Regulation of transcription of MHC class II genes.

abstract：:Gene expression variation is critical for the normal development and physiology of immune cells. Using cDNA microarrays, a systematic, genomic-scale view of gene expression in immune cells at many stages of differentiation and activation can be obtained. From the high vantagepoint provided by this technology, the gene...

journal_title：Current opinion in immunology

authors： Alizadeh AA,Staudt LM

更新日期：2000-04-01 00:00:00

abstract：:Perforin defects have been identified in humans with familial hematophagocytic lymphohistiocytosis. The pathology of these patients has dramatically illustrated an under-appreciated role for perforin in the regulation of T-cell responses in vivo, and experimental studies are shedding light on the mechanisms involved. ...

journal_title：Current opinion in immunology

authors： Catalfamo M,Henkart PA

更新日期：2003-10-01 00:00:00

abstract：:Graft versus host disease (GVHD) remains the major obstacle to the application of bone marrow transplantation across HLA barriers. Recent advances in our understanding of GVHD pathophysiology have resulted in the evaluation in animal models and in clinical trials of some novel approaches to avoiding and treating GVHD....

journal_title：Current opinion in immunology

authors： Sykes M

更新日期：1993-10-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease that causes most heart attacks and strokes, making it the biggest killer in the world. Although cholesterol-lowering drugs have dramatically reduced these major adverse cardiovascular events, there remains a high residual risk called inflammatory risk. Atherosclerosis ...

journal_title：Current opinion in immunology

authors： Kobiyama K,Saigusa R,Ley K

更新日期：2019-08-01 00:00:00

abstract：:Hybrid resistance refers to the rejection of parental strain bone marrow cells by natural killer cells of mice that are F1 hybrids derived from two inbred parental strains. This pattern of rejection is not seen in solid organ transplants. Progress in understanding this exception to the laws of transplantation genetics...

journal_title：Current opinion in immunology

authors： Kumar V,George T,Yu YY,Liu J,Bennett M

更新日期：1997-02-01 00:00:00

abstract：:Many of the pathogens that cause human infectious diseases do not infect rodents or other mammalian species. Small animal models that allow studies of the pathogenesis of these agents and evaluation of drug efficacy are critical for identifying ways to prevent and treat human infectious diseases. Immunodeficient mice ...

journal_title：Current opinion in immunology

authors： Brehm MA,Jouvet N,Greiner DL,Shultz LD

更新日期：2013-08-01 00:00:00

abstract：:Analysis of the T-cell receptor has revealed the molecular basis of antigen recognition by T cells specific for viral antigens. Studies using T-cell receptor transgenic mice have provided evidence for clonal deletion of virus-specific T cells in persistently infected hosts and for selection of T-cell-resistant virus v...

journal_title：Current opinion in immunology

authors： Yanagi Y

更新日期：1991-08-01 00:00:00

abstract：:Rational selection of individual adjuvants can often be made on the basis of innate molecular interactions of the foreign molecules with pattern recognition receptors such as Toll-like receptors. For example, monophosphoryl lipid A, a family of endotoxic TLR4 agonist molecules from bacteria, has recently been formulat...

journal_title：Current opinion in immunology

authors： Alving CR,Peachman KK,Rao M,Reed SG

更新日期：2012-06-01 00:00:00

abstract：:T cell exhaustion represents a continuous spectrum of cellular dysfunction induced during chronic viral infection, facilitating viral persistence and associating with poor clinical outcome. Modulation of T cell exhaustion can restore function in exhausted CD8 T cells, promoting viral clearance. Exhaustion has also bee...

journal_title：Current opinion in immunology

authors： McKinney EF,Smith KG

更新日期：2016-12-01 00:00:00

abstract：:T cell antigen receptor-induced signals are required for normal T cell development and function. Recent studies have investigated the mechanism(s) by which signals of different strengths are converted into distinct cellular fates during thymocyte development. These studies indicate the importance of the strength and d...

