Chemokines and lymphocyte biology.

abstract：:T-lymphocyte activation is initiated by the interaction of the alpha beta TCR with a complex consisting of a class I or class II MHC-encoded molecule and an antigenic peptide, displayed on the surface of an antigen-presenting cell. Real-time binding measurements using surface plasmon resonance have revealed kinetic an...

journal_title：Current opinion in immunology

authors： Margulies DH,Plaksin D,Khilko SN,Jelonek MT

更新日期：1996-04-01 00:00:00

abstract：:The Toll-like receptors (TLRs) of the innate immune system detect host invasion by pathogens and initiate immune responses. All of the TLRs use the adaptor MyD88 to transduce a signal; however, two newly identified signaling molecules, TIRAP and TRIF, interact with a subset of the TLRs, suggesting a signaling specific...

journal_title：Current opinion in immunology

authors： Kopp E,Medzhitov R

更新日期：2003-08-01 00:00:00

abstract：:Significant advances in research on the immunopathogenesis of leishmaniasis include the discovery of novel putative evasion and survival strategies of Leishmania parasites, a more detailed understanding of the function and regulation of interleukin-12, definition of molecules involved in cognate interaction between ma...

journal_title：Current opinion in immunology

authors： Bogdan C,Gessner A,Solbach W,Röllinghoff M

更新日期：1996-08-01 00:00:00

abstract：:Triggers involved in the development of an autoimmune disease, and those that are part of determining its level of severity, are a major focus of current investigative efforts. However, factors that increase the risk to disease may not be similar to those that determine its severity or its pace of progression. The ary...

journal_title：Current opinion in immunology

authors： Veldhoen M,Duarte JH

更新日期：2010-12-01 00:00:00

abstract：:Rational selection of individual adjuvants can often be made on the basis of innate molecular interactions of the foreign molecules with pattern recognition receptors such as Toll-like receptors. For example, monophosphoryl lipid A, a family of endotoxic TLR4 agonist molecules from bacteria, has recently been formulat...

journal_title：Current opinion in immunology

authors： Alving CR,Peachman KK,Rao M,Reed SG

更新日期：2012-06-01 00:00:00

abstract：:Antigen presentation by CD80/CD86-positive 'professional APCs' induces T-cell activation, whereas antigen presentation in the absence of sufficient CD80/CD86 costimulation may induce a form of tolerance. Blocking CD80/CD86 constimulation inhibits autoimmune disease progression in a variety of animal models, but whethe...

journal_title：Current opinion in immunology

authors： Lu P,Wang YL,Linsley PS

更新日期：1997-12-01 00:00:00

abstract：:The canonical NF-κB pathway instructs the expression of inflammatory genes by the RelA:p50 transcription factor in response to diverse cell-activating stimuli. However, this mainstay RelA:p50 transcriptional output must also be curated so as to provide for stimulus-type-specific and cell-type-specific inflammatory res...

journal_title：Current opinion in immunology

authors： Chawla M,Roy P,Basak S

更新日期：2020-09-05 00:00:00

abstract：:IL-17-producing T cells have recently been classified as a new effector T-cell subset, termed Th17, which is distinct from Th1, Th2 and Treg subsets. There has been much progress in the past year, leading to identification of the molecular mechanisms that drive differentiation of Th17 T cells. This has helped to clari...

journal_title：Current opinion in immunology

authors： Stockinger B,Veldhoen M

更新日期：2007-06-01 00:00:00

abstract：:The discovery of novel immune receptors has led to a recent renaissance of research into the innate immune system, following decades of intense research of the adaptive immune system. Of particular interest has been the discovery of the natural killer (NK) cell receptors which, depending on type, interact with classic...

journal_title：Current opinion in immunology

authors： Sambrook JG,Beck S

更新日期：2007-10-01 00:00:00

abstract：:The hygiene hypothesis was initially formulated to explain the steep increase in the prevalence of allergies in Western societies observed over the past few decades. It proposes that the microbial environment interfaces with the innate immune system and modulates its ability to impart instructions to adaptive immune r...

