancer results from a tumor cell intrinsic dysregulation of oncogenes, tumor suppressor and stability genes as well as from the avoidance of immunosurveillance. A complex network of cellular interactions allows one to mount cognate anti-tumor immune responses. Recently, discoveries have been made regarding the links b...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2007.02.003
更新日期:2007-04-01 00:00:00
abstract::Macrophages have specialized functions in different tissue microenvironments such as lymphohaemopoietic organs and the nervous system. Recently, progress has been made in defining cellular and molecular properties of isolated and tissue macrophages in the developing and adult animal. ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(92)90119-y
更新日期:1992-02-01 00:00:00
abstract::Gene expression variation is critical for the normal development and physiology of immune cells. Using cDNA microarrays, a systematic, genomic-scale view of gene expression in immune cells at many stages of differentiation and activation can be obtained. From the high vantagepoint provided by this technology, the gene...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(99)00078-3
更新日期:2000-04-01 00:00:00