Abstract：
:Germinal centers (GCs) are well known for their important role in shaping the secondary B cell repertoire to generate antibodies capable of binding with high-affinity and specificity to foreign antigens. Somatic hypermutation of the Ig variable region genes in GC B cells represents a highly efficient mechanism for generating new antibody variants with increased antigen affinity. To be effective, however, this process needs to be intimately linked with equally efficient processes that positively select high-affinity clones for perpetuation in the GC and, ultimately, for differentiation into plasma cell and memory B cell effector populations. Just as important is the need for mechanisms of negative selection that remove GC B cell clones with unwanted specificities, particularly those that have gained reactivity with self-components. Here, we discuss recent advances in our understanding of the various selective processes that occur within the GC and identify the major questions in this field that remain to be answered.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Lau AW,Brink Rdoi
10.1016/j.coi.2019.11.001subject
Has Abstractpub_date
2020-04-01 00:00:00pages
29-34eissn
0952-7915issn
1879-0372pii
S0952-7915(19)30080-9journal_volume
63pub_type
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