Helminth-induced regulatory T cells and suppression of allergic responses.

abstract：:Commensal bacterial communities residing within the intestinal lumen of mammals have evolved to flourish in this microenvironment. To preserve this niche, commensal bacteria act with the host to prevent colonization by invasive pathogens that induce inflammation and disrupt the intestinal niche commensal bacteria occu...

journal_title：Current opinion in immunology

authors： Abt MC,Pamer EG

更新日期：2014-08-01 00:00:00

abstract：:T cell activation leads to a segregation of plasma membrane domains to form TCR signalling clusters and eventually immunological synapses. At these T cell activation sites signalling protein networks reside in plasma membrane regions which adopt a highly ordered physical state. Studies of reconstituted model membranes...

journal_title：Current opinion in immunology

authors： Harder T,Rentero C,Zech T,Gaus K

更新日期：2007-08-01 00:00:00

abstract：:T cell antigen receptor-induced signals are required for normal T cell development and function. Recent studies have investigated the mechanism(s) by which signals of different strengths are converted into distinct cellular fates during thymocyte development. These studies indicate the importance of the strength and d...

journal_title：Current opinion in immunology

authors： Love PE,Chan AC

更新日期：2003-04-01 00:00:00

abstract：:Defensins are a component of the host response against bacterial infections. Multiple studies suggest a linked upregulation of beta-defensins and pro-inflammatory cytokines expression in various tissues, as well as the possibility of mutual induction. Recent data demonstrate the importance of nucleotide-binding oligom...

journal_title：Current opinion in immunology

authors： Menendez A,Brett Finlay B

更新日期：2007-08-01 00:00:00

abstract：:The development of novel vaccine candidates against infections with Mycobacterium tuberculosis has highlighted our limited understanding of immune mechanisms required to kill M. tuberculosis. The induction of a Th1 immunity is vital, but new studies are required to identify other mechanisms that may be necessary. Nove...

journal_title：Current opinion in immunology

authors： Izzo AA

更新日期：2017-08-01 00:00:00

abstract：:The strong genetic association of ERAP1 (endoplasmic reticulum aminopeptidase 1) with ankylosing spondylitis (AS), which is restricted to HLA-B27 positive cases, has profound pathogenetic implications. ERAP1 is involved in trimming peptides to optimal length for binding to HLA class 1 molecules, thereby not only affec...

journal_title：Current opinion in immunology

authors： Keidel S,Chen L,Pointon J,Wordsworth P

更新日期：2013-02-01 00:00:00

abstract：:Malaria remains one of the greatest impediments to development in many tropical regions of the world. Understanding host immune responses to malaria parasites is crucial for the effective design and implementation of new vaccines and drugs. Recent research has seen the identification of the first pattern recognition r...

journal_title：Current opinion in immunology

authors： Engwerda CR,Good MF

更新日期：2005-08-01 00:00:00

abstract：:Atopic dermatitis is a chronic inflammatory skin disease associated with elevated serum IgE levels and sensitization to a variety of inhalant, food and microbial allergens. Controlled challenges have provided substantial evidence that allergens can trigger acute IgE-mediated mast-cell dependent exacerbations of eczema...

journal_title：Current opinion in immunology

authors： Leung DY

更新日期：1993-12-01 00:00:00

abstract：:During the past couple of years there has been significant progress in our understanding of the development of different lineages of T cells within the thymus. Pathways, subpopulations and cellular dynamics are all becoming clearer. Signal transduction through primary and accessory receptors is also beginning to be un...

journal_title：Current opinion in immunology

authors： Scollay R

更新日期：1991-04-01 00:00:00

abstract：:Viruses that establish persistent infections in their host, such as herpesviruses, adenoviruses or HIV, express proteins designed to pre-empt or evade recognition and elimination by MHC class I restricted CD8+ T lymphocytes. Notable discoveries during the annual period of review have demonstrated that, in principle, e...

