Abstract:
:Induction of antiviral immunity in vertebrates and invertebrates relies on members of the RIG-I-like receptor and Dicer families, respectively. Although these proteins have different size and domain composition, members of both families share a conserved DECH-box helicase domain. This helicase, also known as a duplex RNA activated ATPase, or DRA domain, plays an important role in viral RNA sensing. Crystallographic and electron microscopy studies of the RIG-I and Dicer DRA domains indicate a common structure and that similar conformational changes are induced by dsRNA binding. Genetic and biochemical studies on the function and regulation of DRAs reveal similarities, but also some differences, between viral RNA sensing mechanisms in nematodes, flies and mammals.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Paro S,Imler JL,Meignin Cdoi
10.1016/j.coi.2015.01.009subject
Has Abstractpub_date
2015-02-01 00:00:00pages
106-13eissn
0952-7915issn
1879-0372pii
S0952-7915(15)00010-2journal_volume
32pub_type
杂志文章,评审abstract::For many years IL-33 has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders. Interestingly, IL-33 has now emerged as a cytokine with a plethora of pleiotropic properties. Depending on the immune cells targeted by IL-33, it is reported to not only promote Th2 immunity, but also to...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2014.03.004
更新日期:2014-06-01 00:00:00
abstract::The presentation of antigenic peptides by MHC class I molecules plays a vital role in generating T cell responses against infection and cancer. Over the last two decades the central role of tapasin as a peptide editor that influences the loading and optimisation of peptides onto MHC class I molecules has been extensiv...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2017.04.008
更新日期:2017-06-01 00:00:00
abstract::The molecular repertoire for innate recognition of bacterial pathogens has expanded rapidly in the past decade. These immunosensors include Toll-like receptors and the more recently defined NOD-like receptors (NLRs): NODs, NALPs, NAIP and IPAF. Toll-like receptors signal from the cell surface or endosome upon ligand b...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2006.11.005
更新日期:2007-02-01 00:00:00
abstract::The classification of T helper (T(H)) cells in subsets has progressively expanded and more effector subsets, besides T(H)1 and T(H)2, have been documented. These include follicular helper T cells (T(FH)), and the more recent T(H)17, 'T(H)9', and 'T(H)22'. In addition, T(H) are no longer thought of as terminally commit...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2009.07.009
更新日期:2009-12-01 00:00:00
abstract::During the past couple of years there has been significant progress in our understanding of the development of different lineages of T cells within the thymus. Pathways, subpopulations and cellular dynamics are all becoming clearer. Signal transduction through primary and accessory receptors is also beginning to be un...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(91)90051-2
更新日期:1991-04-01 00:00:00
abstract::The identification and quantitation of peptides selected by class II MHC molecules during natural processing of proteins is of key importance in understanding the repertoire and distribution of T cells. The examination of peptides selected by class II MHC molecules has depended greatly on mass spectrometry, a powerful...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2005.11.002
更新日期:2006-02-01 00:00:00
abstract::Accessory molecules are required for microbial recognition by Toll-like receptor (TLR), subsequent signaling, and regulation of ensuing immune responses. Accessory molecules regulate TLRs on the cell surface (MD-2 and RP105), or in the endoplasmic reticulum (ER) (Unc93B, PRAT4A, and gp96). Other types of accessory mol...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2008.07.001
更新日期:2008-08-01 00:00:00
abstract::Allergen immunotherapy leads to tolerance through multiple mechanisms that include tolerogenic dendritic cells and T and B regulatory cells. These induced cellular populations produce mediators to skew the immune response to a tolerogenic milieu that, among others, results in IgG4 blocking antibodies formation and low...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2020.02.005
更新日期:2020-10-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(94)90079-5
更新日期:1994-10-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(99)80018-1
更新日期:1999-02-01 00:00:00
abstract::Recent studies have increased our understanding of the nature of autoimmune recognition and of the identity of autoantigens, at least in model systems. Knowledge of the autoantigens and the process of recognition is suggesting new therapies for autoimmune disease. ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(91)90071-8
更新日期:1991-02-01 00:00:00
abstract::MHC class I molecules present degradation products derived from intracellular proteins, whereas MHC class II molecules generally present peptides derived from extracellular or surface proteins. Recent insights into the cell biology of MHC class I and II molecules explain this difference. ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(93)90077-6
更新日期:1993-02-01 00:00:00
abstract::Antigen presenting cells (APCs) alert the immune system to attack by extracellular organisms; APCs achieve this via internalization, degradation, and display of antigenic fragments on the cell surface by MHC class II molecules. These class II molecules bind to an accessory protein, termed the invariant chain, that ens...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(01)00295-3
更新日期:2002-02-01 00:00:00
abstract::Phosphoinositide 3-kinase (PI3K) activation is essential for lymphocyte proliferation driven by receptors for antigen, costimulatory ligands and cytokines. The lipid products of PI3K contribute to the assembly of membrane-associated signaling complexes by promoting recruitment of selected proteins from the cytoplasm. ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2004.03.014
更新日期:2004-06-01 00:00:00
abstract::There are two competing theories to explain the mechanism(s) by which cytolytic T lymphocytes kill target cells: granule exocytosis of a pore-forming protein, and contact-induced internal disintegration. Accumulated evidence supports alternative pathways in lymphocytoxicity, possibly reflecting distinct effector funct...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(91)90031-u
