Receptor editing and commitment in B lymphocytes.

abstract：:Type I and type II interferons (IFNα/β and IFNγ) are cytokines that play indispensable roles in directing myeloid cell activity during inflammatory and immune responses. Each IFN type binds a distinct receptor (IFNAR or IFNGR) to transduce signals that reshape gene expression and function of myeloid and other cell typ...

journal_title：Current opinion in immunology

authors： Crisler WJ,Lenz LL

更新日期：2018-10-01 00:00:00

abstract：:The yeast two-hybrid technique provides a general approach for cloning cDNAs merely by exploiting the ability of their encoded proteins to bind to a protein of interest. The technique therefore offered a useful access to the analysis of the mechanisms of cell death at the initial stage of their study, when only a few ...

journal_title：Current opinion in immunology

authors： Wallach D,Boldin MP,Kovalenko AV,Malinin NL,Mett IL,Camonis JH

更新日期：1998-04-01 00:00:00

abstract：:The development of novel vaccine candidates against infections with Mycobacterium tuberculosis has highlighted our limited understanding of immune mechanisms required to kill M. tuberculosis. The induction of a Th1 immunity is vital, but new studies are required to identify other mechanisms that may be necessary. Nove...

journal_title：Current opinion in immunology

authors： Izzo AA

更新日期：2017-08-01 00:00:00

abstract：:The past few years have seen significant growth in the number of known chemokines. Along with expansion in this field has come an appreciation of a role for chemokines beyond the chemotaxis of leukocytes. In particular, it appears that these molecules may represent major products of activated lymphocytes and that, in ...

journal_title：Current opinion in immunology

authors： Hedrick JA,Zlotnik A

更新日期：1996-06-01 00:00:00

abstract：:Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and con...

journal_title：Current opinion in immunology

authors： Johnson RP,Desrosiers RC

更新日期：1998-08-01 00:00:00

abstract：:Animal models of inflammatory bowel disease (IBD) have been useful in the identification of those immune responses uniquely involved in IBD pathogenesis and in defining the important roles of environmental influences, such as normal luminal bacterial flora and the genetic composition of the host, in modifying IBD-asso...

journal_title：Current opinion in immunology

authors： Blumberg RS,Saubermann LJ,Strober W

更新日期：1999-12-01 00:00:00

abstract：:While certain bacteria and respiratory viruses promote local inflammation and disease onset, a more diverse colonization of the different species in the (gut) microbiome may be linked to more regulatory responses and protection against asthma and allergies. These processes are also influenced in part by food intake, b...

journal_title：Current opinion in immunology

authors： Smits HH,van der Vlugt LE,von Mutius E,Hiemstra PS

更新日期：2016-10-01 00:00:00

abstract：:Regulatory T (Treg) cells suppress effector T (Teff) cells and prevent immune-mediated rejection of cancer. Much less appreciated are mechanisms by which Teff cells antagonize Treg cells. Herein, we consider how complex reciprocal interactions between Teff and Treg cells shape their population dynamics within tumors. ...

journal_title：Current opinion in immunology

authors： Roychoudhuri R,Eil RL,Restifo NP

更新日期：2015-04-01 00:00:00

abstract：:Since the establishment of methods to isolate genes encoding cytotoxic T lymphocyte defined tumor antigens, several antigens have been identified and characterized for suitability as target antigens for immunotherapy. The development of innovative strategies to generate T cells targeting these antigens and lessons lea...

journal_title：Current opinion in immunology

authors： Yee C,Riddell SR,Greenberg PD

更新日期：1997-10-01 00:00:00

abstract：:Monoclonal antibodies specific for defined peptide-MHC complexes are now being used to physically detect T-cell receptor ligands. These reagents have resulted in the identification of the cells that present antigen in lymphoid and non-lymphoid tissues after various forms of antigen administration. In addition, recent ...

journal_title：Current opinion in immunology

authors： Germain RN,Jenkins MK

更新日期：2004-02-01 00:00:00

abstract：:T cell responses are regulated by integrating positive and negative signals from costimulatory and inhibitory receptors. While the function of specific T cell costimulatory molecules during infections has been appreciated for some time, recent observations have now revealed a crucial role for inhibitory receptors in r...

