Abstract:
:The diverse αβ T cell receptor (TCR) repertoire exhibits versatility in its ability to generate antigen (Ag) receptors capable of interacting with polymorphic Major Histocompatibility Complex (MHC) molecules and monomorphic MHC-I like molecules, including the CD1 and MR1 families. Collectively, these evolutionarily related Ag-presenting molecules present peptides, lipids and vitamin B metabolites for T cell surveillance. Interestingly, whilst common TCR gene usage can underpin recognition of these distinct classes of Ags, it is unclear whether the 'rules' that govern αβTCR-Ag MHC interactions are shared. We highlight recent observations in the context of TCR biases towards MHC and MHC-I like molecules.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Eckle SB,Turner SJ,Rossjohn J,McCluskey Jdoi
10.1016/j.coi.2013.07.010subject
Has Abstractpub_date
2013-10-01 00:00:00pages
653-9issue
5eissn
0952-7915issn
1879-0372pii
S0952-7915(13)00125-8journal_volume
25pub_type
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