Innate receptors and microbes in induction of autoimmunity.

Abstract:

:Cells of the adaptive immune system (T and B cells) causing autoimmunity require activation signals that are normally provided by the innate immune system. Innate signaling receptors are obvious candidates for participation in the induction of autoimmunity, and the nature of these receptors suggests that microbes could be the triggers. Recent publications describing the development of autoimmunity in sterile conditions and in animals deficient in innate signaling question the requirement of these receptors for initiation of autoimmunity. In addition, the role of the non-pathogenic (commensal) microbiota as a regulator of autoimmunity has come into the spotlight. In this review we discuss recent reports that deal with the link between innate signaling receptors and 'adaptive' autoimmunity.

journal_name

Curr Opin Immunol

authors

Chervonsky A

doi

10.1016/j.coi.2009.08.003

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

641-7

issue

6

eissn

0952-7915

issn

1879-0372

pii

S0952-7915(09)00172-1

journal_volume

21

pub_type

杂志文章,评审
  • Peptide-based cancer vaccines.

    abstract::The application of molecularly defined vaccines composed of a limited number of tumor-specific T cell epitopes has resulted in protective antitumor T cell immunity in several mouse tumor models. The first encouraging results with such vaccines have been obtained in human beings. The development of the next generation ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0952-7915(96)80081-1

    authors: Melief CJ,Offringa R,Toes RE,Kast WM

    更新日期:1996-10-01 00:00:00

  • Chemokines in lymphopoiesis and lymphoid organ development.

    abstract::An important role has emerged for chemokines in regulating the distribution of progenitor cells during hematopoietic cell development. As well as recruiting cells, chemokines promote cell retention and cytokine expression. Furthermore, chemokines have been found to have an inductive function in secondary lymphoid orga...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0952-7915(00)00201-6

    authors: Ansel KM,Cyster JG

    更新日期:2001-04-01 00:00:00

  • Stromal cell control of conventional and ectopic germinal centre reactions.

    abstract::The germinal centre (GC) is a specialized cellular structure that forms in response to antigenic stimulation. It generates long-term humoral immunity through the production of memory B cells and long-lived antibody-secreting plasma cells. Conventional GCs form within secondary lymphoid organs, where networks of specia...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2020.03.007

    authors: Silva-Cayetano A,Linterman MA

    更新日期:2020-04-20 00:00:00

  • Recent advances in mucosal vaccines and adjuvants.

    abstract::Mucosal vaccines may be used both to prevent mucosal infections through the activation of antimicrobial immunity and to treat systemic inflammatory diseases through the induction of antigen-specific mucosal tolerance. New, efficient mucosal adjuvants for human use have been designed based on, amongst others, bacterial...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0952-7915(02)00384-9

    authors: Eriksson K,Holmgren J

    更新日期:2002-10-01 00:00:00

  • Animal models of mucosal inflammation and their relation to human inflammatory bowel disease.

    abstract::Animal models of inflammatory bowel disease (IBD) have been useful in the identification of those immune responses uniquely involved in IBD pathogenesis and in defining the important roles of environmental influences, such as normal luminal bacterial flora and the genetic composition of the host, in modifying IBD-asso...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0952-7915(99)00032-1

    authors: Blumberg RS,Saubermann LJ,Strober W

    更新日期:1999-12-01 00:00:00

  • Trafficking of MHC class II molecules in the late secretory pathway.

    abstract::Antigen presenting cells (APCs) alert the immune system to attack by extracellular organisms; APCs achieve this via internalization, degradation, and display of antigenic fragments on the cell surface by MHC class II molecules. These class II molecules bind to an accessory protein, termed the invariant chain, that ens...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0952-7915(01)00295-3

    authors: Hiltbold EM,Roche PA

    更新日期:2002-02-01 00:00:00

  • Food allergy.

    abstract::Food allergy is now known to encompass a number of distinct clinical entities that follow the ingestion of specific food or food additives. Research continues to shed light on immediate reactions to foods and food protein-induced enterocolitis of newborns and infants. Adverse reactions to food additives remain an area...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0952-7915(05)80007-x

    authors: Metcalfe DD

    更新日期:1991-12-01 00:00:00

  • Inflammation, ageing and chronic disease.

    abstract::Acute inflammatory responses are essential for pathogen control and tissue repair but can also cause severe collateral damage. Tight regulation of the response is required to minimize host injury, but in the face of chronic infections and age-associated immune dysregulation, inflammatory processes may exert multiple d...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2014.03.007

    authors: Pawelec G,Goldeck D,Derhovanessian E

    更新日期:2014-08-01 00:00:00

  • Peanut allergy and anaphylaxis.

    abstract::Peanuts are a frequent cause of food allergy and the most common cause of fatal food-induced anaphylaxis in the U.S. Advances during the past two years have promoted our understanding of peanut allergens and peanut allergy prevalence, etiology, diagnosis, and therapy. The advances highlighted in this review include ev...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2010.10.005

    authors: Finkelman FD

    更新日期:2010-12-01 00:00:00

  • Predisposed αβ T cell antigen receptor recognition of MHC and MHC-I like molecules?

