Abstract：
:MHC class II molecules (MHC-II) present antigenic fragments acquired in the endocytic route to the immune system for recognition and activation of CD4+ T cells. This ignites a series of immune responses. MHC-II strongly correlates to most autoimmune diseases. Understanding the biology of MHC-II is therefore expected to translate into novel means of autoimmunity control or immune response improvement. Although the basic cell biology of MHC-II antigen presentation is well understood, many novel aspects have been uncovered in recent years including means of antigen delivery, preparation for MHC-II loading, transport processes and vaccination strategies. We will discuss past, present and future of these insights into the biology of MHC-II.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
van den Hoorn T,Paul P,Jongsma ML,Neefjes Jdoi
10.1016/j.coi.2010.11.002subject
Has Abstractpub_date
2011-02-01 00:00:00pages
88-95issue
1eissn
0952-7915issn
1879-0372pii
S0952-7915(10)00177-9journal_volume
23pub_type
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