Abstract：
:Macrophages specifically engulf apoptotic cells but not healthy cells. Phosphatidylserine (PtdSer) is localized at the inner leaflet of plasma membranes as a result of the action of flippases (ATP11A and 11C). When cells undergo apoptosis, caspase 3 cleaves and inactivates the flippases, while simultaneously cleaving XKR8 to activate its phospholipid scramblase activity. PtdSer is thus swiftly and irreversibly exposed to the cell surface as an 'eat me' signal. Tissue resident macrophages recognize the apoptotic cells using a PtdSer-receptor TIM4 and engulf them with TAM tyrosine-kinase receptors, and integrins. The PtdSer 'eat me' signal appears to override 'don't eat me' signals in most cases.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Nagata S,Segawa Kdoi
10.1016/j.coi.2020.07.007subject
Has Abstractpub_date
2020-08-24 00:00:00pages
1-8eissn
0952-7915issn
1879-0372pii
S0952-7915(20)30076-5journal_volume
68pub_type
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