journal_title：Current opinion in immunology

authors： Vercelli D

更新日期：2006-12-01 00:00:00

abstract：:The past year has seen the publication of significant new findings on the regulation of CD23 expression, the precise interaction of CD23 with CD21 and its functional consequences. Moreover, new advances have been made in unravelling the biochemical network of events downstream from the triggering of CD23 in human B ce...

journal_title：Current opinion in immunology

authors： Bonnefoy JY,Lecoanet-Henchoz S,Aubry JP,Gauchat JF,Graber P

更新日期：1995-06-01 00:00:00

abstract：:Multiple sclerosis (MS) afflicts about 2.5 million people globally and poses a major personal and socioeconomic burden. The recognition of MS as an inflammatory disease, characterized by infiltration of immune cells into the central nervous system, has spurred research into the autoimmune etiology of the condition and...

journal_title：Current opinion in immunology

authors： Dendrou CA,Fugger L

更新日期：2017-12-01 00:00:00

abstract：:Acute inflammatory responses are essential for pathogen control and tissue repair but can also cause severe collateral damage. Tight regulation of the response is required to minimize host injury, but in the face of chronic infections and age-associated immune dysregulation, inflammatory processes may exert multiple d...

journal_title：Current opinion in immunology

authors： Pawelec G,Goldeck D,Derhovanessian E

更新日期：2014-08-01 00:00:00

abstract：:Parkinson's disease (PD) is caused by the progressive loss of dopaminergic neurons and afflicts millions of people world-wide. The current treatments address only the late motor symptoms, with no cure or preventive therapeutic approaches. The contribution of dysfunctional immune mechanisms in PD has been clearly estab...

journal_title：Current opinion in immunology

authors： Fahmy AM,Boulais J,Desjardins M,Matheoud D

更新日期：2019-06-01 00:00:00

abstract：:Antigens from a wide variety of pathogens have been identified as members of conserved heat-shock protein families, sharing upwards of 50% amino acid identity with corresponding host-cell proteins. Analysis of the responses to these conserved antigens may provide insights into regulation of the immune system during in...

journal_title：Current opinion in immunology

authors： Young DB

更新日期：1992-08-01 00:00:00

abstract：:Tumors of diverse origin have recently been shown to express CD95 ligand and to induce apoptosis in CD95-expressing targets in vitro; however, in vivo, enhanced tumor growth and rejection have both been observed as a consequence of either immunosuppressive or proinflammatory functions of CD95 ligand. The final in vivo...

journal_title：Current opinion in immunology

authors： Walker PR,Saas P,Dietrich PY

更新日期：1998-10-01 00:00:00

abstract：:The breaking of tolerance or unresponsiveness to self-antigens, involving the activation of autoreactive lymphocytes, is a critical event leading to autoimmune diseases. The precise mechanisms by which this can occur are mostly unknown. Viruses have been implicated in this process, among other etiological factors, suc...

journal_title：Current opinion in immunology

authors： von Herrath MG,Oldstone MB

更新日期：1996-12-01 00:00:00

abstract：:Three known lineages of antigen-presenting molecules restrict T-cell responses to microbial antigens: MHC class I and MHC encoded class I like molecules present peptides derived from the proteolysis of intracellular pathogens, MHC class ii molecules present peptides derived from the proteolysis of extracellular pathog...

journal_title：Current opinion in immunology

authors： Melián A,Beckman EM,Porcelli SA,Brenner MB

更新日期：1996-02-01 00:00:00

abstract：:The innate immune system is comprised of a sophisticated network of recognition and effector molecules that act together to protect the host in the first minutes or hours of exposure to an infectious challenge. The mannose-binding lectin (MBL) is an evolutionary conserved circulating host defense protein that acts as ...

journal_title：Current opinion in immunology

authors： Takahashi K,Ip WE,Michelow IC,Ezekowitz RA

更新日期：2006-02-01 00:00:00

abstract：:Graft versus host disease (GVHD) remains the major obstacle to the application of bone marrow transplantation across HLA barriers. Recent advances in our understanding of GVHD pathophysiology have resulted in the evaluation in animal models and in clinical trials of some novel approaches to avoiding and treating GVHD....

