Tuberculosis vaccines - perspectives from the NIH/NIAID Mycobacteria vaccine testing program.

Abstract:

:The development of novel vaccine candidates against infections with Mycobacterium tuberculosis has highlighted our limited understanding of immune mechanisms required to kill M. tuberculosis. The induction of a Th1 immunity is vital, but new studies are required to identify other mechanisms that may be necessary. Novel vaccines formulations that invoke effector cells such as innate lymphoid cells may provide an environment that promote effector mechanisms including T cell and B cell mediated immunity. Identifying pathways associated with killing this highly successful infectious agent has become critical to achieving the goal of reducing the global tuberculosis burden.

journal_name

Curr Opin Immunol

authors

Izzo AA

doi

10.1016/j.coi.2017.07.008

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

78-84

eissn

0952-7915

issn

1879-0372

pii

S0952-7915(16)30099-1

journal_volume

47

pub_type

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