Perforin and the granule exocytosis cytotoxicity pathway.


:Perforin defects have been identified in humans with familial hematophagocytic lymphohistiocytosis. The pathology of these patients has dramatically illustrated an under-appreciated role for perforin in the regulation of T-cell responses in vivo, and experimental studies are shedding light on the mechanisms involved. The detailed molecular mechanisms of perforin's mandatory role in the cytotoxic T lymphocyte (CTL)-mediated granule exocytosis death pathway and of granzyme entry into target cells remain unclear. In model systems measuring apoptosis by granzyme B and sublytic perforin, pore formation is undetectable during granzyme entry. Selfprotection of cytotoxic lymphocytes after degranulation can be explained by surface expression of the granule protease cathepsin B, as shown by suicidal degranulation in the presence of specific inhibitors.


Curr Opin Immunol


Catalfamo M,Henkart PA




Has Abstract


2003-10-01 00:00:00














  • Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice.

    abstract::The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants - and, in a few cases, B cell determinants - have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least thr...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Abraham RS,David CS

    更新日期:2000-02-01 00:00:00

  • Adjuvants for human vaccines.

    abstract::Rational selection of individual adjuvants can often be made on the basis of innate molecular interactions of the foreign molecules with pattern recognition receptors such as Toll-like receptors. For example, monophosphoryl lipid A, a family of endotoxic TLR4 agonist molecules from bacteria, has recently been formulat...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Alving CR,Peachman KK,Rao M,Reed SG

    更新日期:2012-06-01 00:00:00

  • Tolerance to the foeto-placental 'graft': ten ways to support a child for nine months.

    abstract::Tolerance to the foetal 'allograft' has been extensively studied in the past few years, providing interesting new insights. In addition to a potential role for HLA-G, which has been widely discussed, there are hypotheses suggesting roles for several other molecules or cells: leukemia inhibitory factor and its receptor...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Thellin O,Coumans B,Zorzi W,Igout A,Heinen E

    更新日期:2000-12-01 00:00:00

  • Possible functions of tumor-associated carbohydrate antigens.

    abstract::Expression of some tumor-associated carbohydrate antigens may define the stage, rate and phenotype of tumor progression and may have prognostic value. Some of these antigens are now recognized as adhesion molecules that define the site of metastasis. Monoclonal antibodies to tumor-associated carbohydrate antigens, or ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Hakomori S

    更新日期:1991-10-01 00:00:00

  • Prospects for adoptive T cell therapy.

    abstract::Since the establishment of methods to isolate genes encoding cytotoxic T lymphocyte defined tumor antigens, several antigens have been identified and characterized for suitability as target antigens for immunotherapy. The development of innovative strategies to generate T cells targeting these antigens and lessons lea...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Yee C,Riddell SR,Greenberg PD

    更新日期:1997-10-01 00:00:00

  • Epigenetic regulation of antigen receptor gene rearrangement.

    abstract::Recent studies of the regulation of antigen receptor rearrangement have revealed several completely new levels of control. Not only do antigen receptor loci undergo changes in histone modifications as they become accessible for recombination, but also the number of different histone modifications and the variation at ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Feeney AJ

    更新日期:2011-04-01 00:00:00

  • Oncolytic viruses and immunity.

    abstract::Initially, direct oncolysis was thought to be the sole mechanism through which oncolytic viruses (OVs) exert their anti-tumor effect, and the immune system was perceived as the major obstacle in oncolytic virotherapy. Over the last decade, there has been a lot of debate on whether the immune system is a friend or foe ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Chaurasiya S,Chen NG,Fong Y

    更新日期:2018-04-01 00:00:00

  • The primary germinal center response in mice.

    abstract::The germinal center (GC) is an important anatomical site for the development of high affinity antibodies during T-cell dependent B cell responses. Although the importance of the GC response to humoral immunity is well known, much remains to be elucidated about GC induction, maintenance and regulation. Recent studies e...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Cozine CL,Wolniak KL,Waldschmidt TJ

    更新日期:2005-06-01 00:00:00

  • Viral vectors as vaccine platforms: deployment in sight.

    abstract::A little more than a decade after the explosion of research into recombinant live-attenuated or replication-deficient viruses as vaccine platforms, many viral vector-based vaccines have been licensed for animals. Progress has been slower for humans but 2011 will see the licensure of the first viral-vectored vaccine fo...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Rollier CS,Reyes-Sandoval A,Cottingham MG,Ewer K,Hill AV