journal_title：Current opinion in immunology

authors： Love PE,Chan AC

更新日期：2003-04-01 00:00:00

abstract：:The steep rise in the incidence and prevalence of food allergy (FA) in the last few decades have focused attention of environmental mechanisms which act to promote disease, chief among which is the microbiome. Recent studies have now established the presence of pathogenic dysbiosis in FA that could be precipitated by ...

journal_title：Current opinion in immunology

authors： Stephen-Victor E,Chatila TA

更新日期：2019-10-01 00:00:00

abstract：:Allergen immunotherapy leads to tolerance through multiple mechanisms that include tolerogenic dendritic cells and T and B regulatory cells. These induced cellular populations produce mediators to skew the immune response to a tolerogenic milieu that, among others, results in IgG4 blocking antibodies formation and low...

journal_title：Current opinion in immunology

authors： Mitsias DI,Xepapadaki P,Makris M,Papadopoulos NG

更新日期：2020-10-01 00:00:00

abstract：:The molecular repertoire for innate recognition of bacterial pathogens has expanded rapidly in the past decade. These immunosensors include Toll-like receptors and the more recently defined NOD-like receptors (NLRs): NODs, NALPs, NAIP and IPAF. Toll-like receptors signal from the cell surface or endosome upon ligand b...

journal_title：Current opinion in immunology

authors： Delbridge LM,O'Riordan MX

更新日期：2007-02-01 00:00:00

abstract：:The commensal bacteria normally resident in the gastrointestinal tract represent an enormous pool of foreign antigen within the body. Although mechanical barriers limit entry of bacteria into the host, recent data suggest that T cells routinely interact with commensal bacteria using both antigen-specific and non-speci...

journal_title：Current opinion in immunology

authors： Nutsch KM,Hsieh CS

更新日期：2012-08-01 00:00:00

abstract：:NKT cells utilize a restricted alphabeta TCR repertoire that recognizes glycolipids in association with CD1d. The recent development of fluorescent CD1d tetramers loaded with the synthetic glycolipid alpha-galactosyl-ceramide has led to a clearer definition of NKT-cell subsets as well as important insights into their ...

journal_title：Current opinion in immunology

authors： MacDonald HR

更新日期：2002-04-01 00:00:00

abstract：:Asthma, one of the most common chronic diseases, is a complex and heterogeneous disorder. The results of genome screens for asthma-related traits in 11 different populations identified at least 18 regions of the genome that probably house asthma/atopy genes. The most consistently replicated regions are on chromosomes ...

journal_title：Current opinion in immunology

authors： Hoffjan S,Ober C

更新日期：2002-12-01 00:00:00

abstract：:The hallmark of the innate immune response of higher insects is the rapid and transient synthesis of a battery of broad spectrum antimicrobial peptides by the fat body. The control of the genes encoding these peptides involves cis-regulatory promoter elements homologous to sequences functional in mammalian acute-phase...

journal_title：Current opinion in immunology

authors： Hoffmann JA,Reichhart JM,Hetru C

更新日期：1996-02-01 00:00:00

abstract：:Recent research developments support the following views regarding antigen recognition in autoimmune demyelinating disease: there may be no single autoimmune target protein; diverse peptide self-determinants from multiple myelin proteins can be recognized; target determinant epitopes may differ among individuals; and ...

journal_title：Current opinion in immunology

authors： Tuohy VK,Fritz RB,Ben-Nun A

更新日期：1994-12-01 00:00:00

abstract：:Defining the immunological goals for respiratory syncytial virus (RSV) vaccination requires understanding of RSV biology and tropism, mechanisms of cell-to-cell spread and immunity, epidemiology, and transmission dynamics. The immunological goals for a particular vaccine would be product-specific based on antigen sele...

journal_title：Current opinion in immunology

authors： Graham BS

更新日期：2019-08-01 00:00:00

abstract：:The past few years have seen significant growth in the number of known chemokines. Along with expansion in this field has come an appreciation of a role for chemokines beyond the chemotaxis of leukocytes. In particular, it appears that these molecules may represent major products of activated lymphocytes and that, in ...

