Abstract：
:Human papillomaviruses (HPVs) have been associated with benign and malignant epithelial proliferations in either skin or mucosa. Two HPV oncogenic proteins, E6 and E7, are important in the induction and maintenance of cellular transformation and are co-expressed in the majority of HPV-containing carcinomas. Therefore, vaccines targeted to these proteins may provide an opportunity to prevent and treat HPV-associated malignancies. The encouraging results from recent experimental vaccination systems in animal models suggest that continued exploration in these systems might lead to trials on human subjects and might allow us to prevent HPV infection or control its potentially life-threatening consequences.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Wu TCdoi
10.1016/0952-7915(94)90079-5subject
Has Abstractpub_date
1994-10-01 00:00:00pages
746-54issue
5eissn
0952-7915issn
1879-0372pii
0952-7915(94)90079-5journal_volume
6pub_type
杂志文章,评审abstract：:During the past couple of years there has been significant progress in our understanding of the development of different lineages of T cells within the thymus. Pathways, subpopulations and cellular dynamics are all becoming clearer. Signal transduction through primary and accessory receptors is also beginning to be un...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(91)90051-2
更新日期：1991-04-01 00:00:00
abstract：:Natural killer T (NKT) cells are a distinct lymphocyte lineage that regulates immune responses. During their development in the thymus, immature uncommitted double-positive CD4+CD8+ thymocytes that rearrange the semi-invariant T-cell receptor found on mature NKT cells are positively selected by the non-classical MHC c...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2005.01.002
更新日期：2005-04-01 00:00:00
abstract：:Dicer is a multifunctional protein that is essential across species for the generation of microRNAs, a function that is highly conserved across the plant and animal kingdoms. Intriguingly, Dicer exhibits antiviral functions in lower organisms including Drosophila melanogaster and Caenorhabditis elegans. Antiviral acti...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2013.10.015
更新日期：2014-02-01 00:00:00
abstract：:Lymphoid tissue inducer (LTi) cells are programmed by the mammalian fetus to induce the development of lymph nodes and Peyer's patches. LTi cells share a pro-inflammatory profile with Th17 cells, as well as their requirement for the transcription factor RORγt. We discuss here the latest data on the fetal and post-nata...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2012.02.003
更新日期：2012-04-01 00:00:00
abstract：:Innate and adaptive immune responses target pathogenic fungi and provide defense against fungal infections. Recent studies demonstrate that specific host receptors recognize ligands that are unique to fungi and activate signaling cascades that lead to phagocytosis of fungi, generation of pro-inflammatory mediators, fo...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2006.05.003
更新日期：2006-08-01 00:00:00
abstract：:Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is respon...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(97)80166-5
更新日期：1997-02-01 00:00:00
abstract：:Initially, direct oncolysis was thought to be the sole mechanism through which oncolytic viruses (OVs) exert their anti-tumor effect, and the immune system was perceived as the major obstacle in oncolytic virotherapy. Over the last decade, there has been a lot of debate on whether the immune system is a friend or foe ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2018.03.008
更新日期：2018-04-01 00:00:00
abstract：:Germinal centers (GCs) are well known for their important role in shaping the secondary B cell repertoire to generate antibodies capable of binding with high-affinity and specificity to foreign antigens. Somatic hypermutation of the Ig variable region genes in GC B cells represents a highly efficient mechanism for gen...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2019.11.001
更新日期：2020-04-01 00:00:00
abstract：:A strong skeleton relies on adaptation to varying physical demands and on maintenance of the bone tissue in order to avoid accumulation of micro-damage. In bone, the purinergic P2X7 ion channel receptor is expressed on both cells of the stromal lineage such as the bone forming osteoblasts and the mechano-sensing osteo...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2018.03.016
更新日期：2018-06-01 00:00:00
abstract：:The yeast two-hybrid technique provides a general approach for cloning cDNAs merely by exploiting the ability of their encoded proteins to bind to a protein of interest. The technique therefore offered a useful access to the analysis of the mechanisms of cell death at the initial stage of their study, when only a few ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(98)80240-9
更新日期：1998-04-01 00:00:00
abstract：:Vaccines prophylactic against infection with human papillomavirus (HPV) are based on alum adjuvanted virus-like particles. Two such vaccines have recently been shown to prevent persistent HPV infection and associated cervical cancer precursor lesions. The genotype-specific neutralising antibody directed at conformatio...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2007.01.004
更新日期：2007-04-01 00:00:00
abstract：:While the role of PD-1 in inhibiting immunity during chronic infections is well established, its functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T cell responses during some acute infections and restrain responses by 'helpless' CD8 memory T cells. An emerging role for PD-1 in inn...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2010.03.007
更新日期：2010-06-01 00:00:00
abstract：:Antibody deficiencies are the most prevalent forms of primary immunodeficiencies (PIDs). Several disease-causing mutations have been identified to date, but still, the genetic background of most patients remains elusive. During the last 2 years, next generation sequencing has revealed the genetic basis for a number of...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2013.06.003
更新日期：2013-10-01 00:00:00
abstract：:Many humanized antibodies and fusion proteins targeting T-cell co-stimulatory molecules are now in late-stage clinical development (phase II, phase III) or have recently completed phase III clinical trials. Both Amevive, an LFA-3-Ig fusion protein targeting CD2, and Xanelim, a humanized anti-CD11a antibody, have shown...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(01)00279-5
更新日期：2001-12-01 00:00:00
