Abstract：
:The commensal bacteria normally resident in the gastrointestinal tract represent an enormous pool of foreign antigen within the body. Although mechanical barriers limit entry of bacteria into the host, recent data suggest that T cells routinely interact with commensal bacteria using both antigen-specific and non-specific receptors. Depending on the bacterial species, either regulatory or effector T cell responses can be generated. For example, segmented filamentous bacteria (SFB) favor effector Th17 responses whereas Bacteroides fragilis and certain Clostridium species favor Foxp3+ regulatory T (Treg) cell responses. Thus, in contrast with the notion that only tolerogenic responses are required to self, gut homeostasis may require both tolerance and immunity to various constituents of the commensal microbiota.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Nutsch KM,Hsieh CSdoi
10.1016/j.coi.2012.04.009subject
Has Abstractpub_date
2012-08-01 00:00:00pages
385-91issue
4eissn
0952-7915issn
1879-0372pii
S0952-7915(12)00069-6journal_volume
24pub_type
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