Genomic-scale gene expression profiling of normal and malignant immune cells.

abstract：:The steep rise in the incidence and prevalence of food allergy (FA) in the last few decades have focused attention of environmental mechanisms which act to promote disease, chief among which is the microbiome. Recent studies have now established the presence of pathogenic dysbiosis in FA that could be precipitated by ...

journal_title：Current opinion in immunology

authors： Stephen-Victor E,Chatila TA

更新日期：2019-10-01 00:00:00

abstract：:Protective and pathogenic immune responses were initially thought to be determined by the differentiation of naïve T cells into Th1 and Th2 effector subsets and the immunosuppressive activity of thymic-derived regulatory T cells. It is now clear that naïve T cells can also differentiate into 'induced' regulatory T cel...

journal_title：Current opinion in immunology

authors： Sundrud MS,Rao A

更新日期：2007-06-01 00:00:00

abstract：:NKT cells utilize a restricted alphabeta TCR repertoire that recognizes glycolipids in association with CD1d. The recent development of fluorescent CD1d tetramers loaded with the synthetic glycolipid alpha-galactosyl-ceramide has led to a clearer definition of NKT-cell subsets as well as important insights into their ...

journal_title：Current opinion in immunology

authors： MacDonald HR

更新日期：2002-04-01 00:00:00

abstract：:Innate immunity, our inborn immediate defence mechanism, was thought for a long time to be non-specific and, consequently, research into innate mechanisms often took second place to research into adaptive immunity. In recent decades, however, the spotlight has shone on groundbreaking advances into mechanisms of innate...

journal_title：Current opinion in immunology

authors： Coutinho A,Poltorack A

更新日期：2003-12-01 00:00:00

abstract：:The application of molecularly defined vaccines composed of a limited number of tumor-specific T cell epitopes has resulted in protective antitumor T cell immunity in several mouse tumor models. The first encouraging results with such vaccines have been obtained in human beings. The development of the next generation ...

journal_title：Current opinion in immunology

authors： Melief CJ,Offringa R,Toes RE,Kast WM

更新日期：1996-10-01 00:00:00

abstract：:Cell death is an integral part of the functioning of the immune system. For T cells, potentially autoreactive or 'useless' cells are removed through apoptosis in response to signals (or lack of signals) from their T cell receptor complex. A myriad of proteins that can initiate or protect cells from cell death have rec...

journal_title：Current opinion in immunology

authors： Winoto A

更新日期：1997-06-01 00:00:00

abstract：:Cancer results from a tumor cell intrinsic dysregulation of oncogenes, tumor suppressor and stability genes as well as from the avoidance of immunosurveillance. A complex network of cellular interactions allows one to mount cognate anti-tumor immune responses. Recently, discoveries have been made regarding the links b...

journal_title：Current opinion in immunology

authors： Ghiringhelli F,Apetoh L,Housseau F,Kroemer G,Zitvogel L

更新日期：2007-04-01 00:00:00

abstract：:Lymphoid cell differentiation relies on precisely orchestrated gene activation and repression events. Gene targeting studies have demonstrated crucial roles for the transcription factors Ikaros and Aiolos in regulating multiple stages of B and T cell development. Recent experiments suggest that Ikaros and Aiolos set B...

journal_title：Current opinion in immunology

authors： Cortes M,Wong E,Koipally J,Georgopoulos K

更新日期：1999-04-01 00:00:00

abstract：:The rise in IgE-mediated food allergy in recent times is the likely result of gene-environment interactions mediated via epigenetic pathways. As epigenetic modifications, including DNA methylation, are at the interface between the environment and the genome, they may be ideal biomarkers of modifiable disease pathways....

journal_title：Current opinion in immunology

authors： Martino DJ,Saffery R,Allen KJ,Prescott SL

更新日期：2016-10-01 00:00:00

abstract：:The treatment of autoimmune diseases using conventional chemical immunosuppressants has short-term effects, imposing the need for chronic treatment with its risks of over-immunosuppression. CD3-specific monoclonal antibodies can restore self-tolerance in a durable fashion after a single short-term treatment, as demons...

