Abstract:
:The ensemble of antibodies found in serum and secretions represents the key adaptive component of B-cell mediated humoral immunity. The antibody repertoire is shaped by the historical record of exposure to exogenous factors such as pathogens and vaccines, as well as by endogenous host-intrinsic factors such as genetics, self-antigens, and age. Thanks to very recent technology advancements it is now becoming possible to identify and quantify the individual antibodies comprising the serological repertoire. In parallel, the advent of high throughput methods for antigen and immunosignature discovery opens up unprecedented opportunities to transform our understanding of numerous key questions in adaptive humoral immunity, including the nature and dynamics of serological memory, the role of polyspecific antibodies in health and disease and how protective responses to infections or vaccine challenge arise. Additionally, these technologies also hold great promise for therapeutic antibody and biomarker discovery in a variety of settings.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Wine Y,Horton AP,Ippolito GC,Georgiou Gdoi
10.1016/j.coi.2015.06.009subject
Has Abstractpub_date
2015-08-01 00:00:00pages
89-97eissn
0952-7915issn
1879-0372pii
S0952-7915(15)00090-4journal_volume
35pub_type
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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