Long-lived plasma cells: a mechanism for maintaining persistent antibody production.

abstract：:A strong skeleton relies on adaptation to varying physical demands and on maintenance of the bone tissue in order to avoid accumulation of micro-damage. In bone, the purinergic P2X7 ion channel receptor is expressed on both cells of the stromal lineage such as the bone forming osteoblasts and the mechano-sensing osteo...

journal_title：Current opinion in immunology

authors： Jørgensen NR

更新日期：2018-06-01 00:00:00

abstract：:Monoclonal antibodies specific for defined peptide-MHC complexes are now being used to physically detect T-cell receptor ligands. These reagents have resulted in the identification of the cells that present antigen in lymphoid and non-lymphoid tissues after various forms of antigen administration. In addition, recent ...

journal_title：Current opinion in immunology

authors： Germain RN,Jenkins MK

更新日期：2004-02-01 00:00:00

abstract：:The past year has seen the publication of significant new findings on the regulation of CD23 expression, the precise interaction of CD23 with CD21 and its functional consequences. Moreover, new advances have been made in unravelling the biochemical network of events downstream from the triggering of CD23 in human B ce...

journal_title：Current opinion in immunology

authors： Bonnefoy JY,Lecoanet-Henchoz S,Aubry JP,Gauchat JF,Graber P

更新日期：1995-06-01 00:00:00

abstract：:Enteric microbial pathogens interact with the gut epithelium to establish infection. Recently, it has become clear that many microorganisms that colonize or traverse the intestinal mucosa do so via the specialized M cells. Recent work has shown that Shigella flexneri and Salmonella typhimurium specifically target M ce...

journal_title：Current opinion in immunology

authors： Jones B,Pascopella L,Falkow S

更新日期：1995-08-01 00:00:00

abstract：:Recent findings indicate that activated T lymphocytes, showing restricted T-cell receptor repertoire and a Th1-like profile of cytokine production, are responsible for macrophage activation and release of inflammatory cytokines, toxic oxygen metabolites and nitric oxide, which initiate and maintain the transmural inte...

journal_title：Current opinion in immunology

authors： Romagnani P,Annunziato F,Baccari MC,Parronchi P

更新日期：1997-12-01 00:00:00

abstract：:It has recently become clear that several factors must coincide for the initiation of autoimmunity. At minimum, these involve a genetic predisposition, naive lymphocytes that can react with autoantigens and a precipitating event that leads to T and/or B cell activation. Inter-individual variations in these factors pro...

journal_title：Current opinion in immunology

authors： Christen U,von Herrath MG

更新日期：2004-12-01 00:00:00

abstract：:The presentation of antigenic peptides by MHC class I molecules plays a vital role in generating T cell responses against infection and cancer. Over the last two decades the central role of tapasin as a peptide editor that influences the loading and optimisation of peptides onto MHC class I molecules has been extensiv...

journal_title：Current opinion in immunology

authors： Neerincx A,Boyle LH

更新日期：2017-06-01 00:00:00

abstract：:Herpes zoster is common in older and immune suppressed persons due to diminished VZV-specific cellular immunity. A recombinant herpes zoster vaccine (RZV) consisting of a single VZV glycoprotein and an adjuvant system stimulates robust and persistent VZV-specific antibody and CD4+ T cell responses in these high-risk p...

journal_title：Current opinion in immunology

authors： Heineman TC,Cunningham A,Levin M

更新日期：2019-08-01 00:00:00

abstract：:Germinal centers (GCs) are well known for their important role in shaping the secondary B cell repertoire to generate antibodies capable of binding with high-affinity and specificity to foreign antigens. Somatic hypermutation of the Ig variable region genes in GC B cells represents a highly efficient mechanism for gen...

journal_title：Current opinion in immunology

authors： Lau AW,Brink R

更新日期：2020-04-01 00:00:00

abstract：:The rise in IgE-mediated food allergy in recent times is the likely result of gene-environment interactions mediated via epigenetic pathways. As epigenetic modifications, including DNA methylation, are at the interface between the environment and the genome, they may be ideal biomarkers of modifiable disease pathways....

