Abstract:
:Zika virus (ZIKV) is the most recent mosquito-transmitted virus to cause a global health crisis following its entrance into a naïve population in the Western Hemisphere. Once the ZIKV outbreak began investigators rapidly established small and large animal models of pathogenesis, developed a number candidate vaccines using different platforms, and defined mechanisms of protection. In this review, we characterize the adaptive immune response elicited by ZIKV infections and vaccines, the status of ongoing clinical trials in humans, and discuss future challenges within the field.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Richner JM,Diamond MSdoi
10.1016/j.coi.2018.04.024subject
Has Abstractpub_date
2018-08-01 00:00:00pages
130-136eissn
0952-7915issn
1879-0372pii
S0952-7915(18)30049-9journal_volume
53pub_type
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2012.01.003
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2011.05.008
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(97)80166-5
更新日期:1997-02-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2010.09.001
更新日期:2010-12-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2019.08.004
更新日期:2019-12-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2004.03.014
更新日期:2004-06-01 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2012.07.010
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:2020-08-24 00:00:00
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2007.07.015
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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更新日期:2010-06-01 00:00:00
abstract::The major barrier to clinically successful pig-to-human xenotransplantation is antibody- and complement-dependent hyperacute rejection, known to be due to host anti-Galalpha(1,3)Gal antibodies. Strategies aimed at eliminating hyperacute rejection involve transgenic approaches to eliminate or reduce expression of Galal...
journal_title:Current opinion in immunology
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abstract::A diverse B cell repertoire is essential for an effective immune response. Not only to provide a variety of antibodies to recognise the multiplicity of likely pathogen challenge, but also because B cells are important regulators of the immune response. In addition to their excellent capabilities as antigen presenting ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2010.04.009
更新日期:2010-08-01 00:00:00
abstract::Innate immune perception is the first line of inducible defense against invading pathogens. Plants lack specialized circulating immune cells. Therefore, diverse cell types are able to recognize and respond to pathogens. Surface-localized and intracellular plant innate immune receptors are capable of recognizing divers...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2009.05.008
更新日期:2009-06-01 00:00:00
abstract::Clinical and experimental data now clearly indicate that chronic inflammation significantly contributes to cancer development. Emerging out of these studies is an appreciation that persistent humoral immune responses exacerbate recruitment and activation of innate immune cells in neoplastic microenvironments where the...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2007.01.001
更新日期:2007-04-01 00:00:00
abstract::Cells of the adaptive immune system (T and B cells) causing autoimmunity require activation signals that are normally provided by the innate immune system. Innate signaling receptors are obvious candidates for participation in the induction of autoimmunity, and the nature of these receptors suggests that microbes coul...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2009.08.003
更新日期:2009-12-01 00:00:00