Abstract：
:The application of molecularly defined vaccines composed of a limited number of tumor-specific T cell epitopes has resulted in protective antitumor T cell immunity in several mouse tumor models. The first encouraging results with such vaccines have been obtained in human beings. The development of the next generation of rationally designed vaccines that are both effective and safe for application in a clinical setting requires comparison of different modes of delivery of tumor-associated T cell epitopes in multiple epitope constructs.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Melief CJ,Offringa R,Toes RE,Kast WMdoi
10.1016/s0952-7915(96)80081-1subject
Has Abstractpub_date
1996-10-01 00:00:00pages
651-7issue
5eissn
0952-7915issn
1879-0372pii
S0952-7915(96)80081-1journal_volume
8pub_type
杂志文章,评审abstract：:Innate lymphoid cells (ILCs) constitute a heterogeneous population of cytokine-secreting cells that colonize different tissues and are heavily reliant on cytokines and other secreted factors for their development, maintenance and effector functions. Most ILCs are tissue resident and differentiate in non-lymphoid perip...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2018.11.004
更新日期：2019-02-01 00:00:00
abstract：:Type I and type II interferons (IFNα/β and IFNγ) are cytokines that play indispensable roles in directing myeloid cell activity during inflammatory and immune responses. Each IFN type binds a distinct receptor (IFNAR or IFNGR) to transduce signals that reshape gene expression and function of myeloid and other cell typ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2018.05.014
更新日期：2018-10-01 00:00:00
abstract：:Acute inflammatory responses are essential for pathogen control and tissue repair but can also cause severe collateral damage. Tight regulation of the response is required to minimize host injury, but in the face of chronic infections and age-associated immune dysregulation, inflammatory processes may exert multiple d...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2014.03.007
更新日期：2014-08-01 00:00:00
abstract：:T cell activation leads to a segregation of plasma membrane domains to form TCR signalling clusters and eventually immunological synapses. At these T cell activation sites signalling protein networks reside in plasma membrane regions which adopt a highly ordered physical state. Studies of reconstituted model membranes...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2007.05.002
更新日期：2007-08-01 00:00:00
abstract：:Clinical and experimental data now clearly indicate that chronic inflammation significantly contributes to cancer development. Emerging out of these studies is an appreciation that persistent humoral immune responses exacerbate recruitment and activation of innate immune cells in neoplastic microenvironments where the...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2007.01.001
更新日期：2007-04-01 00:00:00
abstract：:It has recently become clear that several factors must coincide for the initiation of autoimmunity. At minimum, these involve a genetic predisposition, naive lymphocytes that can react with autoantigens and a precipitating event that leads to T and/or B cell activation. Inter-individual variations in these factors pro...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2004.09.002
更新日期：2004-12-01 00:00:00
abstract：:Murine gamma-herpesvirus 68 (gammaHV68) infection is a new model for understanding how immunity and chronic gamma-herpesvirus infection inter-relate. gammaHV68 is closely related to the human Epstein-Barr virus and Kaposi's sarcoma herpesvirus and is associated with tumors, vasculitis of the great elastic arteries and...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(99)80063-6
更新日期：1999-08-01 00:00:00
abstract：:V(D)J recombination not only comprises the molecular mechanism that insures diversity of the immune system but also constitutes a critical checkpoint in the developmental program of B and T lymphocytes. The analysis of human patients with severe combined immune deficiency (SCID) has enabled (and will enable in the fut...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(03)00101-8
更新日期：2003-10-01 00:00:00
abstract：:Three known lineages of antigen-presenting molecules restrict T-cell responses to microbial antigens: MHC class I and MHC encoded class I like molecules present peptides derived from the proteolysis of intracellular pathogens, MHC class ii molecules present peptides derived from the proteolysis of extracellular pathog...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(96)80109-9
更新日期：1996-02-01 00:00:00
abstract：:V(D)J recombination in B and T cells is required for the generation of receptors with a broad spectrum of specificity to foreign antigen. A total number of three immunoglobulin (Ig) and four T cell receptor (Tcr) loci can be targeted by the recombinase enzyme (RAG1/2) in a defined series of recombination events, which...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2012.01.003
更新日期：2012-04-01 00:00:00
abstract：:Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place sp...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2020.08.003
更新日期：2020-10-07 00:00:00
abstract：:The pathogenesis of Crohn's disease (CD) has remained an enigma for at least a century. There was considerable optimism that genetic linkage and genome-wide association (GWA) studies had identified genes causally responsible. However, the realisation that these genes make a relatively minor contribution to the develop...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2009.06.003
更新日期：2009-10-01 00:00:00
abstract：:Macrophages have specialized functions in different tissue microenvironments such as lymphohaemopoietic organs and the nervous system. Recently, progress has been made in defining cellular and molecular properties of isolated and tissue macrophages in the developing and adult animal. ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(92)90119-y
更新日期：1992-02-01 00:00:00
abstract：:The emergence of new targeted therapies is rapidly improving the treatment of autoimmune disease. These drugs have been variably designed to deplete specific T and B cell subsets, interrupt receptor-ligand interactions, and inhibit the activity of inflammatory mediators relevant to immune function. Abatacept, a co-sti...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2009.09.008
更新日期：2009-12-01 00:00:00