journal_title：Current opinion in immunology

authors： Hengel H,Koszinowski UH

更新日期：1997-08-01 00:00:00

abstract：:One hundred years ago, the 1918 H1N1 Pandemic killed 20 million people worldwide. Despite the introduction of a worldwide surveillance system, large-scale production of influenza vaccines coupled with annual vaccination schemes, influenza remains a major public health concern. Prevention of influenza on a population b...

journal_title：Current opinion in immunology

authors： Andrews SF,McDermott AB

更新日期：2018-08-01 00:00:00

abstract：:The adoptive transfer of T cells engineered to express artificial chimeric antigen receptors CARs) that target a tumor cell surface molecule has emerged as an exciting new approach for cancer immunotherapy. Clinical trials in patients with advanced B cell malignancies treated with CD19-specific CAR-modified T cells (C...

journal_title：Current opinion in immunology

authors： Jensen MC,Riddell SR

更新日期：2015-04-01 00:00:00

abstract：:Antiviral T-cell responses between individuals that have similar major histocompatibility complex molecules share similarities in epitope hierarchies and T-cell receptor variable gene usage (public specificities), yet the T-cell receptor amino acid sequences differ between individuals (private specificities). The sign...

journal_title：Current opinion in immunology

authors： Welsh RM

更新日期：2006-06-01 00:00:00

abstract：:Acute inflammatory responses are essential for pathogen control and tissue repair but can also cause severe collateral damage. Tight regulation of the response is required to minimize host injury, but in the face of chronic infections and age-associated immune dysregulation, inflammatory processes may exert multiple d...

journal_title：Current opinion in immunology

authors： Pawelec G,Goldeck D,Derhovanessian E

更新日期：2014-08-01 00:00:00

abstract：:A subfamily of serine proteases is uniquely expressed by cytotoxic natural killer lymphocytes and T cells. Protease cleavage of different natural substrates is now implicated in the cytotoxic mechanisms of target cell membrane pore formation, DNA fragmentation and cytostasis. ...

journal_title：Current opinion in immunology

authors： Hudig D,Ewoldt GR,Woodard SL

更新日期：1993-02-01 00:00:00

abstract：:The germinal centre (GC) is a specialized cellular structure that forms in response to antigenic stimulation. It generates long-term humoral immunity through the production of memory B cells and long-lived antibody-secreting plasma cells. Conventional GCs form within secondary lymphoid organs, where networks of specia...

journal_title：Current opinion in immunology

authors： Silva-Cayetano A,Linterman MA

更新日期：2020-04-20 00:00:00

abstract：:Vascular endothelial cells participate in the process of allograft rejection by promoting both the recruitment and the activation of alloreactive T cells. There have been three major recent advances in the field of interactions between T cells and endothelial cells that are of direct relevance to the process of cell-m...

journal_title：Current opinion in immunology

authors： Briscoe DM,Alexander SI,Lichtman AH

更新日期：1998-10-01 00:00:00

abstract：:The treatment of autoimmune diseases using conventional chemical immunosuppressants has short-term effects, imposing the need for chronic treatment with its risks of over-immunosuppression. CD3-specific monoclonal antibodies can restore self-tolerance in a durable fashion after a single short-term treatment, as demons...

journal_title：Current opinion in immunology

authors： Chatenoud L

更新日期：2005-12-01 00:00:00

abstract：:The origin of the complement system is much more ancient than that of adaptive immunity, which is only found in jawed vertebrates. Recently, complement components of the alternative and lectin pathways have been identified in jawless fishes, and even in some deuterostome invertebrates. The primitive complement system ...

journal_title：Current opinion in immunology

authors： Nonaka M

更新日期：2001-02-01 00:00:00

abstract：:A two chain model, composed of ligand-binding and signal transducing subunits, first identified in the interleukin-6 receptor system, has been revealed in several other cytokine systems. Common signal transducers shared by several receptor systems may explain a functional redundancy characteristic of cytokines. The si...

journal_title：Current opinion in immunology

authors： Akira S,Kishimoto T

更新日期：1992-06-01 00:00:00

abstract：:Dendritic cells (DCs) with their potent antigen presenting ability are long considered as critical factor in antitumor immunity. Despite high potential in promoting antitumor responses, tumor-associated DCs are largely defective in their functional activity and can contribute to immune suppression in cancer. In recent...

