Helper T cells in antibody-mediated, organ-specific autoimmunity.

abstract：:The concept of induction immunosuppression is evolving. Once used to buttress the inadequacies of past maintenance immunosuppressive regimens, it is now being used to permit effective maintenance immunosuppression using ever decreasing amounts of modern agents. In addition to lymphocyte depletion, with which it was on...

journal_title：Current opinion in immunology

authors： Hale DA

更新日期：2004-10-01 00:00:00

abstract：:Thymocytes co-expressing the CD4 and CD8 co-receptors differentiate into mature T cells that express either CD4 or CD8 and have helper or cytotoxic functions, respectively. Recent studies indicate that commitment to the CD4+ or CD8+ lineages occurs stochastically, but retention of the appropriate co-receptor is requir...

journal_title：Current opinion in immunology

authors： Davis CB,Littman DR

更新日期：1994-04-01 00:00:00

abstract：:Enteric microbial pathogens interact with the gut epithelium to establish infection. Recently, it has become clear that many microorganisms that colonize or traverse the intestinal mucosa do so via the specialized M cells. Recent work has shown that Shigella flexneri and Salmonella typhimurium specifically target M ce...

journal_title：Current opinion in immunology

authors： Jones B,Pascopella L,Falkow S

更新日期：1995-08-01 00:00:00

abstract：:Engagement of the TCR/CD3 complex triggers a cascade of events that result in T lymphocyte activation and promote positive and negative selection of thymocytes, T lymphocyte migration and effector functions, development and activation of regulatory T cells. Gene mutations that abrogate early TCR signaling are associat...

journal_title：Current opinion in immunology

authors： Notarangelo LD

更新日期：2014-12-01 00:00:00

abstract：:Somatic mutations in the genome represent one of the major drivers of malignancy. However, non-synonymous mutations are also a source of mutated peptides that are presented by HLA molecules to induce protective CD4 and CD8 T cell responses. Consistent with this notion, the mutation burden of a tumor is correlated with...

journal_title：Current opinion in immunology

authors： Schumacher TN,Hacohen N

更新日期：2016-08-01 00:00:00

abstract：:Human papillomaviruses (HPVs) have been associated with benign and malignant epithelial proliferations in either skin or mucosa. Two HPV oncogenic proteins, E6 and E7, are important in the induction and maintenance of cellular transformation and are co-expressed in the majority of HPV-containing carcinomas. Therefore,...

journal_title：Current opinion in immunology

authors： Wu TC

更新日期：1994-10-01 00:00:00

abstract：:While the role of PD-1 in inhibiting immunity during chronic infections is well established, its functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T cell responses during some acute infections and restrain responses by 'helpless' CD8 memory T cells. An emerging role for PD-1 in inn...

journal_title：Current opinion in immunology

authors： Brown KE,Freeman GJ,Wherry EJ,Sharpe AH

更新日期：2010-06-01 00:00:00

abstract：:Systems biology strives to derive accurate predictive descriptions of complex systems such as innate immunity. The innate immune system is essential for host defense, yet the resulting inflammatory response must be tightly regulated. Current understanding indicates that this system is controlled by complex regulatory ...

journal_title：Current opinion in immunology

authors： Smith KD,Bolouri H

更新日期：2005-02-01 00:00:00

abstract：:Tumor vaccinology is as old as immunological thought and as young as our rapidly evolving understanding of antigen processing and presentation. The recent availability of carbohydrate and peptide tumor antigens suitable for vaccine construction, conjugate and recombinant vector technologies capable of augmenting helpe...

journal_title：Current opinion in immunology

authors： Livingston PO

更新日期：1992-10-01 00:00:00

abstract：:Many of the pathogens that cause human infectious diseases do not infect rodents or other mammalian species. Small animal models that allow studies of the pathogenesis of these agents and evaluation of drug efficacy are critical for identifying ways to prevent and treat human infectious diseases. Immunodeficient mice ...

