Abstract：
:The presentation of antigenic peptides by MHC class I molecules plays a vital role in generating T cell responses against infection and cancer. Over the last two decades the central role of tapasin as a peptide editor that influences the loading and optimisation of peptides onto MHC class I molecules has been extensively characterised. Recently, it has become evident that the tapasin-related protein, TAPBPR, functions as a second peptide editor which influences the peptides displayed by MHC class I molecules. Here, we review the discovery of TAPBPR and current understanding of this novel protein in relation to its closest homologue tapasin.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Neerincx A,Boyle LHdoi
10.1016/j.coi.2017.04.008subject
Has Abstractpub_date
2017-06-01 00:00:00pages
97-102eissn
0952-7915issn
1879-0372pii
S0952-7915(16)30102-9journal_volume
46pub_type
杂志文章,评审abstract：:The syndrome termed 'Drug Reaction with Eosinophilia and Systemic Symptoms' (DRESS) is an unpredictable, life-threatening condition associated with adverse reactions to therapy. Although the etiology of DRESS is poorly understood, genetic susceptibility markers have been identified within the HLA complex and there are...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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abstract：:In normal hematopoiesis, differentiation and maturation of cell populations belonging to various lineages are tightly regulated by the interaction of many transcription factors. The relative numbers of different myeloid cells depends on their proliferative/apoptotic rate, while their identity relates to their recruitm...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(98)80225-2
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abstract：:Germinal centers (GCs) are well known for their important role in shaping the secondary B cell repertoire to generate antibodies capable of binding with high-affinity and specificity to foreign antigens. Somatic hypermutation of the Ig variable region genes in GC B cells represents a highly efficient mechanism for gen...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：2020-04-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：2007-04-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2013.10.015
更新日期：2014-02-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：1996-12-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2020.05.002
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：2000-12-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(02)00329-1
更新日期：2002-04-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2012.12.005
更新日期：2013-02-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2008.03.002
更新日期：2008-04-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2008.04.001
更新日期：2008-06-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(96)80081-1
更新日期：1996-10-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2005.09.013
更新日期：2005-12-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/S0952-7915(99)80078-8
更新日期：1999-08-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：2018-08-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：1998-06-01 00:00:00
abstract：:Three known lineages of antigen-presenting molecules restrict T-cell responses to microbial antigens: MHC class I and MHC encoded class I like molecules present peptides derived from the proteolysis of intracellular pathogens, MHC class ii molecules present peptides derived from the proteolysis of extracellular pathog...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：2008-10-01 00:00:00
abstract：:Immunotherapy of cancer with blockade of inhibitory immune checkpoints and adoptive cell therapies have led to impressive clinical responses in several cancers. However, with increasing utilization of these therapies, immune-related adverse events have emerged as a major obstacle. Herein I discuss recent insights into...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2019.08.004
更新日期：2019-12-01 00:00:00
abstract：:There are two competing theories to explain the mechanism(s) by which cytolytic T lymphocytes kill target cells: granule exocytosis of a pore-forming protein, and contact-induced internal disintegration. Accumulated evidence supports alternative pathways in lymphocytoxicity, possibly reflecting distinct effector funct...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(91)90031-u
更新日期：1991-06-01 00:00:00