journal_title：Current opinion in immunology

authors： Veglia F,Gabrilovich DI

更新日期：2017-04-01 00:00:00

abstract：:The mesenchymal microenvironment is increasingly recognized as a major player in immunity. Here we focus on mesenchymal cells located within or in proximity to the blood vessels wall, which include pericytes, adventitial fibroblasts and mesenchymal stromal cells. We discuss recent evidence that these cells play a role...

journal_title：Current opinion in immunology

authors： Benabid A,Peduto L

更新日期：2020-05-06 00:00:00

abstract：:Allergen immunotherapy leads to tolerance through multiple mechanisms that include tolerogenic dendritic cells and T and B regulatory cells. These induced cellular populations produce mediators to skew the immune response to a tolerogenic milieu that, among others, results in IgG4 blocking antibodies formation and low...

journal_title：Current opinion in immunology

authors： Mitsias DI,Xepapadaki P,Makris M,Papadopoulos NG

更新日期：2020-10-01 00:00:00

abstract：:Not surprisingly, most of the publications on enzyme immunoassays or latex agglutination tests in 1990 have been applications for specific antigens or antibodies. Nevertheless, a large number of studies of considerable interest to all users have been reported. In this short review, we have chosen to highlight investig...

journal_title：Current opinion in immunology

authors： Tijssen P,Adam A

更新日期：1991-04-01 00:00:00

abstract：:MHC class I molecules present degradation products derived from intracellular proteins, whereas MHC class II molecules generally present peptides derived from extracellular or surface proteins. Recent insights into the cell biology of MHC class I and II molecules explain this difference. ...

journal_title：Current opinion in immunology

authors： Neefjes JJ,Momburg F

更新日期：1993-02-01 00:00:00

abstract：:The past year has seen significant advances in our understanding of critical roles of negative immunoregulatory signals delivered through the B7-CD28 superfamily in regulating T cell activation and tolerance. Structural data on CTLA-4 have provided novel insights into the inhibitory functions of CTLA-4. Initial charac...

journal_title：Current opinion in immunology

authors： Greenwald RJ,Latchman YE,Sharpe AH

更新日期：2002-06-01 00:00:00

abstract：:Gene therapy has become an attractive alternative therapeutic strategy to allogeneic transplant for primary immunodeficiencies (PIDs) owing to known genetic defects. Clinical trials using gammaretroviral vectors have demonstrated the proof of principle of gene therapy for Wiskott-Aldrich syndrome (WAS) and chronic gra...

journal_title：Current opinion in immunology

authors： Aiuti A,Bacchetta R,Seger R,Villa A,Cavazzana-Calvo M

更新日期：2012-10-01 00:00:00

abstract：:Successful vaccination relies on driving the immune response towards high specificity, affinity and longevity. Germinal centers facilitate the evolution of antigen-specific B cells by iterative rounds of diversification, selection, and differentiation to memory and plasma cells. Experimental evidence points to B cell ...

journal_title：Current opinion in immunology

authors： Dufaud CR,McHeyzer-Williams LJ,McHeyzer-Williams MG

更新日期：2017-04-01 00:00:00

abstract：:V(D)J recombination in B and T cells is required for the generation of receptors with a broad spectrum of specificity to foreign antigen. A total number of three immunoglobulin (Ig) and four T cell receptor (Tcr) loci can be targeted by the recombinase enzyme (RAG1/2) in a defined series of recombination events, which...

journal_title：Current opinion in immunology

authors： Chaumeil J,Skok JA

更新日期：2012-04-01 00:00:00

abstract：:The adoptive transfer of donor-type CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) protects from graft-versus-host disease in murine bone marrow transplantation models. Results from first clinical trials exploring such strategies have recently been presented and seem to confirm the efficacy of Treg for the prevention...

journal_title：Current opinion in immunology

authors： Edinger M,Hoffmann P

更新日期：2011-10-01 00:00:00