journal_title：Current opinion in immunology

authors： Crawford A,Wherry EJ

更新日期：2009-04-01 00:00:00

abstract：:Our understanding of the X-linked lymphoproliferative syndrome (XLP) has advanced significantly in the past two years. The gene that is aberrant in the condition - SH2D1A/SAP, which encodes SAP (signaling lymphocytic activation molecule [SLAM]-associated protein) - was cloned, the crystal structure of its product was ...

journal_title：Current opinion in immunology

authors： Howie D,Sayos J,Terhorst C,Morra M

更新日期：2000-08-01 00:00:00

abstract：:V(D)J recombination not only comprises the molecular mechanism that insures diversity of the immune system but also constitutes a critical checkpoint in the developmental program of B and T lymphocytes. The analysis of human patients with severe combined immune deficiency (SCID) has enabled (and will enable in the fut...

journal_title：Current opinion in immunology

authors： de Villartay JP,Poinsignon C,de Chasseval R,Buck D,Le Guyader G,Villey I

更新日期：2003-10-01 00:00:00

abstract：:Fundamental advances in the fields of molecular biology and immunology have facilitated investigation of the autoimmune blistering disorders. Recently, the use of human autoantibodies has helped to identify biologically important adhesion molecules of the skin, and the pathogenic mechanisms involved in bullous skin di...

journal_title：Current opinion in immunology

authors： Nousari HC,Anhalt GJ

更新日期：1995-12-01 00:00:00

abstract：:The adoptive transfer of T cells isolated or engineered to have specificity for diseased cells represents an ideal approach for the targeted therapy of human viral and malignant diseases. The therapeutic potential of adoptive T cell therapy for infections and cancer was demonstrated in rodent models long ago, but the ...

journal_title：Current opinion in immunology

authors： Berger C,Turtle CJ,Jensen MC,Riddell SR

更新日期：2009-04-01 00:00:00

abstract：:Zika virus (ZIKV) is the most recent mosquito-transmitted virus to cause a global health crisis following its entrance into a naïve population in the Western Hemisphere. Once the ZIKV outbreak began investigators rapidly established small and large animal models of pathogenesis, developed a number candidate vaccines u...

journal_title：Current opinion in immunology

authors： Richner JM,Diamond MS

更新日期：2018-08-01 00:00:00

abstract：:The steep rise in the incidence and prevalence of food allergy (FA) in the last few decades have focused attention of environmental mechanisms which act to promote disease, chief among which is the microbiome. Recent studies have now established the presence of pathogenic dysbiosis in FA that could be precipitated by ...

journal_title：Current opinion in immunology

authors： Stephen-Victor E,Chatila TA

更新日期：2019-10-01 00:00:00

abstract：:Lymphoid cell differentiation relies on precisely orchestrated gene activation and repression events. Gene targeting studies have demonstrated crucial roles for the transcription factors Ikaros and Aiolos in regulating multiple stages of B and T cell development. Recent experiments suggest that Ikaros and Aiolos set B...

journal_title：Current opinion in immunology

authors： Cortes M,Wong E,Koipally J,Georgopoulos K

更新日期：1999-04-01 00:00:00

abstract：:While the role of PD-1 in inhibiting immunity during chronic infections is well established, its functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T cell responses during some acute infections and restrain responses by 'helpless' CD8 memory T cells. An emerging role for PD-1 in inn...

journal_title：Current opinion in immunology

authors： Brown KE,Freeman GJ,Wherry EJ,Sharpe AH

更新日期：2010-06-01 00:00:00

abstract：:The eosinophil is regarded as a key mediator of the pathology and abnormal physiology of bronchial asthma. Current investigations are directed at understanding how eosinophils are attracted into the respiratory tract and how they bring about the abnormalities characteristic of this disease. ...

