Abstract：
:T cells are spared from programmed cell death in the thymus after an appropriate interaction between the T-cell receptor and a self peptide/MHC complex; this step is referred to as positive selection. Recent work has focused on precise identification of the positively selecting ligand, and the cell that presents it. First, it was shown that bone marrow derived cells or fibroblasts can substitute for epithelial cells in providing the ligand for positive selection. Second, in a T-cell receptor transgenic system, variants of the antigenic peptides were found to induce positive selection. Peptides that served as antagonists or weak agonists for the T-cell receptor efficiently selected immature thymocytes for survival. It appears that the peptide ligands for positive selection of T cells are self peptides, which serve as mimics or look alikes for the universe of pathogen peptides. The challenge remains to identify a naturally occurring thymic self peptide that can cause positive selection and determine the range of reactivities to foreign peptides which it can select.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Hogquist KA,Jameson SC,Bevan MJdoi
10.1016/0952-7915(94)90101-5subject
Has Abstractpub_date
1994-04-01 00:00:00pages
273-8issue
2eissn
0952-7915issn
1879-0372pii
0952-7915(94)90101-5journal_volume
6pub_type
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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