    更新日期:2011-06-01 00:00:00

  • Sensing and clearance of apoptotic cells.

    abstract::Macrophages specifically engulf apoptotic cells but not healthy cells. Phosphatidylserine (PtdSer) is localized at the inner leaflet of plasma membranes as a result of the action of flippases (ATP11A and 11C). When cells undergo apoptosis, caspase 3 cleaves and inactivates the flippases, while simultaneously cleaving ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Nagata S,Segawa K

    更新日期:2020-08-24 00:00:00

  • The recognition of self-antigens and autoimmune disease.

    abstract::Recent studies have increased our understanding of the nature of autoimmune recognition and of the identity of autoantigens, at least in model systems. Knowledge of the autoantigens and the process of recognition is suggesting new therapies for autoimmune disease. ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Smith SC,Allen PM

    更新日期:1991-02-01 00:00:00

  • Transcription factors required for lymphoid lineage commitment.

    abstract::Intimate interactions between multipotential hemopoietic stem cells and their microenvironment work towards redefining the identity and the differentiative fate of these primitive cells. Molecular cues delivered by the microenvironment frequently act in an instructive fashion by initiating intracellular signaling path...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Georgopoulos K

    更新日期:1997-04-01 00:00:00

  • T cell exhaustion and immune-mediated disease-the potential for therapeutic exhaustion.

    abstract::T cell exhaustion represents a continuous spectrum of cellular dysfunction induced during chronic viral infection, facilitating viral persistence and associating with poor clinical outcome. Modulation of T cell exhaustion can restore function in exhausted CD8 T cells, promoting viral clearance. Exhaustion has also bee...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: McKinney EF,Smith KG

    更新日期:2016-12-01 00:00:00

  • Novel vaccine approaches for protection against intracellular pathogens.

    abstract::Vaccination against intracellular pathogens requires generation of a pool of memory T cells able to respond upon infection and mediate either killing of the infected cell or induce killing mechanisms in the infected cell. T cell-inducing vaccines must aim to target the antigen to antigen-presenting cells (APCs) so tha...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Griffiths KL,Khader SA

    更新日期:2014-06-01 00:00:00

  • Evolutionary vignettes of natural killer cell receptors.

    abstract::The discovery of novel immune receptors has led to a recent renaissance of research into the innate immune system, following decades of intense research of the adaptive immune system. Of particular interest has been the discovery of the natural killer (NK) cell receptors which, depending on type, interact with classic...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Sambrook JG,Beck S

    更新日期:2007-10-01 00:00:00

  • Sensing viral RNAs by Dicer/RIG-I like ATPases across species.

    abstract::Induction of antiviral immunity in vertebrates and invertebrates relies on members of the RIG-I-like receptor and Dicer families, respectively. Although these proteins have different size and domain composition, members of both families share a conserved DECH-box helicase domain. This helicase, also known as a duplex ...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Paro S,Imler JL,Meignin C

    更新日期:2015-02-01 00:00:00

  • Plant NLR-triggered immunity: from receptor activation to downstream signaling.

    abstract::Innate immune perception is the first line of inducible defense against invading pathogens. Plants lack specialized circulating immune cells. Therefore, diverse cell types are able to recognize and respond to pathogens. Surface-localized and intracellular plant innate immune receptors are capable of recognizing divers...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Lolle S,Stevens D,Coaker G

    更新日期:2020-02-01 00:00:00

  • Spatial and functional heterogeneity of follicular helper T cells in autoimmunity.

    abstract::Follicular helper T cells provide signals that promote B cell development, proliferation, and production of affinity matured and appropriately isotype switched antibodies. In addition to their classical locations within B cell follicles and germinal centers therein, B cell helper T cells are also found in extrafollicu...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Seth A,Craft J

    更新日期:2019-12-01 00:00:00

  • Recognition of microbial infection by Toll-like receptors.

    abstract::The Toll-like receptors (TLRs) of the innate immune system detect host invasion by pathogens and initiate immune responses. All of the TLRs use the adaptor MyD88 to transduce a signal; however, two newly identified signaling molecules, TIRAP and TRIF, interact with a subset of the TLRs, suggesting a signaling specific...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Kopp E,Medzhitov R

    更新日期:2003-08-01 00:00:00

  • T cell-independent B cell memory.

    abstract::Despite being unable to mount a bona fide recall antibody (Ab) response to secondary immunization, T cell-independent antigens (TI Ag) such as pneumococcal capsular polysaccharides (PS) can generate protective humoral immunity in adults. The concept of TI B cell memory after being iconoclastic for decades has now rece...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Defrance T,Taillardet M,Genestier L