    abstract::The diverse αβ T cell receptor (TCR) repertoire exhibits versatility in its ability to generate antigen (Ag) receptors capable of interacting with polymorphic Major Histocompatibility Complex (MHC) molecules and monomorphic MHC-I like molecules, including the CD1 and MR1 families. Collectively, these evolutionarily re...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2013.07.010

    authors: Eckle SB,Turner SJ,Rossjohn J,McCluskey J

    更新日期:2013-10-01 00:00:00

  • Neuronal regulation of innate lymphoid cells.

    abstract::The cardinal signs of inflammation suggest a close connection between the nervous system and the immune system. However, the cellular and molecular basis of these interactions remains incompletely defined. Recent research has demonstrated that tissue-resident innate lymphoid cells (ILCs) obtain neuronal signals, parti...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.11.002

    authors: Klose CS,Artis D

    更新日期:2019-02-01 00:00:00

  • Therapeutic intervention with inhibitors of co-stimulatory pathways in autoimmune disease.

    abstract::Many humanized antibodies and fusion proteins targeting T-cell co-stimulatory molecules are now in late-stage clinical development (phase II, phase III) or have recently completed phase III clinical trials. Both Amevive, an LFA-3-Ig fusion protein targeting CD2, and Xanelim, a humanized anti-CD11a antibody, have shown...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0952-7915(01)00279-5

    authors: Aruffo A,Hollenbaugh D

    更新日期:2001-12-01 00:00:00

  • T cells and cytokines in Crohn's disease.

    abstract::Recent findings indicate that activated T lymphocytes, showing restricted T-cell receptor repertoire and a Th1-like profile of cytokine production, are responsible for macrophage activation and release of inflammatory cytokines, toxic oxygen metabolites and nitric oxide, which initiate and maintain the transmural inte...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0952-7915(97)80180-x

    authors: Romagnani P,Annunziato F,Baccari MC,Parronchi P

    更新日期:1997-12-01 00:00:00

  • The purinergic P2X7 ion channel receptor-a 'repair' receptor in bone.

    abstract::A strong skeleton relies on adaptation to varying physical demands and on maintenance of the bone tissue in order to avoid accumulation of micro-damage. In bone, the purinergic P2X7 ion channel receptor is expressed on both cells of the stromal lineage such as the bone forming osteoblasts and the mechano-sensing osteo...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2018.03.016

    authors: Jørgensen NR

    更新日期:2018-06-01 00:00:00

  • Plant innate immunity - direct and indirect recognition of general and specific pathogen-associated molecules.

    abstract::Plants have the capacity to recognise and reject pathogens at various stages of their attempted colonisation of the plant. Non-specific rejection often arises as a consequence of the potential pathogen's attempt to breach the first lines of plant defence. Pathogens able to penetrate beyond this barrier of non-host res...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2003.11.016

    authors: Jones DA,Takemoto D

    更新日期:2004-02-01 00:00:00

  • Antigen presentation by dendritic cells in vivo.

    abstract::Dendritic cells (DC) are heterogenous, comprising several subpopulations of migratory and lymphoid-organ-resident types. Recent studies addressing the role of each subset in antigen presentation in vivo have revealed a complex division of labor within the DC network. In addition to CD8(+) DC, migratory lung or dermal ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2009.03.011

    authors: Segura E,Villadangos JA

    更新日期:2009-02-01 00:00:00

  • CD14-dependent clearance of apoptotic cells: relevance to the immune system.

    abstract::Until very recently, the function of CD14 was thought to be limited to innate immune responses to bacterial and other microbial structures. It is now known that macrophage CD14 serves an additional unexpected function, namely as a receptor involved in the recognition and phagocytosis of cells undergoing apoptosis. In ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0952-7915(99)00047-3

    authors: Gregory CD

    更新日期:2000-02-01 00:00:00

  • In vivo antigen presentation.

    abstract::Monoclonal antibodies specific for defined peptide-MHC complexes are now being used to physically detect T-cell receptor ligands. These reagents have resulted in the identification of the cells that present antigen in lymphoid and non-lymphoid tissues after various forms of antigen administration. In addition, recent ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2003.11.001

    authors: Germain RN,Jenkins MK

    更新日期:2004-02-01 00:00:00

  • Killer immunoglobulin-like receptors.

    abstract::Killer Ig-like receptors (KIRs) are surface inhibitory receptors specific for allelic forms of human leukocyte antigen (HLA) class I molecules, which are expressed by natural killer (NK) cells and a subset of T lymphocytes. Upon engagement with HLA class I molecules, KIRs block NK cell activation and function. Cells l...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2004.07.010

    authors: Moretta L,Moretta A

    更新日期:2004-10-01 00:00:00

  • Selection in the germinal center.

