Cellular pathways in the development of human and murine innate lymphoid cells.

abstract：:Experimental models of transplantation provide strong support for the role of regulatory cells in tolerance. However, limited studies of humans who display sustained tolerance following transplantation have not definitively demonstrated a role for regulatory cells in this process. Rather than excluding or minimizing t...

journal_title：Current opinion in immunology

authors： Newell KA,Phippard D,Turka LA

更新日期：2011-10-01 00:00:00

abstract：:While mutations in human FOXP3 predispose individuals to autoimmune conditions, it is unclear how the mutant protein fails to function as a transcriptional regulator. There is also limited detail of how FOXP3 itself interacts with the transcriptional machinery and which components of the FOXP3 ensembles exert phenotyp...

journal_title：Current opinion in immunology

authors： Li B,Saouaf SJ,Samanta A,Shen Y,Hancock WW,Greene MI

更新日期：2007-10-01 00:00:00

abstract：:Dendritic cells (DCs) with their potent antigen presenting ability are long considered as critical factor in antitumor immunity. Despite high potential in promoting antitumor responses, tumor-associated DCs are largely defective in their functional activity and can contribute to immune suppression in cancer. In recent...

journal_title：Current opinion in immunology

authors： Veglia F,Gabrilovich DI

更新日期：2017-04-01 00:00:00

abstract：:Proteasomes are large multicatalytic proteinase complexes which are responsible for the selective degradation of cellular proteins and the production of peptides for antigen presentation. Proteasomes are localized both in the nucleus and in the cytoplasm, where some are associated with the endoplasmic reticulum membra...

journal_title：Current opinion in immunology

authors： Rivett AJ

更新日期：1998-02-01 00:00:00

abstract：:The adoptive transfer of donor-type CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) protects from graft-versus-host disease in murine bone marrow transplantation models. Results from first clinical trials exploring such strategies have recently been presented and seem to confirm the efficacy of Treg for the prevention...

journal_title：Current opinion in immunology

authors： Edinger M,Hoffmann P

更新日期：2011-10-01 00:00:00

abstract：:A little more than a decade after the explosion of research into recombinant live-attenuated or replication-deficient viruses as vaccine platforms, many viral vector-based vaccines have been licensed for animals. Progress has been slower for humans but 2011 will see the licensure of the first viral-vectored vaccine fo...

journal_title：Current opinion in immunology

authors： Rollier CS,Reyes-Sandoval A,Cottingham MG,Ewer K,Hill AV

更新日期：2011-06-01 00:00:00

abstract：:The concept of induction immunosuppression is evolving. Once used to buttress the inadequacies of past maintenance immunosuppressive regimens, it is now being used to permit effective maintenance immunosuppression using ever decreasing amounts of modern agents. In addition to lymphocyte depletion, with which it was on...

journal_title：Current opinion in immunology

authors： Hale DA

更新日期：2004-10-01 00:00:00

abstract：:Immunity to intracellular pathogens and cancer relies on the generation of robust CD8(+) T cell effector responses as well as the establishment of immunological memory. During a primary immune response CD8(+) T cells experience diverse extracellular environmental cues and cell-cell interactions that trigger downstream...

journal_title：Current opinion in immunology

authors： Thaventhiran JE,Fearon DT,Gattinoni L

更新日期：2013-06-01 00:00:00

abstract：:Many of the pathogens that cause human infectious diseases do not infect rodents or other mammalian species. Small animal models that allow studies of the pathogenesis of these agents and evaluation of drug efficacy are critical for identifying ways to prevent and treat human infectious diseases. Immunodeficient mice ...

journal_title：Current opinion in immunology

authors： Brehm MA,Jouvet N,Greiner DL,Shultz LD

更新日期：2013-08-01 00:00:00

abstract：:Recent advances in the field of cellular therapy have focused on autologous T cells engineered to express a chimeric antigen receptor (CAR) against tumor antigens. Remarkable responses have been observed in patients receiving autologous CD19-redirected T cells for the treatment of B-lymphoid malignancies. However, the...

