Abstract：
:Much has been learned recently about the structure and function of 55 kDa bactericidal/permeability-increasing protein (BPI), a member of a genomically conserved lipid-interactive protein family. Analysis of BPI fragments and the crystal structure of human BPI have established that BPI consists of two functionally distinct domains: a potently antibacterial and anti-endotoxin amino-terminal domain (approximately 20 kDa) and a carboxy-terminal portion that imparts opsonic activity to BPI. A recombinant amino-terminal fragment (rBPI21) protects animals against the effects of Gram-negative bacteria and endotoxin. In man, rBPI21 is nontoxic and non-immunogenic and is in Phase II/III clinical trials with apparent therapeutic benefit.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Elsbach P,Weiss Jdoi
10.1016/s0952-7915(98)80030-7subject
Has Abstractpub_date
1998-02-01 00:00:00pages
45-9issue
1eissn
0952-7915issn
1879-0372pii
S0952-7915(98)80030-7journal_volume
10pub_type
杂志文章,评审abstract：:Antibody deficiencies are the most prevalent forms of primary immunodeficiencies (PIDs). Several disease-causing mutations have been identified to date, but still, the genetic background of most patients remains elusive. During the last 2 years, next generation sequencing has revealed the genetic basis for a number of...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2013.06.003
更新日期：2013-10-01 00:00:00
abstract：:Phosphoinositide 3-kinase (PI3K) defines a family of lipid kinases that direct a wide range of cellular processes and cell fate decisions. Since its discovery, and that of its enzymatic antagonist PTEN, much of the focus on PI3K has been on its oncogenic potential. In recent years, studies on PI3K signaling in B lymph...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2011.01.001
更新日期：2011-04-01 00:00:00
abstract：:Phosphoinositide 3-kinase (PI3K) activation is essential for lymphocyte proliferation driven by receptors for antigen, costimulatory ligands and cytokines. The lipid products of PI3K contribute to the assembly of membrane-associated signaling complexes by promoting recruitment of selected proteins from the cytoplasm. ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2004.03.014
更新日期：2004-06-01 00:00:00
abstract：:Recent research in systemic lupus erythematosus and animal models of lupus has provided new insight into the pathogenesis of this complex autoimmune disease. Progress has been made towards understanding the genetic contributions to disease susceptibility and induction, as well as towards elucidation of the lymphocyte ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(92)90054-i
更新日期：1992-12-01 00:00:00
abstract：:Mucosal vaccines may be used both to prevent mucosal infections through the activation of antimicrobial immunity and to treat systemic inflammatory diseases through the induction of antigen-specific mucosal tolerance. New, efficient mucosal adjuvants for human use have been designed based on, amongst others, bacterial...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(02)00384-9
更新日期：2002-10-01 00:00:00
abstract：:The sensing of nucleic acids by pattern recognition receptors is a central feature of innate immunity and is mediated by two types of receptors, Toll-like receptors and cytosolic receptors. Indeed, DNA, be it pathogen-derived or self-derived, can potently trigger the innate immune system; and much attention has been f...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2009.01.005
更新日期：2009-02-01 00:00:00
abstract：:The past year has seen significant advances in our understanding of critical roles of negative immunoregulatory signals delivered through the B7-CD28 superfamily in regulating T cell activation and tolerance. Structural data on CTLA-4 have provided novel insights into the inhibitory functions of CTLA-4. Initial charac...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(02)00341-2
更新日期：2002-06-01 00:00:00
abstract：:Many of the pathogens that cause human infectious diseases do not infect rodents or other mammalian species. Small animal models that allow studies of the pathogenesis of these agents and evaluation of drug efficacy are critical for identifying ways to prevent and treat human infectious diseases. Immunodeficient mice ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2013.05.012
更新日期：2013-08-01 00:00:00
abstract：:The NLR (nucleotide-binding domain leucine-rich repeat containing) family of intracellular sensors is a crucial component of the innate immune system. A number of NLR family members can form multiprotein complexes, called inflammasomes, and are capable of activating the cysteine protease caspase-1 in response to a wid...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2009.01.006
更新日期：2009-02-01 00:00:00
abstract：:Innate immunity, our inborn immediate defence mechanism, was thought for a long time to be non-specific and, consequently, research into innate mechanisms often took second place to research into adaptive immunity. In recent decades, however, the spotlight has shone on groundbreaking advances into mechanisms of innate...
