Oncolytic viruses and immunity.

abstract：:The hypothesis that protein kinase C (PKC)-theta; plays an important role in T-lymphocyte activation, as indicated by numerous studies in cell lines, was recently confirmed in mice deficient in the expression of this enzyme. In response to TCR stimulation, peripheral T cells lacking PKC-theta; failed to activate NF-ka...

journal_title：Current opinion in immunology

authors： Arendt CW,Albrecht B,Soos TJ,Littman DR

更新日期：2002-06-01 00:00:00

abstract：:Immunity to intracellular pathogens and cancer relies on the generation of robust CD8(+) T cell effector responses as well as the establishment of immunological memory. During a primary immune response CD8(+) T cells experience diverse extracellular environmental cues and cell-cell interactions that trigger downstream...

journal_title：Current opinion in immunology

authors： Thaventhiran JE,Fearon DT,Gattinoni L

更新日期：2013-06-01 00:00:00

abstract：:Three known lineages of antigen-presenting molecules restrict T-cell responses to microbial antigens: MHC class I and MHC encoded class I like molecules present peptides derived from the proteolysis of intracellular pathogens, MHC class ii molecules present peptides derived from the proteolysis of extracellular pathog...

journal_title：Current opinion in immunology

authors： Melián A,Beckman EM,Porcelli SA,Brenner MB

更新日期：1996-02-01 00:00:00

abstract：:Within a few years of the discovery of Toll-like receptors (TLRs) and their role in innate immunity, viral and bacterial proteins were recognized to antagonize TLR signal transduction. Since then, as TLR signaling networks were unraveled, microbial systems have been discovered that target nearly every component within...

journal_title：Current opinion in immunology

authors： Rosadini CV,Kagan JC

更新日期：2015-02-01 00:00:00

abstract：:Sensing of RNA virus infection by the RIG-I-like receptors (RLRs) engages a complex signaling cascade that utilizes the mitochondrial antiviral signaling (MAVS) adapter protein to orchestrate the innate host response to pathogen, ultimately leading to the induction of antiviral and inflammatory responses mediated by t...

journal_title：Current opinion in immunology

authors： Belgnaoui SM,Paz S,Hiscott J

更新日期：2011-10-01 00:00:00

abstract：:The molecular repertoire for innate recognition of bacterial pathogens has expanded rapidly in the past decade. These immunosensors include Toll-like receptors and the more recently defined NOD-like receptors (NLRs): NODs, NALPs, NAIP and IPAF. Toll-like receptors signal from the cell surface or endosome upon ligand b...

journal_title：Current opinion in immunology

authors： Delbridge LM,O'Riordan MX

更新日期：2007-02-01 00:00:00

abstract：:Islets of Langerhans of all species harbor a small number of resident macrophages. These macrophages are found since birth, do not exchange with blood monocytes, and are maintained by a low level of replication. Under steady state conditions, the islet macrophages are in an activated state. Islet macrophages have an i...

journal_title：Current opinion in immunology

authors： Carrero JA,Ferris ST,Unanue ER

更新日期：2016-12-01 00:00:00

abstract：:Various new aspects of antigen processing have been uncovered through the study of tumor antigens. One of these is the production of antigenic peptides by splicing of two distinct peptide fragments. In one of the two cases reported, the proteasome was found to be responsible for splicing. The presentation of another p...

journal_title：Current opinion in immunology

authors： van der Bruggen P,Van den Eynde BJ

更新日期：2006-02-01 00:00:00

abstract：:The adhesive phenotypes expressed by Plasmodium-falciparum-infected erythrocytes were previously thought simply to permit sequestration of parasites in the peripheral circulation. Recent work has illuminated how falciparum-infected erythrocytes may modulate the function of monocytes, macrophages and myeloid dendritic ...

journal_title：Current opinion in immunology

authors： Urban BC,Roberts DJ

更新日期：2002-08-01 00:00:00

abstract：:Peptide-MHC interactions govern the fate of T cells in the thymus and the peripheral T cell repertoire. Recent progress has involved investigating how different peptides influence T cell selection and mature T cell function and the subsequent implications for tolerance and autoimmunity. ...

