Cell biology of antigen presentation.

abstract：:Defining the immunological goals for respiratory syncytial virus (RSV) vaccination requires understanding of RSV biology and tropism, mechanisms of cell-to-cell spread and immunity, epidemiology, and transmission dynamics. The immunological goals for a particular vaccine would be product-specific based on antigen sele...

journal_title：Current opinion in immunology

authors： Graham BS

更新日期：2019-08-01 00:00:00

abstract：:Plants have the capacity to recognise and reject pathogens at various stages of their attempted colonisation of the plant. Non-specific rejection often arises as a consequence of the potential pathogen's attempt to breach the first lines of plant defence. Pathogens able to penetrate beyond this barrier of non-host res...

journal_title：Current opinion in immunology

authors： Jones DA,Takemoto D

更新日期：2004-02-01 00:00:00

abstract：:The usefulness of molecular diagnosis is now well established for genetically determined recurrent fevers. In familial Mediterranean fever, the severity of the disease and the risk of renal amyloidosis are correlated with mutations in MEFV, and the serum amyloid-associated protein (SAA)1 alpha/alpha allele is a modify...

journal_title：Current opinion in immunology

authors： Delpech M,Grateau G

更新日期：2001-10-01 00:00:00

abstract：:It has recently become clear that several factors must coincide for the initiation of autoimmunity. At minimum, these involve a genetic predisposition, naive lymphocytes that can react with autoantigens and a precipitating event that leads to T and/or B cell activation. Inter-individual variations in these factors pro...

journal_title：Current opinion in immunology

authors： Christen U,von Herrath MG

更新日期：2004-12-01 00:00:00

abstract：:The polymerase chain reaction allows the characterization of RNA and DNA sequences in samples as small as a single cell. The recent development of amplification systems designed to isolate rearranged immunoglobulin genes from single B lineage cells has provided a powerful tool to investigate various aspects of B-cell ...

journal_title：Current opinion in immunology

authors： Ehlich A,Küppers R

更新日期：1995-04-01 00:00:00

abstract：:There is a growing appreciation for the role for B cells in autoimmune disorders in which inflammation is driven by T cells, in addition to the well-established role for B cells in autoimmune disorders characterized by pathogenic auto-antibodies. Current information on tolerance checkpoints in B cells, B cell depletio...

journal_title：Current opinion in immunology

authors： Pillai S,Mattoo H,Cariappa A

更新日期：2011-12-01 00:00:00

abstract：:Mucosal vaccines may be used both to prevent mucosal infections through the activation of antimicrobial immunity and to treat systemic inflammatory diseases through the induction of antigen-specific mucosal tolerance. New, efficient mucosal adjuvants for human use have been designed based on, amongst others, bacterial...

journal_title：Current opinion in immunology

authors： Eriksson K,Holmgren J

更新日期：2002-10-01 00:00:00

abstract：:Malaria remains one of the greatest impediments to development in many tropical regions of the world. Understanding host immune responses to malaria parasites is crucial for the effective design and implementation of new vaccines and drugs. Recent research has seen the identification of the first pattern recognition r...

journal_title：Current opinion in immunology

authors： Engwerda CR,Good MF

更新日期：2005-08-01 00:00:00

abstract：:Most viral vaccines provide protection from infection through the generation of neutralizing antibodies (nAbs). The repertoire of B cells responding to immunization is the starting material from which nAbs eventually arise. Immunization strategies are increasingly targeting precise B cell specificities to mimic nAbs g...

journal_title：Current opinion in immunology

authors： Havenar-Daughton C,Abbott RK,Schief WR,Crotty S

更新日期：2018-08-01 00:00:00

abstract：:Islets of Langerhans of all species harbor a small number of resident macrophages. These macrophages are found since birth, do not exchange with blood monocytes, and are maintained by a low level of replication. Under steady state conditions, the islet macrophages are in an activated state. Islet macrophages have an i...

