Abstract：
:While the role of PD-1 in inhibiting immunity during chronic infections is well established, its functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T cell responses during some acute infections and restrain responses by 'helpless' CD8 memory T cells. An emerging role for PD-1 in innate immunity has been revealed by recent studies showing that PD-1 can limit function of DC and macrophages as well as T cell independent B cell responses. Thus, PD-1 can influence adaptive immune responses during acute infections, though precisely how this regulation occurs is only just beginning to be appreciated.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Brown KE,Freeman GJ,Wherry EJ,Sharpe AHdoi
10.1016/j.coi.2010.03.007subject
Has Abstractpub_date
2010-06-01 00:00:00pages
397-401issue
3eissn
0952-7915issn
1879-0372pii
S0952-7915(10)00062-2journal_volume
22pub_type
杂志文章,评审abstract：:The eosinophil is regarded as a key mediator of the pathology and abnormal physiology of bronchial asthma. Current investigations are directed at understanding how eosinophils are attracted into the respiratory tract and how they bring about the abnormalities characteristic of this disease. ...
journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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