Abstract:
:Viruses that establish persistent infections in their host, such as herpesviruses, adenoviruses or HIV, express proteins designed to pre-empt or evade recognition and elimination by MHC class I restricted CD8+ T lymphocytes. Notable discoveries during the annual period of review have demonstrated that, in principle, each single step within the MHC class I pathway of antigen processing and presentation is fair game for manipulation by viral functions. The viral factors that are natural inhibitors of this pathway have been instrumental for the elucidation of the distinct molecular mechanisms that are exploited by viruses. The viral stealth strategies that downregulate MHC class I protein surface expression may lead, however, to a higher susceptibility of virus-infected cells to natural killer cell activity. Strikingly, there is evidence that some viruses counteract increased natural killer cell recognition by expressing viral MHC class I homologues that function as surrogate inhibitors of natural killer cell activity.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Hengel H,Koszinowski UHdoi
10.1016/s0952-7915(97)80097-0subject
Has Abstractpub_date
1997-08-01 00:00:00pages
470-6issue
4eissn
0952-7915issn
1879-0372pii
S0952-7915(97)80097-0journal_volume
9pub_type
杂志文章,评审abstract::The IL-17/IL-17 receptor family is the newest and least understood of the cytokine subclasses. Composed of ligands IL-17A-IL-17F and receptors IL-17RA-IL-17RE, these cytokines have many unique structural and functional features. Since the discovery of the 'Th17' subset in 2005, particular attention has been paid to IL...
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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pub_type: 杂志文章,评审
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更新日期:1998-10-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:2012-08-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:2004-02-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:2009-04-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:1992-10-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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abstract::Gene therapy has become an attractive alternative therapeutic strategy to allogeneic transplant for primary immunodeficiencies (PIDs) owing to known genetic defects. Clinical trials using gammaretroviral vectors have demonstrated the proof of principle of gene therapy for Wiskott-Aldrich syndrome (WAS) and chronic gra...
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abstract::Killer Ig-like receptors (KIRs) are surface inhibitory receptors specific for allelic forms of human leukocyte antigen (HLA) class I molecules, which are expressed by natural killer (NK) cells and a subset of T lymphocytes. Upon engagement with HLA class I molecules, KIRs block NK cell activation and function. Cells l...
journal_title:Current opinion in immunology
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abstract::Allergen immunotherapy leads to tolerance through multiple mechanisms that include tolerogenic dendritic cells and T and B regulatory cells. These induced cellular populations produce mediators to skew the immune response to a tolerogenic milieu that, among others, results in IgG4 blocking antibodies formation and low...
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abstract::Zika virus (ZIKV) is the most recent mosquito-transmitted virus to cause a global health crisis following its entrance into a naïve population in the Western Hemisphere. Once the ZIKV outbreak began investigators rapidly established small and large animal models of pathogenesis, developed a number candidate vaccines u...
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