journal_title：Current opinion in immunology

authors： Chatenoud L

更新日期：2005-12-01 00:00:00

abstract：:Antigens from a wide variety of pathogens have been identified as members of conserved heat-shock protein families, sharing upwards of 50% amino acid identity with corresponding host-cell proteins. Analysis of the responses to these conserved antigens may provide insights into regulation of the immune system during in...

journal_title：Current opinion in immunology

authors： Young DB

更新日期：1992-08-01 00:00:00

abstract：:One of the areas of greatest recent progress in immunology has been the elucidation of inhibitory receptors and their mode of signal transduction. A common feature of members of this growing family is expression of a conserved cytoplasmic sequence motif, the immunoreceptor tyrosine-based inhibitory motif, which functi...

journal_title：Current opinion in immunology

authors： Tamir I,Dal Porto JM,Cambier JC

更新日期：2000-06-01 00:00:00

abstract：:While remarkable progress has been made using genetically altered mice to understand the importance of different cytokines in protecting against experimental infections or co-infections, an examination of the opportunistic infections that occur during HIV infection of humans does not yet show a clear picture of cytoki...

journal_title：Current opinion in immunology

authors： Mosier DE

更新日期：1994-08-01 00:00:00

abstract：:Until very recently, the function of CD14 was thought to be limited to innate immune responses to bacterial and other microbial structures. It is now known that macrophage CD14 serves an additional unexpected function, namely as a receptor involved in the recognition and phagocytosis of cells undergoing apoptosis. In ...

journal_title：Current opinion in immunology

authors： Gregory CD

更新日期：2000-02-01 00:00:00

abstract：:Although autoantigen-induced negative selection plays an important role in shaping the mature B-cell repertoire, studies in recent years have suggested that differentiation into any of the three mature B-cell subsets (marginal zone B cells, follicular B cells and B-1 B cells) is not a passive product of autoreactive B...

journal_title：Current opinion in immunology

authors： Wang H,Clarke SH

更新日期：2004-04-01 00:00:00

abstract：:The extent of airway remodeling correlates with severity of asthma. Persistent airway hyperresponsiveness (AHR) is associated with airway remodeling, but not with inflammation. The increase in ASM mass is recognized as one of the most important factors related to AHR and to the severity of asthma. The infiltration of ...

journal_title：Current opinion in immunology

authors： Okayama Y,Ra C,Saito H

更新日期：2007-12-01 00:00:00

abstract：:Immunotherapy of cancer through adoptive transfer of genetically engineered T-cells constitutes a more powerful strategy than attempts to mobilize the endogenous T-cell repertoire. Application of this technology in patients offers great opportunities towards a long-awaited breakthrough in cancer immunotherapy. However...

journal_title：Current opinion in immunology

authors： Offringa R

更新日期：2009-04-01 00:00:00

abstract：:A little more than a decade after the explosion of research into recombinant live-attenuated or replication-deficient viruses as vaccine platforms, many viral vector-based vaccines have been licensed for animals. Progress has been slower for humans but 2011 will see the licensure of the first viral-vectored vaccine fo...

journal_title：Current opinion in immunology

authors： Rollier CS,Reyes-Sandoval A,Cottingham MG,Ewer K,Hill AV

更新日期：2011-06-01 00:00:00

abstract：:A major problem in the analysis of vaccine candidates is the lack of any agreed upon surrogates of efficacy, which means that for diseases that depend on a strong T cell response (HIV, TB especially) the only option is to perform an efficacy trial, involving thousands of subjects, enormous costs, and years before the ...

journal_title：Current opinion in immunology

authors： Davis MM

更新日期：2020-08-01 00:00:00

abstract：:The activation of T lymphocytes is initiated by the binding of MHC-peptide complexes on antigen-presenting cells to MHC-restricted, peptide specific TCRs. Significant progress has recently been made in understanding the structure of the TCR and in the direct quantitative examination of the primary binding interactions...