journal_title：Current opinion in immunology

authors： Carrero JA,Ferris ST,Unanue ER

更新日期：2016-12-01 00:00:00

abstract：:The proteasome is the protein destroying machinery conserved in all eukaryotes and plays essential roles in various cellular processes. Apart from the conserved 'standard' proteasome, a special type of proteasome called 'immunoproteasome' exists in vertebrates for better presentation of antigenic peptides on MHC class...

journal_title：Current opinion in immunology

authors： Murata S,Takahama Y,Tanaka K

更新日期：2008-04-01 00:00:00

abstract：:Much has been learned recently about the structure and function of 55 kDa bactericidal/permeability-increasing protein (BPI), a member of a genomically conserved lipid-interactive protein family. Analysis of BPI fragments and the crystal structure of human BPI have established that BPI consists of two functionally dis...

journal_title：Current opinion in immunology

authors： Elsbach P,Weiss J

更新日期：1998-02-01 00:00:00

abstract：:The steep rise in the incidence and prevalence of food allergy (FA) in the last few decades have focused attention of environmental mechanisms which act to promote disease, chief among which is the microbiome. Recent studies have now established the presence of pathogenic dysbiosis in FA that could be precipitated by ...

journal_title：Current opinion in immunology

authors： Stephen-Victor E,Chatila TA

更新日期：2019-10-01 00:00:00

abstract：:Cells of the adaptive immune system (T and B cells) causing autoimmunity require activation signals that are normally provided by the innate immune system. Innate signaling receptors are obvious candidates for participation in the induction of autoimmunity, and the nature of these receptors suggests that microbes coul...

journal_title：Current opinion in immunology

authors： Chervonsky A

更新日期：2009-12-01 00:00:00

abstract：:Food allergy is now known to encompass a number of distinct clinical entities that follow the ingestion of specific food or food additives. Research continues to shed light on immediate reactions to foods and food protein-induced enterocolitis of newborns and infants. Adverse reactions to food additives remain an area...

journal_title：Current opinion in immunology

authors： Metcalfe DD

更新日期：1991-12-01 00:00:00

abstract：:Rheumatoid arthritis is often considered to be an autoimmune disease in which the abnormal immunological response is triggered by an infectious agent(s) but progress towards identifying such extrinsic factors has so far been unrevealing. In contrast, the genetic component of host susceptibility is slowly becoming clea...

journal_title：Current opinion in immunology

authors： Wordsworth P

更新日期：1992-12-01 00:00:00

abstract：:Recent advances in mass spectrometry technology have facilitated detailed examination of MHC-II immunopeptidomes, for example the repertoires of peptides bound to MHC-II molecules expressed in antigen presenting cells. These studies have deepened our view of MHC-II presentation. Other studies have broadened our view o...

journal_title：Current opinion in immunology

authors： Stern LJ,Santambrogio L

更新日期：2016-06-01 00:00:00

abstract：:Antigen-receptor engagement is a complex, highly orchestrated rearrangement of signaling molecules at, and adjacent to, the plasma membrane. Recent discoveries have shown that the plasma membrane itself is differentiated into microdomains of distinct lipid constituents and that the affiliation of lipid-modified protei...

journal_title：Current opinion in immunology

authors： Xavier R,Seed B

更新日期：1999-06-01 00:00:00

abstract：:The field of Type 1 diabetes research has been quick to embrace the era of translational medicine in the recent epoch. Building upon some 30 years of intense immunological research, the past decade has been marked by a series of clinical trials designed to evaluate the potential beneficial effects of a range of immune...

journal_title：Current opinion in immunology

authors： Roep BO,Peakman M

更新日期：2011-12-01 00:00:00

abstract：:A major problem in the analysis of vaccine candidates is the lack of any agreed upon surrogates of efficacy, which means that for diseases that depend on a strong T cell response (HIV, TB especially) the only option is to perform an efficacy trial, involving thousands of subjects, enormous costs, and years before the ...

journal_title：Current opinion in immunology

authors： Davis MM

更新日期：2020-08-01 00:00:00

abstract：:Cytokines have been presumed to play an important role during T-cell development, but until recently formal proof has been missing. Most cytokine-knockout mice show apparently normal intrathymic T-cell development. The exception to this is IL-7, as both IL-7 and IL-7R alpha knockout mice show abnormally low thymic cel...

