Present status on the genetic studies of asthma.

abstract：:Parasitic helminths continue to be a major cause of morbidity in human populations, particularly in the tropics and subtropics. The need for effective vaccines that minimize worm burdens, thus reducing associated pathology, is evident. With this goal in mind, an intense research effort is in progress to characterize i...

journal_title：Current opinion in immunology

authors： Wilson RA

更新日期：1993-08-01 00:00:00

abstract：:The presentation of antigenic peptides by MHC class I molecules plays a vital role in generating T cell responses against infection and cancer. Over the last two decades the central role of tapasin as a peptide editor that influences the loading and optimisation of peptides onto MHC class I molecules has been extensiv...

journal_title：Current opinion in immunology

authors： Neerincx A,Boyle LH

更新日期：2017-06-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) persists within the host in the presence of concomitant immunity by establishing a latent infection within sensory neurons. HSV-1 latency is widely viewed as a neuron-enforced quiescent state of the virus, in which a lack of viral protein synthesis prevents recognition of the infect...

journal_title：Current opinion in immunology

authors： Khanna KM,Lepisto AJ,Decman V,Hendricks RL

更新日期：2004-08-01 00:00:00

abstract：:Cancer results from a tumor cell intrinsic dysregulation of oncogenes, tumor suppressor and stability genes as well as from the avoidance of immunosurveillance. A complex network of cellular interactions allows one to mount cognate anti-tumor immune responses. Recently, discoveries have been made regarding the links b...

journal_title：Current opinion in immunology

authors： Ghiringhelli F,Apetoh L,Housseau F,Kroemer G,Zitvogel L

更新日期：2007-04-01 00:00:00

abstract：:Acute inflammatory responses are essential for pathogen control and tissue repair but can also cause severe collateral damage. Tight regulation of the response is required to minimize host injury, but in the face of chronic infections and age-associated immune dysregulation, inflammatory processes may exert multiple d...

journal_title：Current opinion in immunology

authors： Pawelec G,Goldeck D,Derhovanessian E

更新日期：2014-08-01 00:00:00

abstract：:The breaking of tolerance or unresponsiveness to self-antigens, involving the activation of autoreactive lymphocytes, is a critical event leading to autoimmune diseases. The precise mechanisms by which this can occur are mostly unknown. Viruses have been implicated in this process, among other etiological factors, suc...

journal_title：Current opinion in immunology

authors： von Herrath MG,Oldstone MB

更新日期：1996-12-01 00:00:00

abstract：:Sensing of RNA virus infection by the RIG-I-like receptors (RLRs) engages a complex signaling cascade that utilizes the mitochondrial antiviral signaling (MAVS) adapter protein to orchestrate the innate host response to pathogen, ultimately leading to the induction of antiviral and inflammatory responses mediated by t...

journal_title：Current opinion in immunology

authors： Belgnaoui SM,Paz S,Hiscott J

更新日期：2011-10-01 00:00:00

abstract：:Type I diabetes has resisted direct genetic analysis in humans but two excellent models of disease in rodents provide a more readily manipulated alternative for study. These rodent models are being used successfully to localize the genes that are involved in disease pathogenesis in preparation for positional cloning. ...

journal_title：Current opinion in immunology

authors： McDuffie M

更新日期：1998-12-01 00:00:00

abstract：:Perforin defects have been identified in humans with familial hematophagocytic lymphohistiocytosis. The pathology of these patients has dramatically illustrated an under-appreciated role for perforin in the regulation of T-cell responses in vivo, and experimental studies are shedding light on the mechanisms involved. ...

journal_title：Current opinion in immunology

authors： Catalfamo M,Henkart PA

更新日期：2003-10-01 00:00:00

abstract：:Hybrid resistance refers to the rejection of parental strain bone marrow cells by natural killer cells of mice that are F1 hybrids derived from two inbred parental strains. This pattern of rejection is not seen in solid organ transplants. Progress in understanding this exception to the laws of transplantation genetics...