journal_title：Current opinion in immunology

authors： Margulies DH

更新日期：1997-06-01 00:00:00

abstract：:The use of colony stimulating factors in clinical bone marrow transplantation is rapidly evolving. Both granulocyte colony stimulating factor and granulocyte macrophage colony stimulating factor have shown efficacy in bone marrow transplant patients in accelerating the rate of myeloid recovery. The use of colony stimu...

journal_title：Current opinion in immunology

authors： Negrin RS,Greenberg PL

更新日期：1992-10-01 00:00:00

abstract：:Parasitic helminths continue to be a major cause of morbidity in human populations, particularly in the tropics and subtropics. The need for effective vaccines that minimize worm burdens, thus reducing associated pathology, is evident. With this goal in mind, an intense research effort is in progress to characterize i...

journal_title：Current opinion in immunology

authors： Wilson RA

更新日期：1993-08-01 00:00:00

abstract：:Natural killer T (NKT) cells are a distinct lymphocyte lineage that regulates immune responses. During their development in the thymus, immature uncommitted double-positive CD4+CD8+ thymocytes that rearrange the semi-invariant T-cell receptor found on mature NKT cells are positively selected by the non-classical MHC c...

journal_title：Current opinion in immunology

authors： Matsuda JL,Gapin L

更新日期：2005-04-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection is a global health problem. There are >350 million of people chronically infected with this virus worldwide. Hepatitis B vaccines are effective in preventing the infection. Humoral immunity is the key factor in conferring the protection. Hepatitis B surface antibody titers of ≥10mIU/m...

journal_title：Current opinion in immunology

authors： Huang LM,Lu CY,Chen DS

更新日期：2011-04-01 00:00:00

abstract：:Antigen presenting cells (APCs) alert the immune system to attack by extracellular organisms; APCs achieve this via internalization, degradation, and display of antigenic fragments on the cell surface by MHC class II molecules. These class II molecules bind to an accessory protein, termed the invariant chain, that ens...

journal_title：Current opinion in immunology

authors： Hiltbold EM,Roche PA

更新日期：2002-02-01 00:00:00

abstract：:There is a growing appreciation for the role for B cells in autoimmune disorders in which inflammation is driven by T cells, in addition to the well-established role for B cells in autoimmune disorders characterized by pathogenic auto-antibodies. Current information on tolerance checkpoints in B cells, B cell depletio...

journal_title：Current opinion in immunology

authors： Pillai S,Mattoo H,Cariappa A

更新日期：2011-12-01 00:00:00

abstract：:While mutations in human FOXP3 predispose individuals to autoimmune conditions, it is unclear how the mutant protein fails to function as a transcriptional regulator. There is also limited detail of how FOXP3 itself interacts with the transcriptional machinery and which components of the FOXP3 ensembles exert phenotyp...

journal_title：Current opinion in immunology

authors： Li B,Saouaf SJ,Samanta A,Shen Y,Hancock WW,Greene MI

更新日期：2007-10-01 00:00:00

abstract：:Typical immune responses lead to the prominent clonal expansion of antigen-specific T cells followed by their differentiation into effector cells. Most effector cells die at the end of the immune response but some of the responding cells survive and form long-lived memory cells. The factors controlling the formation a...

journal_title：Current opinion in immunology

authors： Sprent J,Surh CD

更新日期：2001-04-01 00:00:00

abstract：:Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is respon...

journal_title：Current opinion in immunology

authors： Boss JM

更新日期：1997-02-01 00:00:00

abstract：:Killer Ig-like receptors (KIRs) are surface inhibitory receptors specific for allelic forms of human leukocyte antigen (HLA) class I molecules, which are expressed by natural killer (NK) cells and a subset of T lymphocytes. Upon engagement with HLA class I molecules, KIRs block NK cell activation and function. Cells l...

journal_title：Current opinion in immunology

authors： Moretta L,Moretta A

更新日期：2004-10-01 00:00:00