journal_title：Current opinion in immunology

authors： Ohashi PS

更新日期：1996-12-01 00:00:00

abstract：:B-cell antigen receptor (BCR) signals are crucial for initiation of humoral immune responses and must be actively modulated and/or terminated in preparation for receipt of subsequent cues for progression. BCR signaling is also actively inhibited in autoreactive cells in which unresponsiveness is maintained by anergy. ...

journal_title：Current opinion in immunology

authors： Gauld SB,Merrell KT,Cambier JC

更新日期：2006-06-01 00:00:00

abstract：:Antimicrobials represent a broad class of chemicals with the intended purpose of eliminating or controlling the growth of harmful microorganisms. Exposure can occur occupationally or through the use or consumption of consumer products. The use of antimicrobial agents has been associated with an increased incidence of ...

journal_title：Current opinion in immunology

authors： Anderson SE,Weatherly L,Shane HL

更新日期：2019-10-01 00:00:00

abstract：:Diseases due to defect in tolerance induction such as allergy, celiac disease, or Type 1 Diabetes develop mostly in childhood indicating the necessity of early intervention for primary prevention. Epidemiological studies report that breastfeeding could protect from these diseases. However, data are controversial and t...

journal_title：Current opinion in immunology

authors： Verhasselt V

更新日期：2010-10-01 00:00:00

abstract：:CD8(+) T cells are key effector cells of the adaptive immune system, however their activity must be tightly regulated to allow pathogen clearance whilst preventing immunopathology and autoimmunity. In this review, we summarise the diversity of responses that CD8(+) T cells make to antigenic stimulation with a focus on...

journal_title：Current opinion in immunology

authors： Parish IA,Kaech SM

更新日期：2009-06-01 00:00:00

abstract：:Recent advances in mass spectrometry technology have facilitated detailed examination of MHC-II immunopeptidomes, for example the repertoires of peptides bound to MHC-II molecules expressed in antigen presenting cells. These studies have deepened our view of MHC-II presentation. Other studies have broadened our view o...

journal_title：Current opinion in immunology

authors： Stern LJ,Santambrogio L

更新日期：2016-06-01 00:00:00

abstract：:In the last year progress has been made towards elucidating the roles of the MHC gene products in autoimmunity. A major advance has been the recent determination of the crystallographic structure of the human MHC class II molecule, which will be invaluable in delineating the minimum structural requirements for peptide...

journal_title：Current opinion in immunology

authors： Campbell RD,Milner CM

更新日期：1993-12-01 00:00:00

abstract：:The surface and lining tissues of our body are exposed to the external environment, and as such these epithelial tissues must form structural barriers able to defend against microbes, environmental toxins, and mechanical stress. Their cells are equipped to detect a diverse array of surface perturbations, and then laun...

journal_title：Current opinion in immunology

authors： Larsen SB,Cowley CJ,Fuchs E

更新日期：2020-02-01 00:00:00

abstract：:While certain bacteria and respiratory viruses promote local inflammation and disease onset, a more diverse colonization of the different species in the (gut) microbiome may be linked to more regulatory responses and protection against asthma and allergies. These processes are also influenced in part by food intake, b...

journal_title：Current opinion in immunology

authors： Smits HH,van der Vlugt LE,von Mutius E,Hiemstra PS

更新日期：2016-10-01 00:00:00

abstract：:Recent advances in the field of cellular therapy have focused on autologous T cells engineered to express a chimeric antigen receptor (CAR) against tumor antigens. Remarkable responses have been observed in patients receiving autologous CD19-redirected T cells for the treatment of B-lymphoid malignancies. However, the...

journal_title：Current opinion in immunology

authors： Daher M,Rezvani K

更新日期：2018-04-01 00:00:00

abstract：:The origin of the complement system is much more ancient than that of adaptive immunity, which is only found in jawed vertebrates. Recently, complement components of the alternative and lectin pathways have been identified in jawless fishes, and even in some deuterostome invertebrates. The primitive complement system ...

journal_title：Current opinion in immunology

authors： Nonaka M

更新日期：2001-02-01 00:00:00

abstract：:Natural killer cells are lymphocytes of the innate immune system that can kill an array of tumor and infected cells and secrete cytokines that participate in the shaping of the adaptive immune response. While it was believed that NK cell effector responses are acquired during maturation and then fixed, it appears that...