journal_title：Current opinion in immunology

authors： Martino DJ,Saffery R,Allen KJ,Prescott SL

更新日期：2016-10-01 00:00:00

abstract：:The molecular repertoire for innate recognition of bacterial pathogens has expanded rapidly in the past decade. These immunosensors include Toll-like receptors and the more recently defined NOD-like receptors (NLRs): NODs, NALPs, NAIP and IPAF. Toll-like receptors signal from the cell surface or endosome upon ligand b...

journal_title：Current opinion in immunology

authors： Delbridge LM,O'Riordan MX

更新日期：2007-02-01 00:00:00

abstract：:Consolidating the information that we have on pharmacogenetics and on cytokine genetics to produce patient-oriented individualized drug regimens is an important challenge in transplantation medicine. Using a multi-variant approach based on genetic profile and other relevant clinical factors a score system may be devel...

journal_title：Current opinion in immunology

authors： Girnita DM,Burckart G,Zeevi A

更新日期：2008-10-01 00:00:00

abstract：:Insects are particularly resistant to microorganisms. Their host-defense system relies on several innate reactions: upon injury, the immediate onset of two proteolytic cascades leading to localized blood clotting and to melanization, the latter process involving production of cytotoxic molecules (namely reactive oxyge...

journal_title：Current opinion in immunology

authors： Hoffmann JA

更新日期：1995-02-01 00:00:00

abstract：:Cellular entry of HIV-1 is mediated by interaction with CD4 and chemokine receptors that serve as entry coreceptors. The immune response against HIV-1 is regulated by genes of the HLA locus. Genetic polymorphisms in these genes have recently been associated with effects on HIV-1 pathogenesis. The history and implicati...

journal_title：Current opinion in immunology

authors： Michael NL

更新日期：1999-08-01 00:00:00

abstract：:Peanuts are a frequent cause of food allergy and the most common cause of fatal food-induced anaphylaxis in the U.S. Advances during the past two years have promoted our understanding of peanut allergens and peanut allergy prevalence, etiology, diagnosis, and therapy. The advances highlighted in this review include ev...

journal_title：Current opinion in immunology

authors： Finkelman FD

更新日期：2010-12-01 00:00:00

abstract：:Various new aspects of antigen processing have been uncovered through the study of tumor antigens. One of these is the production of antigenic peptides by splicing of two distinct peptide fragments. In one of the two cases reported, the proteasome was found to be responsible for splicing. The presentation of another p...

journal_title：Current opinion in immunology

authors： van der Bruggen P,Van den Eynde BJ

更新日期：2006-02-01 00:00:00

abstract：:Precursor B cells assemble a diverse repertoire of immunoglobulin (Ig) genes by the process of V(D)J recombination. Assembly of IgH genes is regulated in a tissue- and stage-specific manner via the activation and then the inactivation of distinct regions within the one megabase IgH locus. Recent studies have shown tha...

journal_title：Current opinion in immunology

authors： Sen R,Oltz E

更新日期：2006-06-01 00:00:00

abstract：:Dicer is a multifunctional protein that is essential across species for the generation of microRNAs, a function that is highly conserved across the plant and animal kingdoms. Intriguingly, Dicer exhibits antiviral functions in lower organisms including Drosophila melanogaster and Caenorhabditis elegans. Antiviral acti...

journal_title：Current opinion in immunology

authors： MacKay CR,Wang JP,Kurt-Jones EA

更新日期：2014-02-01 00:00:00

abstract：:The usefulness of molecular diagnosis is now well established for genetically determined recurrent fevers. In familial Mediterranean fever, the severity of the disease and the risk of renal amyloidosis are correlated with mutations in MEFV, and the serum amyloid-associated protein (SAA)1 alpha/alpha allele is a modify...

journal_title：Current opinion in immunology

authors： Delpech M,Grateau G

更新日期：2001-10-01 00:00:00

abstract：:The extent of airway remodeling correlates with severity of asthma. Persistent airway hyperresponsiveness (AHR) is associated with airway remodeling, but not with inflammation. The increase in ASM mass is recognized as one of the most important factors related to AHR and to the severity of asthma. The infiltration of ...