更新日期:1991-06-01 00:00:00
abstract::Co-receptors have been shown to regulate the antigen-receptor signaling threshold for B cell responses by modulating the activation of signaling molecules that are essential for transmitting a signal through the antigen-receptor. Co-receptors appear to modulate the signaling threshold for B cell tolerance distinctly f...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(99)80041-7
更新日期:1999-06-01 00:00:00
abstract::Antimicrobials represent a broad class of chemicals with the intended purpose of eliminating or controlling the growth of harmful microorganisms. Exposure can occur occupationally or through the use or consumption of consumer products. The use of antimicrobial agents has been associated with an increased incidence of ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2019.05.003
更新日期:2019-10-01 00:00:00
abstract::Not surprisingly, most of the publications on enzyme immunoassays or latex agglutination tests in 1990 have been applications for specific antigens or antibodies. Nevertheless, a large number of studies of considerable interest to all users have been reported. In this short review, we have chosen to highlight investig...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(91)90057-8
更新日期:1991-04-01 00:00:00
abstract::Successful vaccination relies on driving the immune response towards high specificity, affinity and longevity. Germinal centers facilitate the evolution of antigen-specific B cells by iterative rounds of diversification, selection, and differentiation to memory and plasma cells. Experimental evidence points to B cell ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2017.03.007
更新日期:2017-04-01 00:00:00
abstract::Islets of Langerhans of all species harbor a small number of resident macrophages. These macrophages are found since birth, do not exchange with blood monocytes, and are maintained by a low level of replication. Under steady state conditions, the islet macrophages are in an activated state. Islet macrophages have an i...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2016.09.004
更新日期:2016-12-01 00:00:00
abstract::Dicer is a multifunctional protein that is essential across species for the generation of microRNAs, a function that is highly conserved across the plant and animal kingdoms. Intriguingly, Dicer exhibits antiviral functions in lower organisms including Drosophila melanogaster and Caenorhabditis elegans. Antiviral acti...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2013.10.015
更新日期:2014-02-01 00:00:00
abstract::A strong skeleton relies on adaptation to varying physical demands and on maintenance of the bone tissue in order to avoid accumulation of micro-damage. In bone, the purinergic P2X7 ion channel receptor is expressed on both cells of the stromal lineage such as the bone forming osteoblasts and the mechano-sensing osteo...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2018.03.016
更新日期:2018-06-01 00:00:00
abstract::It has recently become clear that several factors must coincide for the initiation of autoimmunity. At minimum, these involve a genetic predisposition, naive lymphocytes that can react with autoantigens and a precipitating event that leads to T and/or B cell activation. Inter-individual variations in these factors pro...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2004.09.002
更新日期:2004-12-01 00:00:00
abstract::Analysis of the T-cell receptor has revealed the molecular basis of antigen recognition by T cells specific for viral antigens. Studies using T-cell receptor transgenic mice have provided evidence for clonal deletion of virus-specific T cells in persistently infected hosts and for selection of T-cell-resistant virus v...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(91)90003-j
更新日期:1991-08-01 00:00:00
abstract::Gene expression variation is critical for the normal development and physiology of immune cells. Using cDNA microarrays, a systematic, genomic-scale view of gene expression in immune cells at many stages of differentiation and activation can be obtained. From the high vantagepoint provided by this technology, the gene...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(99)00078-3
更新日期:2000-04-01 00:00:00
abstract::The production of pathogenic autoantibodies in organ-specific autoimmune diseases is largely T cell dependent. For many of these diseases, the precise specificities and cytokine profiles of the T cells that respond to the corresponding autoantigens have now been identified. This knowledge has been exploited to treat s...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(00)00160-6
更新日期:2000-12-01 00:00:00
abstract::Much has been learned recently about the structure and function of 55 kDa bactericidal/permeability-increasing protein (BPI), a member of a genomically conserved lipid-interactive protein family. Analysis of BPI fragments and the crystal structure of human BPI have established that BPI consists of two functionally dis...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(98)80030-7
更新日期:1998-02-01 00:00:00
abstract::Dendritic cells are responsible for directing different types of T cell responses, from thymic negative selection to the generation of effector and memory cells and the induction of peripheral tolerance. Recent studies indicate that the dendritic cell lineage, the extent of recruitment into inflamed tissues and migrat...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(00)00218-1
更新日期:2001-06-01 00:00:00
abstract::Recent evidence indicates that genes required for antigen processing are present in the class II region of the MHC. Two new classes of MHC genes that may encode much of the machinery required in the class I (endogenous) antigen-processing pathway have been discovered. There is evidence that genes required in the class...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(92)90128-2
更新日期:1992-02-01 00:00:00
abstract::T cell responses are regulated by integrating positive and negative signals from costimulatory and inhibitory receptors. While the function of specific T cell costimulatory molecules during infections has been appreciated for some time, recent observations have now revealed a crucial role for inhibitory receptors in r...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2009.01.010
更新日期:2009-04-01 00:00:00