Abstract:
:The immune system is a delicately balanced network of interacting cells. In recent years, the concept of immune regulation/suppression has been firmly established, and both natural and induced regulatory cells play vital roles in protection from autoimmune disease. Recent work has revealed the diverse nature of regulatory CD4+ T (Treg) cells and the molecules involved in their function. Innate and adaptive responses to infection are able to override the suppressive properties of such regulatory cells, whereas several reports point to deficiencies in regulatory cell function in autoimmune disease. Protocols have been developed that allow the expansion of Treg cells in vitro and their antigen-specific induction in vivo. A full understanding of Treg differentiation and function will facilitate the development of improved strategies for prevention and treatment of autoimmune diseases.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Wraith DC,Nicolson KS,Whitley NTdoi
10.1016/j.coi.2004.09.015subject
Has Abstractpub_date
2004-12-01 00:00:00pages
695-701issue
6eissn
0952-7915issn
1879-0372pii
S0952-7915(04)00160-8journal_volume
16pub_type
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