journal_title：Current opinion in immunology

authors： Narni-Mancinelli E,Ugolini S,Vivier E

更新日期：2013-02-01 00:00:00

abstract：:There is a growing appreciation for the role for B cells in autoimmune disorders in which inflammation is driven by T cells, in addition to the well-established role for B cells in autoimmune disorders characterized by pathogenic auto-antibodies. Current information on tolerance checkpoints in B cells, B cell depletio...

journal_title：Current opinion in immunology

authors： Pillai S,Mattoo H,Cariappa A

更新日期：2011-12-01 00:00:00

abstract：:Since the establishment of methods to isolate genes encoding cytotoxic T lymphocyte defined tumor antigens, several antigens have been identified and characterized for suitability as target antigens for immunotherapy. The development of innovative strategies to generate T cells targeting these antigens and lessons lea...

journal_title：Current opinion in immunology

authors： Yee C,Riddell SR,Greenberg PD

更新日期：1997-10-01 00:00:00

abstract：:Vaccines have been developed and deployed against several important bacterial pathogens of humans, including Neisseria meningitidis, Bordetella pertussis, Streptococcus pneumoniae and Mycobacterium tuberculosis. These vaccines are generally considered a successful public health measure and are effective at controlling...

journal_title：Current opinion in immunology

authors： Barnett TC,Lim JY,Soderholm AT,Rivera-Hernandez T,West NP,Walker MJ

更新日期：2015-10-01 00:00:00

abstract：:Rational selection of individual adjuvants can often be made on the basis of innate molecular interactions of the foreign molecules with pattern recognition receptors such as Toll-like receptors. For example, monophosphoryl lipid A, a family of endotoxic TLR4 agonist molecules from bacteria, has recently been formulat...

journal_title：Current opinion in immunology

authors： Alving CR,Peachman KK,Rao M,Reed SG

更新日期：2012-06-01 00:00:00

abstract：:Recent research has made great strides in uncovering the mechanisms by which the T helper 1 (Th1) cell gene expression program is established. In particular, studies examining the transcription factors T-bet, STAT1, and STAT4 have elucidated their roles in regulating Th1 signature genes, including Ifng, and have start...

journal_title：Current opinion in immunology

authors： Oestreich KJ,Weinmann AS

更新日期：2012-04-01 00:00:00

abstract：:Much has been learned recently about the structure and function of 55 kDa bactericidal/permeability-increasing protein (BPI), a member of a genomically conserved lipid-interactive protein family. Analysis of BPI fragments and the crystal structure of human BPI have established that BPI consists of two functionally dis...

journal_title：Current opinion in immunology

authors： Elsbach P,Weiss J

更新日期：1998-02-01 00:00:00

abstract：:Gene therapy has become an attractive alternative therapeutic strategy to allogeneic transplant for primary immunodeficiencies (PIDs) owing to known genetic defects. Clinical trials using gammaretroviral vectors have demonstrated the proof of principle of gene therapy for Wiskott-Aldrich syndrome (WAS) and chronic gra...

journal_title：Current opinion in immunology

authors： Aiuti A,Bacchetta R,Seger R,Villa A,Cavazzana-Calvo M

更新日期：2012-10-01 00:00:00

abstract：:Induction of antiviral immunity in vertebrates and invertebrates relies on members of the RIG-I-like receptor and Dicer families, respectively. Although these proteins have different size and domain composition, members of both families share a conserved DECH-box helicase domain. This helicase, also known as a duplex ...

journal_title：Current opinion in immunology

authors： Paro S,Imler JL,Meignin C

更新日期：2015-02-01 00:00:00

abstract：:The Toll-like receptors (TLRs) of the innate immune system detect host invasion by pathogens and initiate immune responses. All of the TLRs use the adaptor MyD88 to transduce a signal; however, two newly identified signaling molecules, TIRAP and TRIF, interact with a subset of the TLRs, suggesting a signaling specific...

journal_title：Current opinion in immunology

authors： Kopp E,Medzhitov R

更新日期：2003-08-01 00:00:00