Abstract:
:CD8 T cell differentiation is a tightly regulated process generating effector and memory T cells over the course of acute infections. In cancer and chronic infection, this differentiation program is derailed, and antigen-specific CD8 T cells differentiate to a hyporesponsive state generally referred to as T cell exhaustion. Here, we review recent findings on heterogeneity of tumor-specific T cells and exhausted T cells during chronic infections, discussing distinct differentiation state dynamics, fate choices, and functional states. Delineating the regulatory mechanisms defining distinct T cell states and determining the requirements for therapeutic reprogramming of these states will provide needed insights for the design of effective immunotherapies for the treatment of cancer and chronic infections.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Philip M,Schietinger Adoi
10.1016/j.coi.2019.04.014subject
Has Abstractpub_date
2019-06-01 00:00:00pages
98-103eissn
0952-7915issn
1879-0372pii
S0952-7915(19)30034-2journal_volume
58pub_type
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