journal_title：Current opinion in immunology

authors： Brehm MA,Jouvet N,Greiner DL,Shultz LD

更新日期：2013-08-01 00:00:00

abstract：:A two chain model, composed of ligand-binding and signal transducing subunits, first identified in the interleukin-6 receptor system, has been revealed in several other cytokine systems. Common signal transducers shared by several receptor systems may explain a functional redundancy characteristic of cytokines. The si...

journal_title：Current opinion in immunology

authors： Akira S,Kishimoto T

更新日期：1992-06-01 00:00:00

abstract：:Mucosal vaccines may be used both to prevent mucosal infections through the activation of antimicrobial immunity and to treat systemic inflammatory diseases through the induction of antigen-specific mucosal tolerance. New, efficient mucosal adjuvants for human use have been designed based on, amongst others, bacterial...

journal_title：Current opinion in immunology

authors： Eriksson K,Holmgren J

更新日期：2002-10-01 00:00:00

abstract：:The steep rise in the incidence and prevalence of food allergy (FA) in the last few decades have focused attention of environmental mechanisms which act to promote disease, chief among which is the microbiome. Recent studies have now established the presence of pathogenic dysbiosis in FA that could be precipitated by ...

journal_title：Current opinion in immunology

authors： Stephen-Victor E,Chatila TA

更新日期：2019-10-01 00:00:00

abstract：:The treatment of autoimmune diseases using conventional chemical immunosuppressants has short-term effects, imposing the need for chronic treatment with its risks of over-immunosuppression. CD3-specific monoclonal antibodies can restore self-tolerance in a durable fashion after a single short-term treatment, as demons...

journal_title：Current opinion in immunology

authors： Chatenoud L

更新日期：2005-12-01 00:00:00

abstract：:Allergen immunotherapy leads to tolerance through multiple mechanisms that include tolerogenic dendritic cells and T and B regulatory cells. These induced cellular populations produce mediators to skew the immune response to a tolerogenic milieu that, among others, results in IgG4 blocking antibodies formation and low...

journal_title：Current opinion in immunology

authors： Mitsias DI,Xepapadaki P,Makris M,Papadopoulos NG

更新日期：2020-10-01 00:00:00

abstract：:The development of genetic epidemiology methods using recent human genetic mapping information, together with the growing availability of candidate genes, has led to major advances in the identification of host genes involved in human infectious diseases. Within the past year, highlights include the mapping of a locus...

journal_title：Current opinion in immunology

authors： Abel L,Dessein AJ

更新日期：1997-08-01 00:00:00

abstract：:Analysis of the T-cell receptor has revealed the molecular basis of antigen recognition by T cells specific for viral antigens. Studies using T-cell receptor transgenic mice have provided evidence for clonal deletion of virus-specific T cells in persistently infected hosts and for selection of T-cell-resistant virus v...

journal_title：Current opinion in immunology

authors： Yanagi Y

更新日期：1991-08-01 00:00:00

abstract：:While certain bacteria and respiratory viruses promote local inflammation and disease onset, a more diverse colonization of the different species in the (gut) microbiome may be linked to more regulatory responses and protection against asthma and allergies. These processes are also influenced in part by food intake, b...

journal_title：Current opinion in immunology

authors： Smits HH,van der Vlugt LE,von Mutius E,Hiemstra PS

更新日期：2016-10-01 00:00:00

abstract：:Significant advances in research on the immunopathogenesis of leishmaniasis include the discovery of novel putative evasion and survival strategies of Leishmania parasites, a more detailed understanding of the function and regulation of interleukin-12, definition of molecules involved in cognate interaction between ma...

journal_title：Current opinion in immunology

authors： Bogdan C,Gessner A,Solbach W,Röllinghoff M

更新日期：1996-08-01 00:00:00

abstract：:The field of Type 1 diabetes research has been quick to embrace the era of translational medicine in the recent epoch. Building upon some 30 years of intense immunological research, the past decade has been marked by a series of clinical trials designed to evaluate the potential beneficial effects of a range of immune...