journal_title：Current opinion in immunology

authors： Zlotnik A,Moore TA

更新日期：1995-04-01 00:00:00

abstract：:Dendritic cells (DC) are heterogenous, comprising several subpopulations of migratory and lymphoid-organ-resident types. Recent studies addressing the role of each subset in antigen presentation in vivo have revealed a complex division of labor within the DC network. In addition to CD8(+) DC, migratory lung or dermal ...

journal_title：Current opinion in immunology

authors： Segura E,Villadangos JA

更新日期：2009-02-01 00:00:00

abstract：:The adhesive phenotypes expressed by Plasmodium-falciparum-infected erythrocytes were previously thought simply to permit sequestration of parasites in the peripheral circulation. Recent work has illuminated how falciparum-infected erythrocytes may modulate the function of monocytes, macrophages and myeloid dendritic ...

journal_title：Current opinion in immunology

authors： Urban BC,Roberts DJ

更新日期：2002-08-01 00:00:00

abstract：:Rational selection of individual adjuvants can often be made on the basis of innate molecular interactions of the foreign molecules with pattern recognition receptors such as Toll-like receptors. For example, monophosphoryl lipid A, a family of endotoxic TLR4 agonist molecules from bacteria, has recently been formulat...

journal_title：Current opinion in immunology

authors： Alving CR,Peachman KK,Rao M,Reed SG

更新日期：2012-06-01 00:00:00

abstract：:Infectious diseases are the result of the exposure of susceptible hosts to pathogenic microbes. Genetic factors are important determinants of host susceptibility and efforts are being made to establish the molecular identity of such genetic susceptibility variants by genome-wide association studies. Results obtained t...

journal_title：Current opinion in immunology

authors： Abel L,Alcaïs A,Schurr E

更新日期：2014-10-01 00:00:00

abstract：:A subfamily of serine proteases is uniquely expressed by cytotoxic natural killer lymphocytes and T cells. Protease cleavage of different natural substrates is now implicated in the cytotoxic mechanisms of target cell membrane pore formation, DNA fragmentation and cytostasis. ...

journal_title：Current opinion in immunology

authors： Hudig D,Ewoldt GR,Woodard SL

更新日期：1993-02-01 00:00:00

abstract：:Theileria parasites infect and transform cells of the ruminant immune system. Continuous proliferation and survival of Theileria-transformed cells involves the well-orchestrated activation of several host-cell signalling pathways. Constitutive NF-kappa B (nuclear factor kappa B) activation is accomplished by recruitin...

journal_title：Current opinion in immunology

authors： Dobbelaere DA,Küenzi P

更新日期：2004-08-01 00:00:00

abstract：:Phosphoinositide 3-kinase (PI3K) defines a family of lipid kinases that direct a wide range of cellular processes and cell fate decisions. Since its discovery, and that of its enzymatic antagonist PTEN, much of the focus on PI3K has been on its oncogenic potential. In recent years, studies on PI3K signaling in B lymph...

journal_title：Current opinion in immunology

authors： Baracho GV,Miletic AV,Omori SA,Cato MH,Rickert RC

更新日期：2011-04-01 00:00:00

abstract：:Recent findings have significantly advanced our understanding of the mechanism by which the potent immunosuppressive drug rapamycin inhibits cytokine-dependent lymphocyte proliferation. The protein targeted by the immunophilin-rapamycin complex is a member of a newly defined family of phosphoinositide-3-kinase-related...

journal_title：Current opinion in immunology

authors： Abraham RT

更新日期：1998-06-01 00:00:00

abstract：:Insects are particularly resistant to microorganisms. Their host-defense system relies on several innate reactions: upon injury, the immediate onset of two proteolytic cascades leading to localized blood clotting and to melanization, the latter process involving production of cytotoxic molecules (namely reactive oxyge...

journal_title：Current opinion in immunology

authors： Hoffmann JA

更新日期：1995-02-01 00:00:00