Abstract:
:Vaccines have been developed and deployed against several important bacterial pathogens of humans, including Neisseria meningitidis, Bordetella pertussis, Streptococcus pneumoniae and Mycobacterium tuberculosis. These vaccines are generally considered a successful public health measure and are effective at controlling disease symptoms and/or burden. However, a troubling consequence of recent vaccination programs has been the selection of vaccine escape mutants, whereby the pathogen displays a different repertoire of immune targets than those represented in the vaccine formulation. To address these issues of antigenic variation and bacterial evolution, continued and sustained efforts in epidemiological surveillance, vaccine development/formulation research, and understanding of the host-pathogen interaction are required.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Barnett TC,Lim JY,Soderholm AT,Rivera-Hernandez T,West NP,Walker MJdoi
10.1016/j.coi.2015.04.002subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1-7eissn
0952-7915issn
1879-0372pii
S0952-7915(15)00059-Xjournal_volume
36pub_type
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