journal_title：Current opinion in immunology

authors： Kumar V,George T,Yu YY,Liu J,Bennett M

更新日期：1997-02-01 00:00:00

abstract：:Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place sp...

journal_title：Current opinion in immunology

authors： Rubio-Ponce A,Hidalgo A,Ballesteros I

更新日期：2020-10-07 00:00:00

abstract：:The molecular repertoire for innate recognition of bacterial pathogens has expanded rapidly in the past decade. These immunosensors include Toll-like receptors and the more recently defined NOD-like receptors (NLRs): NODs, NALPs, NAIP and IPAF. Toll-like receptors signal from the cell surface or endosome upon ligand b...

journal_title：Current opinion in immunology

authors： Delbridge LM,O'Riordan MX

更新日期：2007-02-01 00:00:00

abstract：:There has been great progress in understanding the alloresponse and the process of immune recovery after stem cell transplantation. Here, we highlight ways in which transplant outcome is determined by unique immunological features of the early post-transplant period that modulate the growth and function of the grafted...

journal_title：Current opinion in immunology

authors： Barrett J

更新日期：2006-10-01 00:00:00

abstract：:Enteric microbial pathogens interact with the gut epithelium to establish infection. Recently, it has become clear that many microorganisms that colonize or traverse the intestinal mucosa do so via the specialized M cells. Recent work has shown that Shigella flexneri and Salmonella typhimurium specifically target M ce...

journal_title：Current opinion in immunology

authors： Jones B,Pascopella L,Falkow S

更新日期：1995-08-01 00:00:00

abstract：:Antiviral T-cell responses between individuals that have similar major histocompatibility complex molecules share similarities in epitope hierarchies and T-cell receptor variable gene usage (public specificities), yet the T-cell receptor amino acid sequences differ between individuals (private specificities). The sign...

journal_title：Current opinion in immunology

authors： Welsh RM

更新日期：2006-06-01 00:00:00

abstract：:Tolerance to the foetal 'allograft' has been extensively studied in the past few years, providing interesting new insights. In addition to a potential role for HLA-G, which has been widely discussed, there are hypotheses suggesting roles for several other molecules or cells: leukemia inhibitory factor and its receptor...

journal_title：Current opinion in immunology

authors： Thellin O,Coumans B,Zorzi W,Igout A,Heinen E

更新日期：2000-12-01 00:00:00

abstract：:Distinctions between tumor necrosis factor, TNF-alpha, and lymphotoxin, TNF-beta, have previously been based on the differences between their protein sequences, biological activity, and molecular regulation. In the past year, elucidation of the molecular nature of the two molecules and the interactions with common rec...

journal_title：Current opinion in immunology

authors： Ruddle NH

更新日期：1992-06-01 00:00:00

abstract：:The surface and lining tissues of our body are exposed to the external environment, and as such these epithelial tissues must form structural barriers able to defend against microbes, environmental toxins, and mechanical stress. Their cells are equipped to detect a diverse array of surface perturbations, and then laun...

journal_title：Current opinion in immunology

authors： Larsen SB,Cowley CJ,Fuchs E

更新日期：2020-02-01 00:00:00

abstract：:The origin of the complement system is much more ancient than that of adaptive immunity, which is only found in jawed vertebrates. Recently, complement components of the alternative and lectin pathways have been identified in jawless fishes, and even in some deuterostome invertebrates. The primitive complement system ...

journal_title：Current opinion in immunology

authors： Nonaka M

更新日期：2001-02-01 00:00:00

abstract：:Insects are particularly resistant to microorganisms. Their host-defense system relies on several innate reactions: upon injury, the immediate onset of two proteolytic cascades leading to localized blood clotting and to melanization, the latter process involving production of cytotoxic molecules (namely reactive oxyge...

journal_title：Current opinion in immunology

authors： Hoffmann JA

更新日期：1995-02-01 00:00:00

abstract：:Plants have the capacity to recognise and reject pathogens at various stages of their attempted colonisation of the plant. Non-specific rejection often arises as a consequence of the potential pathogen's attempt to breach the first lines of plant defence. Pathogens able to penetrate beyond this barrier of non-host res...

