Abstract：
:Immunity to intracellular pathogens and cancer relies on the generation of robust CD8(+) T cell effector responses as well as the establishment of immunological memory. During a primary immune response CD8(+) T cells experience diverse extracellular environmental cues and cell-cell interactions that trigger downstream transcriptional programs ultimately guiding a CD8(+) T cell to undertake either an effector or a memory cell fate. Here, we discuss our current understanding of the signaling pathways and transcriptional networks that regulate effector and memory commitment in CD8(+) T lymphocytes.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Thaventhiran JE,Fearon DT,Gattinoni Ldoi
10.1016/j.coi.2013.05.010subject
Has Abstractpub_date
2013-06-01 00:00:00pages
321-8issue
3eissn
0952-7915issn
1879-0372pii
S0952-7915(13)00080-0journal_volume
25pub_type
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2018.03.008
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