journal_title：Current opinion in immunology

authors： Hedrick JA,Zlotnik A

更新日期：1996-06-01 00:00:00

abstract：:Induction of antiviral immunity in vertebrates and invertebrates relies on members of the RIG-I-like receptor and Dicer families, respectively. Although these proteins have different size and domain composition, members of both families share a conserved DECH-box helicase domain. This helicase, also known as a duplex ...

journal_title：Current opinion in immunology

authors： Paro S,Imler JL,Meignin C

更新日期：2015-02-01 00:00:00

abstract：:While certain bacteria and respiratory viruses promote local inflammation and disease onset, a more diverse colonization of the different species in the (gut) microbiome may be linked to more regulatory responses and protection against asthma and allergies. These processes are also influenced in part by food intake, b...

journal_title：Current opinion in immunology

authors： Smits HH,van der Vlugt LE,von Mutius E,Hiemstra PS

更新日期：2016-10-01 00:00:00

abstract：:Consolidating the information that we have on pharmacogenetics and on cytokine genetics to produce patient-oriented individualized drug regimens is an important challenge in transplantation medicine. Using a multi-variant approach based on genetic profile and other relevant clinical factors a score system may be devel...

journal_title：Current opinion in immunology

authors： Girnita DM,Burckart G,Zeevi A

更新日期：2008-10-01 00:00:00

abstract：:Immunity to intracellular pathogens and cancer relies on the generation of robust CD8(+) T cell effector responses as well as the establishment of immunological memory. During a primary immune response CD8(+) T cells experience diverse extracellular environmental cues and cell-cell interactions that trigger downstream...

journal_title：Current opinion in immunology

authors： Thaventhiran JE,Fearon DT,Gattinoni L

更新日期：2013-06-01 00:00:00

abstract：:Much has been learned recently about the structure and function of 55 kDa bactericidal/permeability-increasing protein (BPI), a member of a genomically conserved lipid-interactive protein family. Analysis of BPI fragments and the crystal structure of human BPI have established that BPI consists of two functionally dis...

journal_title：Current opinion in immunology

authors： Elsbach P,Weiss J

更新日期：1998-02-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) persists within the host in the presence of concomitant immunity by establishing a latent infection within sensory neurons. HSV-1 latency is widely viewed as a neuron-enforced quiescent state of the virus, in which a lack of viral protein synthesis prevents recognition of the infect...

journal_title：Current opinion in immunology

authors： Khanna KM,Lepisto AJ,Decman V,Hendricks RL

更新日期：2004-08-01 00:00:00

abstract：:Many recent studies suggest an involvement of gamma delta T cells in the immune response to infectious pathogens including viruses, bacteria and eukaryotic parasites. However, it remains unclear whether the responses of gamma delta T cells are specifically directed against antigens derived from these pathogens or agai...

journal_title：Current opinion in immunology

authors： Born WK,Harshan K,Modlin RL,O'Brien RL

更新日期：1991-08-01 00:00:00

abstract：:Our understanding of the X-linked lymphoproliferative syndrome (XLP) has advanced significantly in the past two years. The gene that is aberrant in the condition - SH2D1A/SAP, which encodes SAP (signaling lymphocytic activation molecule [SLAM]-associated protein) - was cloned, the crystal structure of its product was ...

journal_title：Current opinion in immunology

authors： Howie D,Sayos J,Terhorst C,Morra M

更新日期：2000-08-01 00:00:00

abstract：:Many humanized antibodies and fusion proteins targeting T-cell co-stimulatory molecules are now in late-stage clinical development (phase II, phase III) or have recently completed phase III clinical trials. Both Amevive, an LFA-3-Ig fusion protein targeting CD2, and Xanelim, a humanized anti-CD11a antibody, have shown...

journal_title：Current opinion in immunology

authors： Aruffo A,Hollenbaugh D

更新日期：2001-12-01 00:00:00

abstract：:Dendritic cells are responsible for directing different types of T cell responses, from thymic negative selection to the generation of effector and memory cells and the induction of peripheral tolerance. Recent studies indicate that the dendritic cell lineage, the extent of recruitment into inflamed tissues and migrat...

journal_title：Current opinion in immunology

authors： Lanzavecchia A,Sallusto F

更新日期：2001-06-01 00:00:00