abstract：:Over the past year, we have witnessed the discovery of further virus immuno-evasins--proteins that alter the host immune response. Although many of these factors have been described over the past decade, the structural basis underlying their biology has lagged behind. Structural data have now been obtained for several...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(00)00239-9
更新日期：2001-08-01 00:00:00
abstract：:A diverse B cell repertoire is essential for an effective immune response. Not only to provide a variety of antibodies to recognise the multiplicity of likely pathogen challenge, but also because B cells are important regulators of the immune response. In addition to their excellent capabilities as antigen presenting ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2010.04.009
更新日期：2010-08-01 00:00:00
abstract：:V(D)J recombination in B and T cells is required for the generation of receptors with a broad spectrum of specificity to foreign antigen. A total number of three immunoglobulin (Ig) and four T cell receptor (Tcr) loci can be targeted by the recombinase enzyme (RAG1/2) in a defined series of recombination events, which...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2012.01.003
更新日期：2012-04-01 00:00:00
abstract：:Chronic non-communicable diseases (NCDs) are increasingly recognized as the major cause of morbidity and mortality worldwide. Effective, affordable and broadly accessible medicines for their treatment are much sought after. Therapeutic B-cell vaccines aim at inducing neutralizing auto-reactive antibodies against impor...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2010.02.009
更新日期：2010-06-01 00:00:00
abstract：:The innate immune system is comprised of a sophisticated network of recognition and effector molecules that act together to protect the host in the first minutes or hours of exposure to an infectious challenge. The mannose-binding lectin (MBL) is an evolutionary conserved circulating host defense protein that acts as ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2005.11.014
更新日期：2006-02-01 00:00:00
abstract：:The past few years have seen significant growth in the number of known chemokines. Along with expansion in this field has come an appreciation of a role for chemokines beyond the chemotaxis of leukocytes. In particular, it appears that these molecules may represent major products of activated lymphocytes and that, in ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(96)80123-3
更新日期：1996-06-01 00:00:00
abstract：:Conceptually, a universal influenza vaccine should elicit broadly protective antibody responses targeting highly conserved epitope(s) shared by various virus strains. Strategically directing antibody immunity to the conserved hemagglutinin stalk has recently emerged as a promising approach that is substantiated by the...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2018.03.020
更新日期：2018-08-01 00:00:00
abstract：:Hepatitis B virus (HBV) infection is a global health problem. There are >350 million of people chronically infected with this virus worldwide. Hepatitis B vaccines are effective in preventing the infection. Humoral immunity is the key factor in conferring the protection. Hepatitis B surface antibody titers of ≥10mIU/m...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2010.12.013
更新日期：2011-04-01 00:00:00
abstract：:Much has been learned recently about the structure and function of 55 kDa bactericidal/permeability-increasing protein (BPI), a member of a genomically conserved lipid-interactive protein family. Analysis of BPI fragments and the crystal structure of human BPI have established that BPI consists of two functionally dis...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(98)80030-7
更新日期：1998-02-01 00:00:00
abstract：:Type I diabetes has resisted direct genetic analysis in humans but two excellent models of disease in rodents provide a more readily manipulated alternative for study. These rodent models are being used successfully to localize the genes that are involved in disease pathogenesis in preparation for positional cloning. ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(98)80092-7
更新日期：1998-12-01 00:00:00
abstract：:Antigen-receptor engagement is a complex, highly orchestrated rearrangement of signaling molecules at, and adjacent to, the plasma membrane. Recent discoveries have shown that the plasma membrane itself is differentiated into microdomains of distinct lipid constituents and that the affiliation of lipid-modified protei...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(99)80043-0
更新日期：1999-06-01 00:00:00
abstract：:The discovery of novel immune receptors has led to a recent renaissance of research into the innate immune system, following decades of intense research of the adaptive immune system. Of particular interest has been the discovery of the natural killer (NK) cell receptors which, depending on type, interact with classic...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2007.08.002
更新日期：2007-10-01 00:00:00
abstract：:Recent studies have increased our understanding of the nature of autoimmune recognition and of the identity of autoantigens, at least in model systems. Knowledge of the autoantigens and the process of recognition is suggesting new therapies for autoimmune disease. ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(91)90071-8
更新日期：1991-02-01 00:00:00
abstract：:The past year has seen the discovery of new isolates which do not readily fit into the established categories HIV-1, HIV-2 and SIV, as well as the availability of new assays including the use of the polymerase chain reaction. New combination enzyme-linked immunosorbent assays can detect viruses from two or more groups...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(91)90018-v
更新日期：1991-08-01 00:00:00
abstract：:Peanuts are a frequent cause of food allergy and the most common cause of fatal food-induced anaphylaxis in the U.S. Advances during the past two years have promoted our understanding of peanut allergens and peanut allergy prevalence, etiology, diagnosis, and therapy. The advances highlighted in this review include ev...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2010.10.005
更新日期：2010-12-01 00:00:00
abstract：:Viruses that establish persistent infections in their host, such as herpesviruses, adenoviruses or HIV, express proteins designed to pre-empt or evade recognition and elimination by MHC class I restricted CD8+ T lymphocytes. Notable discoveries during the annual period of review have demonstrated that, in principle, e...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(97)80097-0
更新日期：1997-08-01 00:00:00