journal_title：Current opinion in immunology

authors： Sykes M

更新日期：1993-10-01 00:00:00

abstract：:Protective and pathogenic immune responses were initially thought to be determined by the differentiation of naïve T cells into Th1 and Th2 effector subsets and the immunosuppressive activity of thymic-derived regulatory T cells. It is now clear that naïve T cells can also differentiate into 'induced' regulatory T cel...

journal_title：Current opinion in immunology

authors： Sundrud MS,Rao A

更新日期：2007-06-01 00:00:00

abstract：:V(D)J recombination can be separated into two basic operations: DNA cleavage and joining of broken ends. Our understanding of both reactions has increased substantially in the past year. Major advances include the development of a cell-free system capable of cleavage and the identification of several proteins involved...

journal_title：Current opinion in immunology

authors： Bogue M,Roth DB

更新日期：1996-04-01 00:00:00

abstract：:The rise in IgE-mediated food allergy in recent times is the likely result of gene-environment interactions mediated via epigenetic pathways. As epigenetic modifications, including DNA methylation, are at the interface between the environment and the genome, they may be ideal biomarkers of modifiable disease pathways....

journal_title：Current opinion in immunology

authors： Martino DJ,Saffery R,Allen KJ,Prescott SL

更新日期：2016-10-01 00:00:00

abstract：:Conceptually, a universal influenza vaccine should elicit broadly protective antibody responses targeting highly conserved epitope(s) shared by various virus strains. Strategically directing antibody immunity to the conserved hemagglutinin stalk has recently emerged as a promising approach that is substantiated by the...

journal_title：Current opinion in immunology

authors： Zhao C,Xu J

更新日期：2018-08-01 00:00:00

abstract：:Individuals are exposed to influenza viruses throughout their lifetime. Accumulating evidence shows the first viruses an individual is exposed to leaves an imprint on the antibody response induced by subsequent drifted and novel influenza viral exposures. Imprinted humoral immunity against influenza viruses relies on ...

journal_title：Current opinion in immunology

authors： Guthmiller JJ,Wilson PC

更新日期：2018-08-01 00:00:00

abstract：:Killer Ig-like receptors (KIRs) are surface inhibitory receptors specific for allelic forms of human leukocyte antigen (HLA) class I molecules, which are expressed by natural killer (NK) cells and a subset of T lymphocytes. Upon engagement with HLA class I molecules, KIRs block NK cell activation and function. Cells l...

journal_title：Current opinion in immunology

authors： Moretta L,Moretta A

更新日期：2004-10-01 00:00:00

abstract：:The recent discovery of PTPN22 as a novel susceptibility gene in human type 1 diabetes and continued progress in defining genes in animal models of the disease mark a fruitful period in the field of type 1 diabetes genetics. In addition, the similarities of the genetic and functional aspects across species have been s...

journal_title：Current opinion in immunology

authors： Maier LM,Wicker LS

更新日期：2005-12-01 00:00:00

abstract：:In normal hematopoiesis, differentiation and maturation of cell populations belonging to various lineages are tightly regulated by the interaction of many transcription factors. The relative numbers of different myeloid cells depends on their proliferative/apoptotic rate, while their identity relates to their recruitm...

journal_title：Current opinion in immunology

authors： Sonda N,Chioda M,Zilio S,Simonato F,Bronte V

更新日期：2011-04-01 00:00:00

abstract：:The past year has seen the discovery of new isolates which do not readily fit into the established categories HIV-1, HIV-2 and SIV, as well as the availability of new assays including the use of the polymerase chain reaction. New combination enzyme-linked immunosorbent assays can detect viruses from two or more groups...

journal_title：Current opinion in immunology

authors： Dalgleish AG

更新日期：1991-08-01 00:00:00

abstract：:A diverse B cell repertoire is essential for an effective immune response. Not only to provide a variety of antibodies to recognise the multiplicity of likely pathogen challenge, but also because B cells are important regulators of the immune response. In addition to their excellent capabilities as antigen presenting ...

journal_title：Current opinion in immunology

authors： Dunn-Walters DK,Ademokun AA

更新日期：2010-08-01 00:00:00