    更新日期:2011-06-01 00:00:00

  • Bullous skin diseases.

    abstract::Fundamental advances in the fields of molecular biology and immunology have facilitated investigation of the autoimmune blistering disorders. Recently, the use of human autoantibodies has helped to identify biologically important adhesion molecules of the skin, and the pathogenic mechanisms involved in bullous skin di...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Nousari HC,Anhalt GJ

    更新日期:1995-12-01 00:00:00

  • B cells and autoimmunity.

    abstract::There is a growing appreciation for the role for B cells in autoimmune disorders in which inflammation is driven by T cells, in addition to the well-established role for B cells in autoimmune disorders characterized by pathogenic auto-antibodies. Current information on tolerance checkpoints in B cells, B cell depletio...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Pillai S,Mattoo H,Cariappa A

    更新日期:2011-12-01 00:00:00

  • Recent advances in mucosal vaccines and adjuvants.

    abstract::Mucosal vaccines may be used both to prevent mucosal infections through the activation of antimicrobial immunity and to treat systemic inflammatory diseases through the induction of antigen-specific mucosal tolerance. New, efficient mucosal adjuvants for human use have been designed based on, amongst others, bacterial...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Eriksson K,Holmgren J

    更新日期:2002-10-01 00:00:00

  • A comparative review of aging and B cell function in mice and humans.

    abstract::Immune system function declines with age. Here we review and compare age-associated changes in murine and human B cell pools and humoral immune responses. We summarize changes in B cell generation and homeostasis, as well as notable changes at the subcellular level; then discuss how these changes help to explain alter...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Scholz JL,Diaz A,Riley RL,Cancro MP,Frasca D

    更新日期:2013-08-01 00:00:00

  • Peptidases trimming MHC class I ligands.

    abstract::Peptides presented by MHC class I molecules are typically produced through antigen degradation by the proteasome followed by trimming by exopeptidases. According to recent results, these include both aminopeptidases and carboxypeptidases in the cytosol and the endoplasmic reticulum. While cytosolic peptidases have a n...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Weimershaus M,Evnouchidou I,Saveanu L,van Endert P

    更新日期:2013-02-01 00:00:00

  • Interference with antigen processing by viruses.

    abstract::Viruses that establish persistent infections in their host, such as herpesviruses, adenoviruses or HIV, express proteins designed to pre-empt or evade recognition and elimination by MHC class I restricted CD8+ T lymphocytes. Notable discoveries during the annual period of review have demonstrated that, in principle, e...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Hengel H,Koszinowski UH

    更新日期:1997-08-01 00:00:00

  • Heterogeneity and fate choice: T cell exhaustion in cancer and chronic infections.

    abstract::CD8 T cell differentiation is a tightly regulated process generating effector and memory T cells over the course of acute infections. In cancer and chronic infection, this differentiation program is derailed, and antigen-specific CD8 T cells differentiate to a hyporesponsive state generally referred to as T cell exhau...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Philip M,Schietinger A

    更新日期:2019-06-01 00:00:00

  • Animal models of mucosal inflammation and their relation to human inflammatory bowel disease.

    abstract::Animal models of inflammatory bowel disease (IBD) have been useful in the identification of those immune responses uniquely involved in IBD pathogenesis and in defining the important roles of environmental influences, such as normal luminal bacterial flora and the genetic composition of the host, in modifying IBD-asso...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Blumberg RS,Saubermann LJ,Strober W

    更新日期:1999-12-01 00:00:00

  • The signaling tool box for tyrosine-based costimulation of lymphocytes.

    abstract::Triggering lymphocyte effector functions is controlled by a diverse array of immune cell coreceptors that dampen or potentiate the primary activation signal from antigen receptors. Attenuation of lymphocyte activation has been shown to be accomplished by immunoreceptor tyrosine-based inhibition motifs that upon phosph...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Engels N,Wienands J

    更新日期:2011-06-01 00:00:00

  • Role of murine NK cells and their receptors in hybrid resistance.

    abstract::Hybrid resistance refers to the rejection of parental strain bone marrow cells by natural killer cells of mice that are F1 hybrids derived from two inbred parental strains. This pattern of rejection is not seen in solid organ transplants. Progress in understanding this exception to the laws of transplantation genetics...

    journal_title:Current opinion in immunology

    pub_type: 杂志文章,评审


    authors: Kumar V,George T,Yu YY,Liu J,Bennett M

    更新日期:1997-02-01 00:00:00