Abstract:
:Protective and pathogenic immune responses were initially thought to be determined by the differentiation of naïve T cells into Th1 and Th2 effector subsets and the immunosuppressive activity of thymic-derived regulatory T cells. It is now clear that naïve T cells can also differentiate into 'induced' regulatory T cells or inflammatory T cells that secrete IL-17. These divergent T-cell subsets have opposing functions in imparting inflammation or tolerance, yet both developmental programs are controlled by the pluripotent cytokine transforming growth factor beta and the transcription factor NFAT. Recent findings have begun to shed light on the mechanisms by which TGF-beta and NFAT integrate multiple signaling inputs to determine the direction of naïve T-cell differentiation.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Sundrud MS,Rao Adoi
10.1016/j.coi.2007.04.014subject
Has Abstractpub_date
2007-06-01 00:00:00pages
287-93issue
3eissn
0952-7915issn
1879-0372pii
S0952-7915(07)00066-0journal_volume
19pub_type
杂志文章,评审abstract::Although autoantigen-induced negative selection plays an important role in shaping the mature B-cell repertoire, studies in recent years have suggested that differentiation into any of the three mature B-cell subsets (marginal zone B cells, follicular B cells and B-1 B cells) is not a passive product of autoreactive B...
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journal_title:Current opinion in immunology
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