Abstract:
:The induction and execution of a successful anti-pathogen immune response requires a consecutive series of cellular interactions that begin in lymphoid environments and later extend into the periphery. Much of our current knowledge of these events has been gained using ex vivo approaches that yield important static information but do not convey the dynamic nature of cellular behavior in vivo. The application of multiphoton-laser based microscopic analysis to the ongoing immune response has provided new insight into cellular interactions leading to T cell activation and the behavior of primed immune effectors. Here we discuss recent insights on anti-pathogen immune responses revealed using live imaging of both lymphoid and non-lymphoid tissues.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Mueller SN,Hickman HDdoi
10.1016/j.coi.2009.12.009subject
Has Abstractpub_date
2010-06-01 00:00:00pages
293-8issue
3eissn
0952-7915issn
1879-0372pii
S0952-7915(09)00232-5journal_volume
22pub_type
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