Development and selection of NKT cells.

Abstract:

:NKT cells utilize a restricted alphabeta TCR repertoire that recognizes glycolipids in association with CD1d. The recent development of fluorescent CD1d tetramers loaded with the synthetic glycolipid alpha-galactosyl-ceramide has led to a clearer definition of NKT-cell subsets as well as important insights into their developmental origin. As many as four subsets may exist, differing in NK1.1 expression, TCR repertoire and dependence on CD1d and various glycolipids for development. Two different lineage-commitment models have been proposed, with most evidence favoring a byproduct of conventional-T-cell development.

journal_name

Curr Opin Immunol

authors

MacDonald HR

doi

10.1016/s0952-7915(02)00329-1

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

250-4

issue

2

eissn

0952-7915

issn

1879-0372

pii

S0952791502003291

journal_volume

14

pub_type

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