abstract：:T cells are spared from programmed cell death in the thymus after an appropriate interaction between the T-cell receptor and a self peptide/MHC complex; this step is referred to as positive selection. Recent work has focused on precise identification of the positively selecting ligand, and the cell that presents it. F...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(94)90101-5
更新日期：1994-04-01 00:00:00
abstract：:Thymocytes co-expressing the CD4 and CD8 co-receptors differentiate into mature T cells that express either CD4 or CD8 and have helper or cytotoxic functions, respectively. Recent studies indicate that commitment to the CD4+ or CD8+ lineages occurs stochastically, but retention of the appropriate co-receptor is requir...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(94)90100-7
更新日期：1994-04-01 00:00:00
abstract：:During the first week after sexual exposure to HIV, HIV infection does not appear to trigger a strong innate immune response. Here we describe some recent studies that show that HIV may avoid triggering antiviral innate immune responses by not replicating efficiently in dendritic cells and by avoiding detection in inf...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2010.11.004
更新日期：2011-02-01 00:00:00
abstract：:We are in a 'golden age' of mouse genetics. Genetic engineering and micromanipulation techniques now allow not only the overexpression or misexpression of transgenes randomly inserted into the mouse genome, but also the directed homologous replacement of normal genes with transgenes coding for null or mutant alleles (...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(95)80075-1
更新日期：1995-10-01 00:00:00
abstract：:While mutations in human FOXP3 predispose individuals to autoimmune conditions, it is unclear how the mutant protein fails to function as a transcriptional regulator. There is also limited detail of how FOXP3 itself interacts with the transcriptional machinery and which components of the FOXP3 ensembles exert phenotyp...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2007.07.006
更新日期：2007-10-01 00:00:00
abstract：:The nuclear factor κ enhancer binding protein (NF-κB) family of transcription factors regulates the expression of a large array of genes involved in diverse cellular processes including inflammation, immunity and cell survival. Activation of NF-κB requires ubiquitination, a highly conserved and versatile modification ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2012.12.005
更新日期：2013-02-01 00:00:00
abstract：:Vaccines prophylactic against infection with human papillomavirus (HPV) are based on alum adjuvanted virus-like particles. Two such vaccines have recently been shown to prevent persistent HPV infection and associated cervical cancer precursor lesions. The genotype-specific neutralising antibody directed at conformatio...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2007.01.004
更新日期：2007-04-01 00:00:00
abstract：:Current models suggest that continuous antigenic stimulation of memory B cells is required to maintain long-term antibody production. In view of recent developments concerning plasma cell longevity, a new model is described that incorporates the important role of long-lived plasma cells in sustaining persistent antibo...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(98)80162-3
更新日期：1998-06-01 00:00:00
abstract：:Theileria parasites infect and transform cells of the ruminant immune system. Continuous proliferation and survival of Theileria-transformed cells involves the well-orchestrated activation of several host-cell signalling pathways. Constitutive NF-kappa B (nuclear factor kappa B) activation is accomplished by recruitin...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2004.05.009
更新日期：2004-08-01 00:00:00
abstract：:Simply detecting the presence or absence of Foxp3, a transcription factor characteristic of naturally occurring CD4+ CD25+ regulatory T cells (Tregs), now appears of minimal value in predicting the outcome of immunologic responses, since dividing human CD4+ effector T cells can induce Foxp3 without attaining repressiv...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2007.07.015
更新日期：2007-10-01 00:00:00
abstract：:Discovered during the past ten years, Janus kinases and signal transducers and activators of transcription have emerged as critical elements in cytokine signaling and immunoregulation. Recently, knockout mice for all the members of these families have been generated, with remarkably specific outcomes. Equally exciting...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(00)00228-4
更新日期：2001-06-01 00:00:00
abstract：:Viruses that establish persistent infections in their host, such as herpesviruses, adenoviruses or HIV, express proteins designed to pre-empt or evade recognition and elimination by MHC class I restricted CD8+ T lymphocytes. Notable discoveries during the annual period of review have demonstrated that, in principle, e...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(97)80097-0
更新日期：1997-08-01 00:00:00
abstract：:Immunotherapy of cancer with blockade of inhibitory immune checkpoints and adoptive cell therapies have led to impressive clinical responses in several cancers. However, with increasing utilization of these therapies, immune-related adverse events have emerged as a major obstacle. Herein I discuss recent insights into...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2019.08.004
更新日期：2019-12-01 00:00:00
abstract：:Perforin defects have been identified in humans with familial hematophagocytic lymphohistiocytosis. The pathology of these patients has dramatically illustrated an under-appreciated role for perforin in the regulation of T-cell responses in vivo, and experimental studies are shedding light on the mechanisms involved. ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(03)00114-6
更新日期：2003-10-01 00:00:00
abstract：:T-lymphocyte activation is initiated by the interaction of the alpha beta TCR with a complex consisting of a class I or class II MHC-encoded molecule and an antigenic peptide, displayed on the surface of an antigen-presenting cell. Real-time binding measurements using surface plasmon resonance have revealed kinetic an...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(96)80066-5
更新日期：1996-04-01 00:00:00
abstract：:A diverse B cell repertoire is essential for an effective immune response. Not only to provide a variety of antibodies to recognise the multiplicity of likely pathogen challenge, but also because B cells are important regulators of the immune response. In addition to their excellent capabilities as antigen presenting ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2010.04.009
更新日期：2010-08-01 00:00:00