journal_title：Current opinion in immunology
pub_type： 杂志文章
doi：10.1016/j.coi.2003.09.020
更新日期：2003-12-01 00:00:00
abstract：:Although autoantigen-induced negative selection plays an important role in shaping the mature B-cell repertoire, studies in recent years have suggested that differentiation into any of the three mature B-cell subsets (marginal zone B cells, follicular B cells and B-1 B cells) is not a passive product of autoreactive B...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2004.01.006
更新日期：2004-04-01 00:00:00
abstract：:The usefulness of molecular diagnosis is now well established for genetically determined recurrent fevers. In familial Mediterranean fever, the severity of the disease and the risk of renal amyloidosis are correlated with mutations in MEFV, and the serum amyloid-associated protein (SAA)1 alpha/alpha allele is a modify...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(00)00255-7
更新日期：2001-10-01 00:00:00
abstract：:Sensing of RNA virus infection by the RIG-I-like receptors (RLRs) engages a complex signaling cascade that utilizes the mitochondrial antiviral signaling (MAVS) adapter protein to orchestrate the innate host response to pathogen, ultimately leading to the induction of antiviral and inflammatory responses mediated by t...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2011.08.001
更新日期：2011-10-01 00:00:00
abstract：:Invariant natural killer T cells (iNKT cells) express a restricted T cell antigen receptor (TCR) repertoire and they respond rapidly to glycolipid antigens presented by CD1d. These glycolipid antigens have hexose sugars in alpha-linkage to two types of lipids that can bind to CD1d. Recent work has shown that the respo...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2009.07.002
更新日期：2009-08-01 00:00:00
abstract：:The presentation of antigenic peptides by MHC class I molecules plays a vital role in generating T cell responses against infection and cancer. Over the last two decades the central role of tapasin as a peptide editor that influences the loading and optimisation of peptides onto MHC class I molecules has been extensiv...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2017.04.008
更新日期：2017-06-01 00:00:00
abstract：:The Notch family of evolutionarily conserved proteins regulates a broad spectrum of cell-fate decisions and differentiation processes during fetal and post-natal development. The best characterized role of Notch signaling during mammalian hematopoiesis and lymphopoiesis is the essential function of the Notch1 receptor...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2004.01.002
更新日期：2004-04-01 00:00:00
abstract：:The proteasome is the protein destroying machinery conserved in all eukaryotes and plays essential roles in various cellular processes. Apart from the conserved 'standard' proteasome, a special type of proteasome called 'immunoproteasome' exists in vertebrates for better presentation of antigenic peptides on MHC class...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2008.03.002
更新日期：2008-04-01 00:00:00
abstract：:The efficient induction of interferons alpha and beta (IFN-alpha/beta) in virus-infected cells is central to the antiviral response of a host and is regulated mainly at the level of gene transcription. Once produced, IFN-alpha/beta transmit signals to the cell interior via a specific receptor complex to induce an anti...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(01)00305-3
更新日期：2002-02-01 00:00:00
abstract：:Vaccines prophylactic against infection with human papillomavirus (HPV) are based on alum adjuvanted virus-like particles. Two such vaccines have recently been shown to prevent persistent HPV infection and associated cervical cancer precursor lesions. The genotype-specific neutralising antibody directed at conformatio...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2007.01.004
更新日期：2007-04-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2012.10.004
更新日期：2012-12-01 00:00:00
abstract：:B cells that fail to pass a developmental checkpoint, either as immature or mature B cells, can be rescued by creating a new B cell antigen receptor through nested secondary immunoglobulin gene rearrangements, a process termed receptor editing. Tolerance-mediated receptor editing occurs in self-reactive immature bone ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(98)80250-1
更新日期：1998-04-01 00:00:00
abstract：:Atopic dermatitis is a chronic inflammatory skin disease associated with elevated serum IgE levels and sensitization to a variety of inhalant, food and microbial allergens. Controlled challenges have provided substantial evidence that allergens can trigger acute IgE-mediated mast-cell dependent exacerbations of eczema...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(93)90112-6
更新日期：1993-12-01 00:00:00
abstract：:Rapid progress in the discovery of members of the tumor necrosis factor receptor/ligand superfamilies has been made, mainly with the help of massive DNA sequencing and bioinformatic studies. Biological studies of the new members have not only indicated overlapping roles with other members but also provided insights in...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(99)80054-5
更新日期：1999-06-01 00:00:00
abstract：:The development of novel vaccine candidates against infections with Mycobacterium tuberculosis has highlighted our limited understanding of immune mechanisms required to kill M. tuberculosis. The induction of a Th1 immunity is vital, but new studies are required to identify other mechanisms that may be necessary. Nove...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2017.07.008
更新日期：2017-08-01 00:00:00
abstract：:The adoptive transfer of T cells engineered to express artificial chimeric antigen receptors CARs) that target a tumor cell surface molecule has emerged as an exciting new approach for cancer immunotherapy. Clinical trials in patients with advanced B cell malignancies treated with CD19-specific CAR-modified T cells (C...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2015.01.002
更新日期：2015-04-01 00:00:00
abstract：:Recent studies of the regulation of antigen receptor rearrangement have revealed several completely new levels of control. Not only do antigen receptor loci undergo changes in histone modifications as they become accessible for recombination, but also the number of different histone modifications and the variation at ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2010.12.008
更新日期：2011-04-01 00:00:00
abstract：:Basophils are rare effector cells of the innate immune system. They are generally associated with type 2 immune responses that develop during helminth infections and allergic reactions. The role of basophils for initiation and execution of allergic immune responses is not well understood. Over the past few years new t...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2011.09.005
更新日期：2011-12-01 00:00:00
abstract：:Despite being unable to mount a bona fide recall antibody (Ab) response to secondary immunization, T cell-independent antigens (TI Ag) such as pneumococcal capsular polysaccharides (PS) can generate protective humoral immunity in adults. The concept of TI B cell memory after being iconoclastic for decades has now rece...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2011.03.004
更新日期：2011-06-01 00:00:00
abstract：:The treatment of autoimmune diseases using conventional chemical immunosuppressants has short-term effects, imposing the need for chronic treatment with its risks of over-immunosuppression. CD3-specific monoclonal antibodies can restore self-tolerance in a durable fashion after a single short-term treatment, as demons...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2005.09.011
更新日期：2005-12-01 00:00:00
abstract：:Herpes zoster is common in older and immune suppressed persons due to diminished VZV-specific cellular immunity. A recombinant herpes zoster vaccine (RZV) consisting of a single VZV glycoprotein and an adjuvant system stimulates robust and persistent VZV-specific antibody and CD4+ T cell responses in these high-risk p...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2019.02.009
更新日期：2019-08-01 00:00:00