journal_title：Current opinion in immunology

authors： Seminario MC,Gleich GJ

更新日期：1994-12-01 00:00:00

abstract：:Type I diabetes has resisted direct genetic analysis in humans but two excellent models of disease in rodents provide a more readily manipulated alternative for study. These rodent models are being used successfully to localize the genes that are involved in disease pathogenesis in preparation for positional cloning. ...

journal_title：Current opinion in immunology

authors： McDuffie M

更新日期：1998-12-01 00:00:00

abstract：:Many of the pathogens that cause human infectious diseases do not infect rodents or other mammalian species. Small animal models that allow studies of the pathogenesis of these agents and evaluation of drug efficacy are critical for identifying ways to prevent and treat human infectious diseases. Immunodeficient mice ...

journal_title：Current opinion in immunology

authors： Brehm MA,Jouvet N,Greiner DL,Shultz LD

更新日期：2013-08-01 00:00:00

abstract：:Defining the immunological goals for respiratory syncytial virus (RSV) vaccination requires understanding of RSV biology and tropism, mechanisms of cell-to-cell spread and immunity, epidemiology, and transmission dynamics. The immunological goals for a particular vaccine would be product-specific based on antigen sele...

journal_title：Current opinion in immunology

authors： Graham BS

更新日期：2019-08-01 00:00:00

abstract：:The formerly distinct fields of lymphocyte signal transduction and cytoskeletal remodeling have recently become linked, as proteins involved in transducing signals downstream of lymphocyte antigen receptors have also been implicated in actin cytoskeleton remodeling, microtubule dynamics and regulation of cell polarity...

journal_title：Current opinion in immunology

authors： Miletic AV,Swat M,Fujikawa K,Swat W

更新日期：2003-06-01 00:00:00

abstract：:Perforin defects have been identified in humans with familial hematophagocytic lymphohistiocytosis. The pathology of these patients has dramatically illustrated an under-appreciated role for perforin in the regulation of T-cell responses in vivo, and experimental studies are shedding light on the mechanisms involved. ...

journal_title：Current opinion in immunology

authors： Catalfamo M,Henkart PA

更新日期：2003-10-01 00:00:00

abstract：:Antiviral T-cell responses between individuals that have similar major histocompatibility complex molecules share similarities in epitope hierarchies and T-cell receptor variable gene usage (public specificities), yet the T-cell receptor amino acid sequences differ between individuals (private specificities). The sign...

journal_title：Current opinion in immunology

authors： Welsh RM

更新日期：2006-06-01 00:00:00

abstract：:Protective and pathogenic immune responses were initially thought to be determined by the differentiation of naïve T cells into Th1 and Th2 effector subsets and the immunosuppressive activity of thymic-derived regulatory T cells. It is now clear that naïve T cells can also differentiate into 'induced' regulatory T cel...

journal_title：Current opinion in immunology

authors： Sundrud MS,Rao A

更新日期：2007-06-01 00:00:00

abstract：:A subfamily of serine proteases is uniquely expressed by cytotoxic natural killer lymphocytes and T cells. Protease cleavage of different natural substrates is now implicated in the cytotoxic mechanisms of target cell membrane pore formation, DNA fragmentation and cytostasis. ...

journal_title：Current opinion in immunology

authors： Hudig D,Ewoldt GR,Woodard SL

更新日期：1993-02-01 00:00:00

abstract：:The treatment of autoimmune diseases using conventional chemical immunosuppressants has short-term effects, imposing the need for chronic treatment with its risks of over-immunosuppression. CD3-specific monoclonal antibodies can restore self-tolerance in a durable fashion after a single short-term treatment, as demons...

journal_title：Current opinion in immunology

authors： Chatenoud L

更新日期：2005-12-01 00:00:00

abstract：:Infectious diseases are the result of the exposure of susceptible hosts to pathogenic microbes. Genetic factors are important determinants of host susceptibility and efforts are being made to establish the molecular identity of such genetic susceptibility variants by genome-wide association studies. Results obtained t...

journal_title：Current opinion in immunology

authors： Abel L,Alcaïs A,Schurr E

更新日期：2014-10-01 00:00:00