journal_title：Current opinion in immunology

authors： Roep BO,Peakman M

更新日期：2011-12-01 00:00:00

abstract：:Rheumatoid arthritis is often considered to be an autoimmune disease in which the abnormal immunological response is triggered by an infectious agent(s) but progress towards identifying such extrinsic factors has so far been unrevealing. In contrast, the genetic component of host susceptibility is slowly becoming clea...

journal_title：Current opinion in immunology

authors： Wordsworth P

更新日期：1992-12-01 00:00:00

abstract：:Cancer results from a tumor cell intrinsic dysregulation of oncogenes, tumor suppressor and stability genes as well as from the avoidance of immunosurveillance. A complex network of cellular interactions allows one to mount cognate anti-tumor immune responses. Recently, discoveries have been made regarding the links b...

journal_title：Current opinion in immunology

authors： Ghiringhelli F,Apetoh L,Housseau F,Kroemer G,Zitvogel L

更新日期：2007-04-01 00:00:00

abstract：:A little more than a decade after the explosion of research into recombinant live-attenuated or replication-deficient viruses as vaccine platforms, many viral vector-based vaccines have been licensed for animals. Progress has been slower for humans but 2011 will see the licensure of the first viral-vectored vaccine fo...

journal_title：Current opinion in immunology

authors： Rollier CS,Reyes-Sandoval A,Cottingham MG,Ewer K,Hill AV

更新日期：2011-06-01 00:00:00

abstract：:In normal hematopoiesis, differentiation and maturation of cell populations belonging to various lineages are tightly regulated by the interaction of many transcription factors. The relative numbers of different myeloid cells depends on their proliferative/apoptotic rate, while their identity relates to their recruitm...

journal_title：Current opinion in immunology

authors： Sonda N,Chioda M,Zilio S,Simonato F,Bronte V

更新日期：2011-04-01 00:00:00

abstract：:Clinical and experimental data now clearly indicate that chronic inflammation significantly contributes to cancer development. Emerging out of these studies is an appreciation that persistent humoral immune responses exacerbate recruitment and activation of innate immune cells in neoplastic microenvironments where the...

journal_title：Current opinion in immunology

authors： Tan TT,Coussens LM

更新日期：2007-04-01 00:00:00

abstract：:The germinal centre (GC) is a specialized cellular structure that forms in response to antigenic stimulation. It generates long-term humoral immunity through the production of memory B cells and long-lived antibody-secreting plasma cells. Conventional GCs form within secondary lymphoid organs, where networks of specia...

journal_title：Current opinion in immunology

authors： Silva-Cayetano A,Linterman MA

更新日期：2020-04-20 00:00:00

abstract：:The recent discovery of PTPN22 as a novel susceptibility gene in human type 1 diabetes and continued progress in defining genes in animal models of the disease mark a fruitful period in the field of type 1 diabetes genetics. In addition, the similarities of the genetic and functional aspects across species have been s...

journal_title：Current opinion in immunology

authors： Maier LM,Wicker LS

更新日期：2005-12-01 00:00:00

abstract：:Over two decades of research have increased the interest in factors from the tumor necrosis factor family. The vast majority of these factors are powerful modulators of critical immune functions and participate in pathogenic mechanisms leading to autoimmune disease. This field constantly evolves with the addition of n...

journal_title：Current opinion in immunology

authors： Mackay F,Kalled SL

更新日期：2002-12-01 00:00:00

abstract：:The commensal bacteria normally resident in the gastrointestinal tract represent an enormous pool of foreign antigen within the body. Although mechanical barriers limit entry of bacteria into the host, recent data suggest that T cells routinely interact with commensal bacteria using both antigen-specific and non-speci...

journal_title：Current opinion in immunology

authors： Nutsch KM,Hsieh CS

更新日期：2012-08-01 00:00:00

abstract：:Viruses that establish persistent infections in their host, such as herpesviruses, adenoviruses or HIV, express proteins designed to pre-empt or evade recognition and elimination by MHC class I restricted CD8+ T lymphocytes. Notable discoveries during the annual period of review have demonstrated that, in principle, e...

journal_title：Current opinion in immunology

authors： Hengel H,Koszinowski UH

更新日期：1997-08-01 00:00:00