Abstract：
:The identification of human papillomavirus as the etiological factor for cervical cancer provides an opportunity to treat these malignancies by vaccination. Although therapeutic vaccination against viral oncogenes regularly induces a specific T cell response, clinical effectivity remains low. Three factors are particularly important for clinical outcome: the balance between cytotoxic T cells and regulatory immune subsets, the balance between cytotoxic T cells and tumor cells and finally the killing efficiency of cytotoxic T cells within the tumor. To improve these three factors, therapeutic vaccination is combined with other treatments. Here, we review those studies that are based on understanding the inhibitory mechanisms that prevent unleashing the full power of therapeutic vaccine-induced T cells and utilize combinatorial interventions based on these insights.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
van der Sluis TC,van der Burg SH,Arens R,Melief CJdoi
10.1016/j.coi.2015.05.002subject
Has Abstractpub_date
2015-08-01 00:00:00pages
9-14eissn
0952-7915issn
1879-0372pii
S0952-7915(15)00063-1journal_volume
35pub_type
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