journal_title：Current opinion in immunology

authors： Daher M,Rezvani K

更新日期：2018-04-01 00:00:00

abstract：:Simply detecting the presence or absence of Foxp3, a transcription factor characteristic of naturally occurring CD4+ CD25+ regulatory T cells (Tregs), now appears of minimal value in predicting the outcome of immunologic responses, since dividing human CD4+ effector T cells can induce Foxp3 without attaining repressiv...

journal_title：Current opinion in immunology

authors： Tao R,de Zoeten EF,Ozkaynak E,Wang L,Li B,Greene MI,Wells AD,Hancock WW

更新日期：2007-10-01 00:00:00

abstract：:The strong genetic association of ERAP1 (endoplasmic reticulum aminopeptidase 1) with ankylosing spondylitis (AS), which is restricted to HLA-B27 positive cases, has profound pathogenetic implications. ERAP1 is involved in trimming peptides to optimal length for binding to HLA class 1 molecules, thereby not only affec...

journal_title：Current opinion in immunology

authors： Keidel S,Chen L,Pointon J,Wordsworth P

更新日期：2013-02-01 00:00:00

abstract：:Immunological memory can be regulated during either its development or its maintenance phases. Controversy and confusion surround both methods of regulation, especially in the field of T-cell memory. Recent work has helped in improving our definition of 'a memory cell', but this has been complicated by another major p...

journal_title：Current opinion in immunology

authors： Gray D

更新日期：1994-06-01 00:00:00

abstract：:The nuclear factor κ enhancer binding protein (NF-κB) family of transcription factors regulates the expression of a large array of genes involved in diverse cellular processes including inflammation, immunity and cell survival. Activation of NF-κB requires ubiquitination, a highly conserved and versatile modification ...

journal_title：Current opinion in immunology

authors： Chen J,Chen ZJ

更新日期：2013-02-01 00:00:00

abstract：:Basophils are important effector cells, which contribute to protection against helminths and execute proinflammatory effector function during allergic inflammation. Basophils are also regulators of Th2 responses in helminth-infected hosts and in allergen-injected animals. Recently, three groups using different experim...

journal_title：Current opinion in immunology

authors： Nakanishi K

更新日期：2010-12-01 00:00:00

abstract：:Islets of Langerhans of all species harbor a small number of resident macrophages. These macrophages are found since birth, do not exchange with blood monocytes, and are maintained by a low level of replication. Under steady state conditions, the islet macrophages are in an activated state. Islet macrophages have an i...

journal_title：Current opinion in immunology

authors： Carrero JA,Ferris ST,Unanue ER

更新日期：2016-12-01 00:00:00

abstract：:The classification of T helper (T(H)) cells in subsets has progressively expanded and more effector subsets, besides T(H)1 and T(H)2, have been documented. These include follicular helper T cells (T(FH)), and the more recent T(H)17, 'T(H)9', and 'T(H)22'. In addition, T(H) are no longer thought of as terminally commit...

journal_title：Current opinion in immunology

authors： Veldhoen M

更新日期：2009-12-01 00:00:00

abstract：:Immune system function declines with age. Here we review and compare age-associated changes in murine and human B cell pools and humoral immune responses. We summarize changes in B cell generation and homeostasis, as well as notable changes at the subcellular level; then discuss how these changes help to explain alter...

journal_title：Current opinion in immunology

authors： Scholz JL,Diaz A,Riley RL,Cancro MP,Frasca D

更新日期：2013-08-01 00:00:00

abstract：:Graft versus host disease (GVHD) remains the major obstacle to the application of bone marrow transplantation across HLA barriers. Recent advances in our understanding of GVHD pathophysiology have resulted in the evaluation in animal models and in clinical trials of some novel approaches to avoiding and treating GVHD....

journal_title：Current opinion in immunology

authors： Sykes M

更新日期：1993-10-01 00:00:00

abstract：:The presentation of antigenic peptides by MHC class I molecules plays a vital role in generating T cell responses against infection and cancer. Over the last two decades the central role of tapasin as a peptide editor that influences the loading and optimisation of peptides onto MHC class I molecules has been extensiv...