journal_title：Current opinion in immunology

authors： Okayama Y,Ra C,Saito H

更新日期：2007-12-01 00:00:00

abstract：:Cytokines have been presumed to play an important role during T-cell development, but until recently formal proof has been missing. Most cytokine-knockout mice show apparently normal intrathymic T-cell development. The exception to this is IL-7, as both IL-7 and IL-7R alpha knockout mice show abnormally low thymic cel...

journal_title：Current opinion in immunology

authors： Zlotnik A,Moore TA

更新日期：1995-04-01 00:00:00

abstract：:V(D)J recombination can be separated into two basic operations: DNA cleavage and joining of broken ends. Our understanding of both reactions has increased substantially in the past year. Major advances include the development of a cell-free system capable of cleavage and the identification of several proteins involved...

journal_title：Current opinion in immunology

authors： Bogue M,Roth DB

更新日期：1996-04-01 00:00:00

abstract：:Infection with helminths has been associated with lower rates of asthma and other allergic diseases. This has been attributed, in part, to the ability of helminths to induce regulatory T cells that suppress inappropriate immune responses to allergens. Recent compelling evidence suggests that helminths may promote regu...

journal_title：Current opinion in immunology

authors： Logan J,Navarro S,Loukas A,Giacomin P

更新日期：2018-10-01 00:00:00

abstract：:The invariant chain (Ii) has been shown to play a critical role in the assembly, intracellular transport and function of MHC class II molecules. Recent studies suggest that these distinct activities can in many cases be attributed to distinct isoforms of Ii or to specific regions within it. Thus, regulation of Ii synt...

journal_title：Current opinion in immunology

authors： Sant AJ,Miller J

更新日期：1994-02-01 00:00:00

abstract：:CD8 T cell differentiation is a tightly regulated process generating effector and memory T cells over the course of acute infections. In cancer and chronic infection, this differentiation program is derailed, and antigen-specific CD8 T cells differentiate to a hyporesponsive state generally referred to as T cell exhau...

journal_title：Current opinion in immunology

authors： Philip M,Schietinger A

更新日期：2019-06-01 00:00:00

abstract：:The discovery of defined tumor antigens and their application in therapeutic cancer vaccines has not yet resulted in a successful therapy for cancer patients. Recent data suggest that this might be because most current clinical immunotherapeutic strategies rely on a tolerized tumor-reactive T-cell repertoire, resultin...

journal_title：Current opinion in immunology

authors： Overwijk WW

更新日期：2005-04-01 00:00:00

abstract：:The hygiene hypothesis was initially formulated to explain the steep increase in the prevalence of allergies in Western societies observed over the past few decades. It proposes that the microbial environment interfaces with the innate immune system and modulates its ability to impart instructions to adaptive immune r...

journal_title：Current opinion in immunology

authors： Vercelli D

更新日期：2006-12-01 00:00:00

abstract：:The discovery of the CD1 antigen-presenting system reveals that T cells survey the lipid content of target cells via T-cell receptor (TCR) contact with CD1 bound to lipids, glycolipids and small molecules. Recently, CD1 proteins have been found to present mycobacterial lipopeptides that are involved in scavenging iron...

journal_title：Current opinion in immunology

authors： Van Rhijn I,Zajonc DM,Wilson IA,Moody DB

更新日期：2005-06-01 00:00:00

abstract：:The transplantation of organs between individuals of disparate species is being considered as a potential solution to a serious shortage of donor organs for clinical transplantation. We summarize recent papers concerning the immunologic barrier to xenotransplantation, the pathogenesis of hyperacute rejection and repor...

journal_title：Current opinion in immunology

authors： Platt JL,Bach FH

更新日期：1991-10-01 00:00:00

abstract：:Somatic mutations in the genome represent one of the major drivers of malignancy. However, non-synonymous mutations are also a source of mutated peptides that are presented by HLA molecules to induce protective CD4 and CD8 T cell responses. Consistent with this notion, the mutation burden of a tumor is correlated with...

journal_title：Current opinion in immunology

authors： Schumacher TN,Hacohen N

更新日期：2016-08-01 00:00:00