Abstract:
:Our understanding of the X-linked lymphoproliferative syndrome (XLP) has advanced significantly in the past two years. The gene that is aberrant in the condition - SH2D1A/SAP, which encodes SAP (signaling lymphocytic activation molecule [SLAM]-associated protein) - was cloned, the crystal structure of its product was solved and insights into the signaling mechanisms of this small SH2-domain-containing protein via the cell surface receptors SLAM and 2B4 have been provided. SAP mutation, and not Epstein-Barr virus infection per se, may be critical for XLP.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Howie D,Sayos J,Terhorst C,Morra Mdoi
10.1016/s0952-7915(00)00123-0subject
Has Abstractpub_date
2000-08-01 00:00:00pages
474-8issue
4eissn
0952-7915issn
1879-0372pii
S0952-7915(00)00123-0journal_volume
12pub_type
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journal_title:Current opinion in immunology
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