journal_title：Current opinion in immunology

authors： Neerincx A,Boyle LH

更新日期：2017-06-01 00:00:00

abstract：:Tumors of diverse origin have recently been shown to express CD95 ligand and to induce apoptosis in CD95-expressing targets in vitro; however, in vivo, enhanced tumor growth and rejection have both been observed as a consequence of either immunosuppressive or proinflammatory functions of CD95 ligand. The final in vivo...

journal_title：Current opinion in immunology

authors： Walker PR,Saas P,Dietrich PY

更新日期：1998-10-01 00:00:00

abstract：:Recent research has made great strides in uncovering the mechanisms by which the T helper 1 (Th1) cell gene expression program is established. In particular, studies examining the transcription factors T-bet, STAT1, and STAT4 have elucidated their roles in regulating Th1 signature genes, including Ifng, and have start...

journal_title：Current opinion in immunology

authors： Oestreich KJ,Weinmann AS

更新日期：2012-04-01 00:00:00

abstract：:Rapid progress in the discovery of members of the tumor necrosis factor receptor/ligand superfamilies has been made, mainly with the help of massive DNA sequencing and bioinformatic studies. Biological studies of the new members have not only indicated overlapping roles with other members but also provided insights in...

journal_title：Current opinion in immunology

authors： Kwon B,Youn BS,Kwon BS

更新日期：1999-06-01 00:00:00

abstract：:Significant insight has been gained into constraints on the sensitivity and specificity of staining with class I tetramers. The function of the populations that are defined varies with the clinical situation. Insight has also been gained into the determinants of the CD8(+) T cell response during primary and chronic HI...

journal_title：Current opinion in immunology

authors： Kelleher AD,Rowland-Jones SL

更新日期：2000-08-01 00:00:00

abstract：:Asthma, one of the most common chronic diseases, is a complex and heterogeneous disorder. The results of genome screens for asthma-related traits in 11 different populations identified at least 18 regions of the genome that probably house asthma/atopy genes. The most consistently replicated regions are on chromosomes ...

journal_title：Current opinion in immunology

authors： Hoffjan S,Ober C

更新日期：2002-12-01 00:00:00

abstract：:The innate immune system is comprised of a sophisticated network of recognition and effector molecules that act together to protect the host in the first minutes or hours of exposure to an infectious challenge. The mannose-binding lectin (MBL) is an evolutionary conserved circulating host defense protein that acts as ...

journal_title：Current opinion in immunology

authors： Takahashi K,Ip WE,Michelow IC,Ezekowitz RA

更新日期：2006-02-01 00:00:00

abstract：:Antimicrobials represent a broad class of chemicals with the intended purpose of eliminating or controlling the growth of harmful microorganisms. Exposure can occur occupationally or through the use or consumption of consumer products. The use of antimicrobial agents has been associated with an increased incidence of ...

journal_title：Current opinion in immunology

authors： Anderson SE,Weatherly L,Shane HL

更新日期：2019-10-01 00:00:00

abstract：:Antiviral T-cell responses between individuals that have similar major histocompatibility complex molecules share similarities in epitope hierarchies and T-cell receptor variable gene usage (public specificities), yet the T-cell receptor amino acid sequences differ between individuals (private specificities). The sign...

journal_title：Current opinion in immunology

authors： Welsh RM

更新日期：2006-06-01 00:00:00

abstract：:The past few years have seen significant growth in the number of known chemokines. Along with expansion in this field has come an appreciation of a role for chemokines beyond the chemotaxis of leukocytes. In particular, it appears that these molecules may represent major products of activated lymphocytes and that, in ...

journal_title：Current opinion in immunology

authors： Hedrick JA,Zlotnik A

更新日期：1996-06-01 00:00:00

abstract：:T cell antigen receptor-induced signals are required for normal T cell development and function. Recent studies have investigated the mechanism(s) by which signals of different strengths are converted into distinct cellular fates during thymocyte development. These studies indicate the importance of the strength and d...

journal_title：Current opinion in immunology

authors： Love PE,Chan AC

更新日期：2003-04-01 00:00:00