Abstract:
:Parkinson's disease (PD) is caused by the progressive loss of dopaminergic neurons and afflicts millions of people world-wide. The current treatments address only the late motor symptoms, with no cure or preventive therapeutic approaches. The contribution of dysfunctional immune mechanisms in PD has been clearly established, with an emphasis on neuroinflammation and microglial cell activation. Recent studies have widened the involvement of the immune system in this disease by clearly showing the engagement of adaptive immunity and antigen presentation processes, directly regulated by PD-related proteins, raising the question whether PD is an autoimmune disease. The contribution of autoimmune mechanisms in PD opens novel avenues for the development of preventive therapeutic approaches.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Fahmy AM,Boulais J,Desjardins M,Matheoud Ddoi
10.1016/j.coi.2019.02.004subject
Has Abstractpub_date
2019-06-01 00:00:00pages
31-37eissn
0952-7915issn
1879-0372pii
S0952-7915(19)30006-8journal_volume
58pub_type
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