journal_title：Current opinion in immunology

authors： Jones DA,Takemoto D

更新日期：2004-02-01 00:00:00

abstract：:Peanuts are a frequent cause of food allergy and the most common cause of fatal food-induced anaphylaxis in the U.S. Advances during the past two years have promoted our understanding of peanut allergens and peanut allergy prevalence, etiology, diagnosis, and therapy. The advances highlighted in this review include ev...

journal_title：Current opinion in immunology

authors： Finkelman FD

更新日期：2010-12-01 00:00:00

abstract：:The mesenchymal microenvironment is increasingly recognized as a major player in immunity. Here we focus on mesenchymal cells located within or in proximity to the blood vessels wall, which include pericytes, adventitial fibroblasts and mesenchymal stromal cells. We discuss recent evidence that these cells play a role...

journal_title：Current opinion in immunology

authors： Benabid A,Peduto L

更新日期：2020-05-06 00:00:00

abstract：:Antigen presentation by CD80/CD86-positive 'professional APCs' induces T-cell activation, whereas antigen presentation in the absence of sufficient CD80/CD86 costimulation may induce a form of tolerance. Blocking CD80/CD86 constimulation inhibits autoimmune disease progression in a variety of animal models, but whethe...

journal_title：Current opinion in immunology

authors： Lu P,Wang YL,Linsley PS

更新日期：1997-12-01 00:00:00

abstract：:The emergence of new targeted therapies is rapidly improving the treatment of autoimmune disease. These drugs have been variably designed to deplete specific T and B cell subsets, interrupt receptor-ligand interactions, and inhibit the activity of inflammatory mediators relevant to immune function. Abatacept, a co-sti...

journal_title：Current opinion in immunology

authors： St Clair EW

更新日期：2009-12-01 00:00:00

abstract：:The extent of airway remodeling correlates with severity of asthma. Persistent airway hyperresponsiveness (AHR) is associated with airway remodeling, but not with inflammation. The increase in ASM mass is recognized as one of the most important factors related to AHR and to the severity of asthma. The infiltration of ...

journal_title：Current opinion in immunology

authors： Okayama Y,Ra C,Saito H

更新日期：2007-12-01 00:00:00

abstract：:V(D)J recombination not only comprises the molecular mechanism that insures diversity of the immune system but also constitutes a critical checkpoint in the developmental program of B and T lymphocytes. The analysis of human patients with severe combined immune deficiency (SCID) has enabled (and will enable in the fut...

journal_title：Current opinion in immunology

authors： de Villartay JP,Poinsignon C,de Chasseval R,Buck D,Le Guyader G,Villey I

更新日期：2003-10-01 00:00:00

abstract：:Recent research developments support the following views regarding antigen recognition in autoimmune demyelinating disease: there may be no single autoimmune target protein; diverse peptide self-determinants from multiple myelin proteins can be recognized; target determinant epitopes may differ among individuals; and ...

journal_title：Current opinion in immunology

authors： Tuohy VK,Fritz RB,Ben-Nun A

更新日期：1994-12-01 00:00:00

abstract：:Murine gamma-herpesvirus 68 (gammaHV68) infection is a new model for understanding how immunity and chronic gamma-herpesvirus infection inter-relate. gammaHV68 is closely related to the human Epstein-Barr virus and Kaposi's sarcoma herpesvirus and is associated with tumors, vasculitis of the great elastic arteries and...

journal_title：Current opinion in immunology

authors： Virgin HW,Speck SH

更新日期：1999-08-01 00:00:00

abstract：:Vaccines have been developed and deployed against several important bacterial pathogens of humans, including Neisseria meningitidis, Bordetella pertussis, Streptococcus pneumoniae and Mycobacterium tuberculosis. These vaccines are generally considered a successful public health measure and are effective at controlling...

journal_title：Current opinion in immunology

authors： Barnett TC,Lim JY,Soderholm AT,Rivera-Hernandez T,West NP,Walker MJ

更新日期：2015-10-01 00:00:00