    abstract::Germinal centers (GCs) are well known for their important role in shaping the secondary B cell repertoire to generate antibodies capable of binding with high-affinity and specificity to foreign antigens. Somatic hypermutation of the Ig variable region genes in GC B cells represents a highly efficient mechanism for gen...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2019.11.001

    authors: Lau AW,Brink R

    更新日期:2020-04-01 00:00:00

  • HIV types and testing.

    abstract::The past year has seen the discovery of new isolates which do not readily fit into the established categories HIV-1, HIV-2 and SIV, as well as the availability of new assays including the use of the polymerase chain reaction. New combination enzyme-linked immunosorbent assays can detect viruses from two or more groups...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/0952-7915(91)90018-v

    authors: Dalgleish AG

    更新日期:1991-08-01 00:00:00

  • Rheumatoid arthritis.

    abstract::Rheumatoid arthritis is often considered to be an autoimmune disease in which the abnormal immunological response is triggered by an infectious agent(s) but progress towards identifying such extrinsic factors has so far been unrevealing. In contrast, the genetic component of host susceptibility is slowly becoming clea...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/0952-7915(92)90059-n

    authors: Wordsworth P

    更新日期:1992-12-01 00:00:00

  • Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter.

    abstract::Sensing of RNA virus infection by the RIG-I-like receptors (RLRs) engages a complex signaling cascade that utilizes the mitochondrial antiviral signaling (MAVS) adapter protein to orchestrate the innate host response to pathogen, ultimately leading to the induction of antiviral and inflammatory responses mediated by t...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2011.08.001

    authors: Belgnaoui SM,Paz S,Hiscott J

    更新日期:2011-10-01 00:00:00

  • Initiation of autoimmunity.

    abstract::It has recently become clear that several factors must coincide for the initiation of autoimmunity. At minimum, these involve a genetic predisposition, naive lymphocytes that can react with autoantigens and a precipitating event that leads to T and/or B cell activation. Inter-individual variations in these factors pro...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2004.09.002

    authors: Christen U,von Herrath MG

    更新日期:2004-12-01 00:00:00

  • Regulation of immunological memory.

    abstract::Immunological memory can be regulated during either its development or its maintenance phases. Controversy and confusion surround both methods of regulation, especially in the field of T-cell memory. Recent work has helped in improving our definition of 'a memory cell', but this has been complicated by another major p...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/0952-7915(94)90122-8

    authors: Gray D

    更新日期:1994-06-01 00:00:00

  • Unraveling immunity to gamma-herpesviruses: a new model for understanding the role of immunity in chronic virus infection.

    abstract::Murine gamma-herpesvirus 68 (gammaHV68) infection is a new model for understanding how immunity and chronic gamma-herpesvirus infection inter-relate. gammaHV68 is closely related to the human Epstein-Barr virus and Kaposi's sarcoma herpesvirus and is associated with tumors, vasculitis of the great elastic arteries and...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0952-7915(99)80063-6

    authors: Virgin HW,Speck SH

    更新日期:1999-08-01 00:00:00

  • Regulatory T cells in stem cell transplantation: strategies and first clinical experiences.

    abstract::The adoptive transfer of donor-type CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) protects from graft-versus-host disease in murine bone marrow transplantation models. Results from first clinical trials exploring such strategies have recently been presented and seem to confirm the efficacy of Treg for the prevention...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2011.06.006

    authors: Edinger M,Hoffmann P

    更新日期:2011-10-01 00:00:00

  • Genomic and proteomic analysis of multiple sclerosis. Opinion.

    abstract::Multiple sclerosis (MS) and other autoimmune diseases result from the dysregulation of genetic and proteomic programs. In MS, the loss of immune homeostasis leads to aberrant targeting and destruction of the myelin sheath, which manifests as the clinical syndrome of MS. The advent of technologies to perform large-scal...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章

    doi:10.1016/j.coi.2003.09.015

    authors: Robinson WH,Utz PJ,Steinman L

    更新日期:2003-12-01 00:00:00

  • Thymic development and peripheral homeostasis of regulatory T cells.

    abstract::The development and maintenance of regulatory T (T-reg) cells is crucial for determining the level of reactivity in the immune system. Until recently, however, surprisingly little was known about the factors involved in the development of these cells in the thymus or the mechanisms that maintain them in the periphery....

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2007.02.005

    authors: Liston A,Rudensky AY

    更新日期:2007-04-01 00:00:00

  • Transcriptional mechanisms that regulate T helper 1 cell differentiation.

    abstract::Recent research has made great strides in uncovering the mechanisms by which the T helper 1 (Th1) cell gene expression program is established. In particular, studies examining the transcription factors T-bet, STAT1, and STAT4 have elucidated their roles in regulating Th1 signature genes, including Ifng, and have start...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coi.2011.12.004

    authors: Oestreich KJ,Weinmann AS

    更新日期:2012-04-01 00:00:00